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Suicide − a serious health and social problem with the possibility of prevention


Authors: Martin Anders
Authors‘ workplace: Psychiatrická klinika 1. LF UK a VFN v Praze
Published in: Čas. Lék. čes. 2017; 156: 58-67
Category: Review Article

Overview

Suicide is a serious health and social problem whose incidence varies between genders, age groups, geographical distribution and with influence of socio-political structure of society. It has been identified many risk factors and this behavior has etiological heterogeneity.

There is no effective algorithm to predict suicidal activity in clinical practice, but increase the detection is associated with introducing the professional community and especially primary care physicians with clinical, psychological, sociological and biological factors whose can bring increasing of the recognition of vulnerable individuals and allow initiation of therapeutic interventions psychotherapy, psychopharmacology, neuromodulatory modalities or their combinations to achieve effective level of suicide prevention.

Keywords:
suicide, suicide attempt, suicidal ideation, suicide prevention, primary care, depressive disorder, anxiety disorder


Sources

1. WHO. Preventing suicide: a community engagement toolkit. Pilot version 1.0. World Health Organization, 2014. Dostupné na: www.who.int/mental_health/suicide-prevention/en/

2. Ahmedani BK, Simon GE, Stewart C et al. Health care contacts in the year before suicide death. J Gen Intern Med 2014; 29: 870–877.

3. Nock MK, Green JG, Hwang I et al. Prevalence, correlates, and treatment of lifetime suicidal behavior among adolescents: results from the National Comorbidity Survey Replication Adolescent Supplement. JAMA Psychiatry 2013; 70: 300–310.

4. Borges G, Nock MK, Haro Abad JM et al. Twelve-month prevalence of and risk factors for suicide attempts in the World Health Organization World Mental Health Surveys. J Clin Psychiatry 2010; 71: 1617–1628.

5. Nock MK, Borges G, Bromet EJ et al. Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br J Psychiatry 2008; 192: 98–105.

6. Weissman MM, Bland RC, Canino GJ et al. Prevalence of suicide ideation and suicide attempts in nine countries. Psychol Med 1999; 29: 9–17.

7. Johnston AK, Pirkis JE, Burgess PM. Suicidal thoughts and behaviours among Australian adults: findings from the 2007 National Survey of Mental Health and Wellbeing. Aust N Z J Psychiatry 2009; 43: 635–643.

8. Jeon HJ, Lee JY, Lee YM et al. Lifetime prevalence and correlates of suicidal ideation, plan, and single and multiple attempts in a Korean nationwide study. J Nerv Ment Dis 2010; 198: 643–646.

9. Carroll R, Metcalfe C, Gunnell D. Hospital presenting self-harm and risk of fatal and non-fatal repetition: systematic review and meta-analysis. PLoS One 2014; 9: e89944.

10. Brezo J, Paris J, Barker ED et al. Natural history of suicidal behaviors in a population-based sample of young adults. Psychol Med 2007; 37: 1563–1574.

11. Patton GC, Coffey C, Sawyer SM et al. Global patterns of mortality in young people: a systematic analysis of population health data. Lancet 2009; 374: 881–892.

12. Conwell Y, Van Orden K, Caine ED. Suicide in older adults. Psychiatr Clin North Am 2011; 34: 451–468.

13. Christodoulou C, Douzenis A, Papadopoulos FC et al. Suicide and seasonality. Acta Psychiatr Scand 2012; 125: 127–146.

14. Arltová M, Antovová M. Statistická analýza sebevražednosti v České republice z pohledu časových řad. Demografie 2016; 58: 29–48.

15. King M, Smith A, Gracey M. Indigenous health part 2: the underlying causes of the health gap. Lancet 2009; 374: 76–85.

16. Egeland JA, Sussex JN. Suicide and family loading for affective disorders. JAMA 1985; 254: 915–918.

17. Jollant F, Malafosse A, Docto R, Macdonald C. A pocket of very high suicide rates in a non-violent, egalitarian and cooperative population of South-East Asia. Psychol Med 2014; 17: 1–7.

18. Fountoulakis KN, Kawohl W, Theodorakis PN et al. Relationship of suicide rates to economic variables in Europe: 2000–2011. Br J Psychiatry 2014; 205: 486–496.

