MicroRNAs and kidneys

Czech version

Authors: Jana Stříteská ¹; Jana Nekvindová ²; Vladimír Černý ³; Vladimír Palička ⁴
Authors‘ workplace: Univerzita Karlova v Praze, Lékařská fakulta, Hradec Králové ; Dalhousie University, Department of Anesthesia, Pain Management and Perioperative Medicine, Halifax, Canada ; Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové ; Ústav molekulární a translační medicíny, Lékařská fakulta Univerzity Palackého, Olomouc ; Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice, Hradec Králové ¹; Ústav klinické biochemie a diagnostiky, Fakultní nemocnice, Hradec Králové ²; Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice, Hradec Králové ³; Ústav klinické biochemie a diagnostiky, Fakultní nemocnice Hradec Králové ⁴
Published in: Čas. Lék. čes. 2014; 153: 187-192
Category: Review Articles

Overview

MicroRNAs are short non-coding ribonucleic acid molecules that regulate gene expression at the post-transcriptional level thus affecting important physiological as well as pathophysiological processes in the organism, for example cell differentiation, proliferation, apoptosis, and metabolism. They are involved in pathogenesis of many diseases including cancer. Many microRNAs are tissue or organ-specific which implies their possible potential as biomarkers or maybe even therapeutical agents as documented by microRNA research interest rising exponentially during last years. Among all, microRNAs are important also for physiological function of the kidney and they are involved in various renal disorders. Today research is focused mainly on renal and urinary tract carcinogenesis, acute kidney injury, chronic renal diseases (polycystic kidney disease) or renal complications of systemic diseases such as diabetic or hypertension nephropathy and autoimmune kidney injury including acute allograft rejection after kidney transplantation. The review summarizes current information about microRNA effect on kidney development and function and also on the most common kidney diseases.

Keywords:
microRNA – acute kidney injury – diabetic nephropathy – gene expression profiles – biomarkers

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management

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Article was published in

Journal of Czech Physicians

2014 Issue 4

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