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proLékaře.cz / Journals / Internal Medicine / 2023 - E-5

Selected biomarkers of orthostatic intolerance

Czech version

Authors: Barbora Bačkorová;  Ivica Lazúrová
Authors‘ workplace: 1. interná klinika UNLP a UPJŠ LF Košice
Published in: Vnitř Lék 2023; 69(E-5): 15-19
Category:
doi: https://doi.org/10.36290/vnl.2023.066

Overview

Orthostatic intolerance (OI) is defined as a group of diseases which symptoms are typically manifested in a standing position. These symptoms result from cerebral hypoperfusion and disappear in the supine position. We include postural orthostatic intolerance syndrome (POTS), orthostatic hypotension (OH) and vasovagal orthostatic syncope in this group of diseases. Each of them have similar clinical presentation (blurred vision, weakness, dizziness, nausea, headaches, fatigue). However, they vary from each other in biochemical, autonomic and hemodynamic characteristics.

The aim of the work is to provide an overview of humoral and non-human markers that are involved in the etiopathogenesis of orthostatic intolerance.

Keywords:

biomarkers – POTS – orthostatic intolerance – vasovagal syncope

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