Open questions from cardiovascular studies FOURIER and ODYSSEY Outcomes


Authors: Ľubomíra Fábryová
Authors‘ workplace: Metabol KLINIK s. r. o., Bratislava
Published in: AtheroRev 2018; 3(3): 209-212
Category: clinical studies

Overview

In the years 2017 and 2018, the results of two large cardiovascular trials with inhi­bitors of pro-protein convertase subtilisin-kexin type 9 (PCSK9i) were published and confirmed the clinical benefits of their use in patients at high risk of developing athero­sclerosis-related cardiovascular disease (ASCVD). A summary analysis of FOURIER (Evolutionary Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk) study was published in NEJM [1]. In March 2018, during the ACC Congress in Orlando, the results of the ODYSSEY Outcomes Study (Assessment of Cardio­vascular Outcomes after an Acute Coronary Syndrome during Treatment with Alirocumab) were presented [2,3]. Although there are a number of open questions, the results of the trials confirm that further reduction of LDL-C leads to a reduction in the residual risk of ASCVD in high-risk patients and changes the hypothesis on LDL-C „the lower is better“ to reality and the need for everyday life. In clinical practice, however, we must always carefully consider adding PCSK9i. In secondary prevention in the first line intensive statin treatment with ezetimibe and lifestyle changes remains. PCSK9i is added to patients with LDL-C ≥ 1.8 mmol/l.

Key words:

ezetimibe , FOURIER , ODYSSEY Outcomes, PCSK9 inhibitors

Received: 3. 9. 2018

Accepted: 1. 10. 2018


Sources
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Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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