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10 Properties and Benefits of Gliptins: How They Work and When to Prescribe Them

28. 8. 2020 Source: Diabetes

General practitioners can now prescribe oral antidiabetics from the group of gliptins to patients with type 2 diabetes. Their therapeutic options are significantly expanded in the care of these patients. In the following text, we briefly summarize the mechanism of action of gliptins and their advantages over other oral antidiabetics.

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Population Pharmacokinetics of Perioperative Administration of Coagulation Factors in Patients with von Willebrand Disease

For many patients with von Willebrand disease, the administration of coagulation factors is an important part of perioperative care. Due to the absence of pharmacokinetic models, predicting…
27. 8. 2020 Source: Von Willebrand Disease
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Evaluation of Various VWF Concentrates Regarding Their Ability to Mediate Platelet Binding to Collagen

The study by London researchers on various VWF concentrates focused, among other things, on evaluating their ability to mediate platelet binding to collagen.
27. 8. 2020 Source: Von Willebrand Disease
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Improvement of Joint and Skin Symptoms and Their Contribution to Improving the Quality of Life in Patients with Psoriatic Arthritis

The cause of reduced quality of life in patients with psoriatic arthritis is the involvement of both skin and joints. Commonly used therapy certainly improves symptoms of both systems to some extent,…
21. 8. 2020 Source: Biological Treatment
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Safety Analysis of Baricitinib in Long-Term Treatment of Rheumatoid Arthritis

Janus kinase inhibitors are relatively new and very promising drugs, but their novelty also raises the question: Are they really safe? A brand-new analysis provides the answer by examining a cohort…
21. 8. 2020 Source: Biological Treatment
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Efficacy and Tolerance of Dorzolamide/Timolol Combination With and Without Preservatives in Patients With Elevated Intraocular Pressure

The fixed combination of the carbonic anhydrase inhibitor dorzolamide and the locally acting beta-blocker timolol is indicated for the treatment of elevated intraocular pressure in patients with…
21. 8. 2020 Source: Treatment of Glaucoma
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Self-administration of alpha-1-antitrypsin can significantly improve patients' quality of life

Treatment of alpha-1 antitrypsin deficiency (AATD) requires lifetime administration of weekly intravenous infusions of this substance, mostly in medical facilities. The possibility of AAT application…
20. 8. 2020 Source: Deficiency of Alpha-1-Antitrypsin
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Treatment of Glaucoma: Without Preservatives for Everyone?

A comprehensive report by Professor John Thygesen from the University Hospital in Copenhagen analyzes patient groups for whom preservative-free antiglaucoma medications are particularly suitable. In…
20. 8. 2020 Source: Treatment of Glaucoma
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Pharmacokinetics and Safety of Bilastine 10 mg in Children Aged 6–11 Years

The second-generation antihistamine bilastine is approved in Europe for the treatment of allergic rhinoconjunctivitis and urticaria from the age of 6 years. Recently, results from two post hoc…
17. 8. 2020 Source: Allergic Reactions
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Safety and Tolerability of Bilastine in the Treatment of Chronic Urticaria in Children

Chronic urticaria is less common in pediatric patients compared to the acute form, but it always requires therapy due to bothersome chronic symptoms that reduce quality of life and disrupt daily…
17. 8. 2020 Source: Allergic Reactions
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Transition of Hemophilia A Patients with a History of Coagulation Factor Inhibitor to Emicizumab

During the World Federation of Hemophilia (WFH) conference, held virtually in June 2020, interesting results were presented for patients with Hemophilia A who had a history of FVIII inhibitor and are…
3. 8. 2020 Source: Quality Life Even with Hemophilia
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DPP-4 Inhibitors May Prevent SARS-CoV-2 Entry into Cells

Since the new type of coronavirus SARS-CoV-2 utilizes the DPP-4 receptor to enter human cells, DPP-4 inhibition by gliptins could represent a potential approach to pharmacological treatment of…
3. 8. 2020 Source: Diabetes
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An Introductory Word to the Section on Hereditary Angioedema —⁠ MUDr. Roman Hakl, Ph.D.

Hereditary angioedema (HAE) is a genetically conditioned disease, currently classified into HAE with C1 inhibitor deficiency (HAE-C1-INH), referred to as HAE-I and HAE-II, and HAE with normal level…
29. 7. 2020 Source: Hereditary Angioedema
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Algorithm for Choosing Antidiabetics in Patients with Type 2 Diabetes

As of June 1, 2020, general practitioners can prescribe antidiabetics from the group of so-called gliptins, inhibitors of the enzyme dipeptidyl peptidase 4 (DPP-4i), in addition to metformin. The…
29. 7. 2020 Source: Diabetes
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Major Orthopedic Procedures in Patients with Inhibitor Treated with Emicizumab

Italian authors presented the results of a study of a small series of hemophilia patients with inhibitors treated with emicizumab, who underwent major orthopedic surgery, at the World Federation of…
28. 7. 2020 Source: Quality Life Even with Hemophilia
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