19. Reeves A, McKee M, Stuckler D. Economic suicides in the great recession in Europe and North America. Br J Psychiatry 2014; 205: 246–247.

20. Pirkis J, Nordentoft M. Media influences on suicide and attempted suicide. In: O’Connor RC, Platt S, Gordon J (eds.). International handbook of suicide prevention: research, policy and practice. John Wiley & Sons, Chichester, Malden, 2011: 531–544.

21. Brent DA, Bridge J, Johnson BA, Connolly J. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Arch Gen Psychiatry 1996; 53: 1145–1152.

22. Kim CD, Seguin M, Therrien N et al. Familial aggregation of suicidal behavior: a family study of male suicide completers from the general population. Am J Psychiatry 2005; 162: 1017–1019.

23. Tidemalm D, Runeson B, Waern M et al. Familial clustering of suicide risk: a total population study of 11.4 million individuals. Psychol Med 2011; 41: 2527–2534.

24. Brent DA, Melhem N. Familial transmission of suicidal behavior. Psychiatr Clin North Am 2008; 31: 157–177.

25. Schulsinger F, Kety SS, Rosenthal D, Wender PH. A family study of suicide. In: Schou M, Strömgren E (eds.). Origin, Prevention and Treatment of Affective Disorders. Academic Press, London, 1979: 277–287.

26. Statham DJ, Heath AC, Madden PA et al. Suicidal behaviour: an epidemiological and genetic study. Psychol Med 1998; 28: 839–855.

27. Fu Q, Heath AC, Bucholz KK et al. A twin study of genetic and environmental influences on suicidality in men. Psychol Med 2002; 32: 11–24.

28. Lieb R, Bronisch T, Höfler M et al. Maternal suicidality and risk of suicidality in offspring: findings from a community study. Am J Psychiatry 2005; 162: 1665–1671.

29. Turecki G. The molecular bases of the suicidal brain. Nat Rev Neurosci 2014; 15: 802–816.

30. O’Connor RC, Nock MK. The psychology of suicidal behaviour. Lancet Psychiatry 2014; 1: 73–85.

31. Haas AP, Eliason M, Mays VM et al. Suicide and suicide risk in lesbian, gay, bisexual, and transgender populations: review and recommendations. J Homosex 2011; 58: 10–51.

32. Fergusson DM, Woodward LJ, Horwood LJ. Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychol Med 2000; 30: 23–39.

33. Brezo J, Paris J, Vitaro F et al. Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry 2008; 193: 134–139.

34. Heim C, Shugart M, Craighead WE, Nemeroff CB. Neurobiological and psychiatric consequences of child abuse and neglect. Dev Psychobiol 2010; 52: 671–690.

35. McGowan PO, Sasaki A, D’Alessio AC et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 342–348.

36. Turecki G, Meaney MJ. Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review. Biol Psychiatry 2016; 79: 87–96.

37. Weder N, Zhang H, Jensen K et al. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry 2014; 53: 417–424.

38. Labonté B, Suderman M, Maussion G et al. Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 2012; 69: 722–731.

39. Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 2009; 65: 760–769.

40. Ernst C, Deleva V, Deng X et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry 2009; 66: 22–32.

41. Keller S, Sarchiapone M, Zarrilli F et al. Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 2010; 67: 258–267.

42. Pedersen MG, Mortensen PB, Norgaard-Pedersen B, Postolache TT. Toxoplasma gondii infection and self-directed violence in mothers. Arch Gen Psychiatry 2012; 69: 1123–1130.

43. Arling TA, Yolken RH, Lapidus M et al. Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders. J Nerv Ment Dis 2009; 197: 905–908.

44. Flegr J. How and why Toxoplasma makes us crazy. Trends Parasitol 2013; 29: 156–163.

45. McGirr A, Renaud J, Bureau A et al. Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide. Psychol Med 2008; 38: 407–417.

46. Séguin M, Beauchamp G, Robert M et al. Developmental model of suicide trajectories. Br J Psychiatry 2014; 205: 120–126.

47. Yang B, Clum GA. Childhood stress leads to later suicidality via its effect on cognitive functioning. Suicide Life Threat Behav 2000; 30: 183–198.

48. Sinclair JM, Crane C, Hawton K, Williams JM. The role of autobiographical memory specificity in deliberate self-harm: correlates and consequences. J Affect Disord 2007; 102: 11–18.

