Authors: J. Horáček Authors‘ workplace: Psychiatrické centrum Praha, ředitel prof. MUDr. C. Hóschl, DrSc. Published in: Čes. a slov. Psychiat., , 2001, No. 5, pp. 240-246. Category:
Preparation LI 160 (Jarsin©) is a standardized extract of Hypericum perforatum L. Its antidepressant effect was proved in controlled studies with placebo and standard antidepressants in mildand medium severe depressions. In larger doses its effect was tested also in severe depressions. Inlarger doses its effect was tested also in severe depressions. It has a very favourable profile asregards undesirable effects and is not cardiotoxic. Due to induction of enzyme P450, interactionswith drugs which are brokem down by this system are possible. Most probably the mechanism ofthe antidepressant action of LI 160 is mediated by a combined block of serotonin, noradrenalineand dopamine uptake.
Key words: Hypericum perforatum, antidepressant, hyperforin.
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