Diabetes mellitus and lipid metabolism
Authors:
Viliam Mojto
Authors‘ workplace:
III. interná klinika LF UK a UN Bratislava, Nemocnica akademika Ladislava Dérera
Published in:
AtheroRev 2016; 1(2): 69-73
Category:
Reviews
Overview
Diabetes mellitus is one of the most important risk factors for cardiovascular diseases. The risk is increased in presence of dyslipidemia. Diabetic dyslipidemia consists of elevation of triacylglycerols, low levels of HDL-cholesterol and elevation of LDL cholesterol. Defects in insulin action and hyperglycemia could lead to dyslipidemia. In the case of DM2, the obesity and insulin-resistant state lead to lipid abnormalities independently of hyperglycemia. In poorly controlled DM1 hypertriacylglyceridemia and reduced HDL-cholesterol commonly occur. Insulin controlled apoprotein production in the liver, regulation of lipoprotein lipase, actions of cholesteryl ester transfer protein and peripheral actions of insulin on adipose tissue and muscles are considered to be important mechanisms responsible for diabetic dyslipidemia. High intensive therapy of diabetic dyslipidemia will clearly reduce the risk of cardiovascular diseases in patients with DM.
Key words:
diabetes mellitus – ezetimib – fibrates – HDL-C – hypertriacylglycerolemia – small-dense LDL – statins
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Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adultsArticle was published in
Athero Review
2016 Issue 2
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