49. Lee FS, Heimer H, Giedd JN et al. Mental health. Adolescent mental health − opportunity and obligation. Science 2014; 346: 547–549.

50. van den Bos R, Harteveld M, Stoop H. Stress and decision-making in humans: performance is related to cortisol reactivity, albeit differently in men and women. Psychoneuroendocrinology 2009; 34: 1449–1158.

51. Williams JM, Barnhofer T, Crane C, Beck AT. Problem solving deteriorates following mood challenge in formerly depressed patients with a history of suicidal ideation. J Abnorm Psychol 2005; 114: 421–431.

52. McGirr A, Diaconu G, Berlim MT et al. Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide. J Psychiatry Neurosci 2010; 35: 399–408.

53. Grover KE, Green KL, Pettit JW et al. Problem solving moderates the effects of life event stress and chronic stress on suicidal behaviors in adolescence. J Clin Psychol 2009; 65: 1281–1290.

54. Arsenault-Lapierre G, Kim C, Turecki G. Psychiatric diagnoses in 3275 suicides: a meta-analysis. BMC Psychiatry 2004; 4: 37.

55. Hoertel N, Franco S, Wall MM et al. Mental disorders and risk of suicide attempt: a national prospective study. Mol Psychiatry 2015; 20: 718–726.

56. Holma KM, Haukka J, Suominen K et al. Differences in incidence of suicide attempts between bipolar I and II disorders and major depressive disorder. Bipolar Disord 2014; 16: 652–661.

57. Angst F, Stassen HH, Clayton PJ, Angst J. Mortality of patients with mood disorders: follow-up over 34-38 years. J Affect Disord 2002; 68: 167–181.

58. Sharifi V, Eaton WW, Wu LT et al. Psychotic experiences and risk of death in the general population: 24−27 year follow-up of the Epidemiologic Catchment Area study. Br J Psychiatry 2015; 207: 30–36.

59. Hor K, Taylor M. Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol 2010; 24: 81–90.

60. Nock MK, Hwang I, Sampson NA, Kessler RC. Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication. Mol Psychiatry 2010; 15: 868–876.

61. Tyrer P, Reed GM, Crawford MJ. Classification, assessment, prevalence, and effect of personality disorder. Lancet 2015; 385: 717–726.

62. Ernst C, Lalovic A, Lesage A et al. Suicide and no axis I psychopathology. BMC Psychiatry 2004; 4: 7.

63. Conner KR, Beautrais AL, Brent DA et al. The next generation of psychological autopsy studies. Part I. Interview content. Suicide Life Threat Behav 2011; 41: 594–613.

64. Kim C, Lesage A, Seguin M et al. Patterns of co-morbidity in male suicide completers. Psychol Med 2003; 33: 1299–1309.

65. Akechi T, Iwasaki M, Uchitomi Y, Tsugane S. Alcohol consumption and suicide among middle-aged men in Japan. Br J Psychiatry 2006; 188: 231–236.

66. Park JE, Lee JY, Jeon HJ et al. Age-related differences in the influence of major mental disorders on suicidality: a Korean nationwide community sample. J Affect Disord 2014; 162: 96–101.

67. Conwell Y, Duberstein PR, Cox C et al. Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study. Am J Psychiatry 1996; 153: 1001–1008.

68. Phillips MR, Yang G, Zhang Y et al. Risk factors for suicide in China: a national case-control psychological autopsy study. Lancet 2002; 360: 1728–1736.

69. Rajkumar R, Fam J, Yeo EY, Dawe GS. Ketamine and suicidal ideation in depression: jumping the gun? Pharmacol Res 2015; 99: 23–35.

70. Black C, Miller BJ. Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients. Biol Psychiatry 2015; 78: 28–37.

71. Turecki G. Polyamines and suicide risk. Mol Psychiatry 2013; 18: 1242–1243.

72. Nemeroff CB, Owens MJ, Bissette G et al. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry 1988; 45: 577–579.

73. Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psychiatry 2000; 48: 766–777.

74. Bernard R, Kerman IA, Thompson RC et al. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psychiatry 2011; 16: 634–646.

75. Ernst C, Nagy C, Kim S et al. Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry 2011; 70: 312–319.

76. Asberg M, Thorén P, Träskman L et al. “Serotonin depression”—a biochemical subgroup within the affective disorders? Science 1976; 191: 478–480.

