Anti-ischemic effect of ACE inhibitor perindopril confirmed by myocardial perfusion ima-ging (MPI) in a patient with coronary artery disease
Authors:
O. Lang 1,2,3; F. Málek 4
Authors‘ workplace:
Kardiologická klinika 3. LF UK, Praha 10
1; Oddělení nukleární medicíny PMCD s. r. o., Praha
2; Oddělení nukleární medicíny Oblastní nemocnice Příbram
3; Kardiologie, Nemocnice Na Homolce, Praha 5, ČR
4
Published in:
NuklMed 2024;13:10-11
Category:
Overview
A reversible defect on MPI study is closely associated with increased risk of cardiac events even if coronary angiography does not demonstrate a significant coronary artery stenosis. Recent studies have shown that anti-ischemic drugs can reduce or even normalize perfusion defects detected on MPI. ACE inhibitors have many properties that may be effective in the treatment of ischemic syndromes. They stabilize atherosclerotic plaques by inhibition of smooth muscle proliferation, by anti-oxidative properties and by inhibition of macrophages. They also prevent thrombotic complications by inhibition of platelet aggregation and facilitation of fibrinolysis.
Keywords:
ischemia – MPI – ACEI
Sources
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- Gould KL, Martucci JP, Goldberg DI, Hess MJ, Edens RP, Lafiti R et al: Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamol in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium. Circulation 1994;89:1530-1538
- Yusuf S, Lonn E: Anti-ischaemic effects of ACE inhibitors: review of current clinical evidence and ongoing clinical trials. Eur Heart J 1998;19:Supl J:J36-44
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Nuclear Medicine
2024 Issue 1
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