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Diazotační titrace v lékopisné kontrole jakosti léčiv a návrhy pro jejich revizi v Evropském lékopisu*

Czech version

Authors: Jan Šubert;  Jozef Kolář;  Jozef Čižmárik
Authors‘ workplace: Katedra farmaceutickej chémie FaF Univerzita Komenského v Bratislave, Slovenská republika ;  Ústav aplikované farmacie Farmaceutická fakulta, Masarykova univerzita
Published in: Čes. slov. Farm., 2023; 72, 165-171
Category: Review Articles
doi: https://doi.org/10.5817/CSF2023-4-165

Overview

Based on the data in the Ph. Eur., some other newer pharmacopoeias and published experimental papers propose to revise the text of Ph. Eur. 2.5.8. First, it is necessary to specify which of the electrometric methods should be used to indicate the endpoint of diazotization titrations in Ph. Eur. (preferable potentiometry with a platinum indicating electrode). The amount of potassium bromide in the titration solution may be reduced to 1 g, the cooling of the solution before titration may be omitted from the framework procedure, and it may be specified in individual monographs if necessary to obtain accurate and correct results for some medicines. Diazotization titration can be performed in Ph. Eur. and can also be used to determine the content of some other medicines.

Keywords:

titration of medicines with sodium nitrite • end-point indication • other conditions • Ph. Eur.

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