77. Arango V, Underwood MD, Mann JJ. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 2002; 136: 443–453.

78. Sullivan GM, Oquendo MA, Milak M et al. Positron emission tomography quantification of serotonin(1A) receptor binding in suicide attempters with major depressive disorder. JAMA Psychiatry 2015; 72: 169–178.

79. Brezo J, Bureau A, Mérette C et al. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. Mol Psychiatry 2010; 15: 831–843.

80. Sequeira A, Mamdani F, Ernst C et al. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One 2009; 4: e6585.

81. Choudary PV, Molnar M, Evans SJ et al. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 2005; 102: 15653–15658.

82. Rajkumar R, Fam J, Yeo EY, Dawe GS. Ketamine and suicidal ideation in depression: jumping the gun? Pharmacol Res 2015; 99: 23–35.

83. Wenzel A, Brown GK, Beck AT. Classification and assessment of suicide ideation and suicidal acts. In: Wenzel A, Brown GK, Beck AT (eds.). Cognitive therapy for suicidal patients: Scientific and clinical applications. American Psychological Association, Washington, DC, 2009, s. 377.

84. Moller-Leimkuhler AM. Barriers to help seeking by men: A review of sociocultural and clinical literature with particular reference to depression. J Affect Disord 2002; 71: 1–9.

85. McKelvey RS, Pfaff JJ, Acres JG. The relationship between chief complaints, psychological distress, and suicidal ideation in 15–24 year-old patients presenting to general practitioners. Med J Aust 2001; 175: 550–552.

86. Busch KA, Fawcett J, Jacobs DJ. Clinical correlates of inpatient suicide. J Psychiatry 2003; 64: 14–19.

87. Louma JB, Martin CE, Pearson JL. Contact with mental health and primary care providers before suicide: A review of the evidence. Am J Psychiatry 2002; 159: 909–916.

88. Feldman MD, Duberstein PR, Vannoy S et al. Let’s not talk about it: Suicide inquiry in primary care. Ann Fam Med 2007; 5: 412–418.

89. Saunders K, Brand F, Lascelles K, Hawton K. The sad truth about the SADPERSONS Scale: An evaluation of its clinical utility in self-harm patients. Emerg Med J 2013; 31: 796–798.

90. Harris KM, Syu JJ, Lello OD et al. The ABC’s of suicide risk assessments: Applying a tripartite approach to individual encounters. PLoS One 2015; 10: e0127442.

91. Bajaj P, Borreani E, Ghosh P et al. Screening for suicidal thoughts in primary care: The views of patients and general practitioners. Mental Health Fam Med 2008; 5: 229–235.

92. Vail L, Adams A, Gilbert E et al. Investigating mental health risk assessment in primary care and the potential role of a structured decision support tool, GRIST. Ment Health Fami Medi 2012; 9: 57–67.

93. Mott JA. An integrated approach to estimating suicide risk. Suicide Life Threat Behav 1991; 21: 74–89.

94. Chan WI, Batterham P, Christensen H, Galletly C. Suicide literacy, suicide stigma, and help-seeking intentions in Australian medical students. Australas Psychiatry 2014; 22: 132–139.

95. Graham RD, Rudd D, Bryan CJ. Primary care providers’ views regarding assessing and treating suicidal patients. Suicide Life Threat Behav 2011; 41: 614–623.

96. Gunnell D, Bennewith O, Peters TJ et al. Do patients who self-harm consult their general practitioner soon after hospital discharge? A cohort study. Soc Psychiatry Psychiatr Epidemiol 2002; 37: 599–602.

97. Marquet RL, Bartelds AI, Kerkhof AJ et al. The epidemiology of suicide and attempted suicide in Dutch general practice 1983–2003. BMC Fam Pract 2005; 6: 45.

98. Poma SZ, Grossi A, Toniolo E et al. Self-perceived difficulties with suicidal patients in a sample of Italian general practitioners. J Clin Med Res 2011; 3: 303–308.

99. Olfson M, Weissman MM, Leon AC et al. Suicidal ideation in primary care. J Gen Intern Med 1996; 11: 447–453.

100. Riihimaki K, Vuorilehto M, Melartin T et al. Incidence and predictors of suicide attempts among primary-care patients with depressive disorders: a 5-year prospective study. Psychol Med 2014; 44: 291–302.

101. Houston K, Haw C, Townsend E, Hawton K. General practitioner contacts with patients before and after deliberate selfharm. Br J Gen Pract 2003; 53: 365–370.

102. Raue PJ, Brown EL, Meyers BS et al. Does every allusion to possible suicide require the same response? J Fam Pract 2006; 55: 605–612.

103. Fanello S, Paul P, Delbos V et al. General practitioners’ practices and attitudes in regard to suicidal behavior. Santé Publique 2002; 14: 263–273.

104. Verger P, Brabis PA, Kovess V et al. Determinants of early identification of suicidal ideation in patients treated with antidepressants or anxiolytics in general practice: a multilevel analysis. J Affect Disord 2007; 99: 253–257.

105. Mitchell AJ, Vaze A, Rao S. Clinical diagnosis of depression in primary care: a meta-analysis. Lancet 2009; 374: 609–619.

106. Kroenke K, Spitzer RL, Williams JB et al. Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment. Arch Fam Med 1994; 3: 774–779.

107. Benca R, Peterson M. Insomnia and depression. Sleep Medicine 2008; 9(Suppl. 1): S3–S9.

108. Perlis ML, Giles DE, Buysse DJ et al. Self-reported sleep disturbance as a prodromal symptom in recurrent depression. J Affect Disord 1997; 42: 209–212.

109. National Institute for Health and Care Excellence. NICE clinical guideline 90 Depression: The treatment and management of depression in adults. 2009.

110. Arroll B, Khin N, Kerse N. Screening for depression in primary care with two verbally asked questions: cross sectional study. BMJ 2003; 327:1144–1146.

111. U.S. Preventive Services Task Force. Screening for depression: recommendations and rationale. Ann Intern Med 2002; 136(10): 760–764.

112. Kroenke K, Spitzer RL, Williams JB. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 2003; 41: 1284–1292.

113. Williams JW Jr, Noel PH, Cordes JA et al. Is this patient clinically depressed? JAMA 2002; 287: 1160–1170.

114. Rush AJ, Trivedi MH, Ibrahim HM et al. The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry 2003; 54: 573–583.

115. Beck AT, Steer RA, Ball R, Ranieri W. Comparison of Beck Depression Inventories-IA and-II in psychiatric outpatients. J Pers Assess 1996; 67: 588–597.

116. Van Marwijk HW, Wallace P, de Bock GH et al. Evaluation of the feasibility, reliability and diagnostic value of shortened versions of the geriatric depression scale. Br J Gen Pract 1995; 45: 195–199.

117. Zung WW. Factors influencing the self-rating depression scale. Arch Gen Psychiatry 1967; 16: 543–547.

118. Mueller TI, Leon AC, Keller MB et al. Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry 1999; 156: 1000–1006.

119. Caspi A, Sugden K, Moffitt TE et al. Influence of life stress on expression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386–389.

120. Katon W, Lin EH, Kroenke K. The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 2007; 29: 147–155.

121. Ladin K, Daniels N, Kawachi I. Exploring the relationship between absolute and relative position and late-life depression: evidence from 10 European countries. Gerontologist 2010; 50: 48–59.

122. Lorant V, Croux C, Weich S et al. Depression and socio-economic risk factors: 7-year longitudinal population study. Br J Psychiatry 2007; 190: 293–298.

123. Meltzer H, Bebbington P, Brugha T et al. Job insecurity, socio-economic circumstances and depression. Psychol Med 2010; 40: 1401–1407.

124. Freeman EW, Sammel MD, Lin H et al. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry 2006; 63: 375–382.

125. Desjardins I, Cats-Baril W, Maruti S et al. Suicide risk assessment in hospitals: an expert system-based triage tool. J Clin Psychiatry 2016; 77: e874–882.

126. Swedish Council on Health Technology Assessment. Instruments for suicide risk assessment. SBU, Stockholm, 2015.

127. Suicide risk assessment and the Columbia-Suicide Severity Rating Scale (C-SSRS). Dostupné na: www.youtube.com/watch?v=Xfddz_Yfnc4

128. WHO. Preventing suicide. A global imperative. World Health Organization, 2014.

129. WHO. Preventing suicide. A resource for general physicians. Mental and behavioural disorders. World Health Organization, Geneva, 2000.

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