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Comparison of the Efficacy of Tofacitinib and Vedolizumab in the Treatment of Ulcerative Colitis After Anti-TNF Therapy Failure

21. 8. 2022 Source: Intestinal Inflammations

Therapeutic options for ulcerative colitis resistant to anti-TNF-α antibody treatment are available, but there were no studies comparing the selective immunosuppressants tofacitinib and vedolizumab in this patient population. The aim of this comparison was a multicenter French study, the first results of which were presented at the 17th ECCO Congress 2022.

Osteopenie kost

Bone density in hemophiliacs −⁠ known and less-known risk factors

Osteopenia or osteoporosis are known comorbidities of hemophilia and concern many of these patients. What all contributes to their development?
20. 8. 2022 Source: Hemophilia
Cerebrovaskulárního

Turoctocog Alfa in Tertiary Prophylaxis of Hemophilia A or Is It Always About Bleeding? Case Studies

This case report from our own practice concerns our experience with the treatment of hemophilia A with turoctocog alfa. The intention is, among other things, to compare different outcomes in our two…
19. 8. 2022 Source: Hemophilia with Movement
nádor výzkum léčby rakoviny

Nearly 20 Years with Bevacizumab Has Brought Hope for Patients and Deeper Understanding of Solid Tumors

Bevacizumab is among the first targeted therapies used in oncology. For many indications where chemotherapy options had been exhausted and few other treatment modalities were available, it changed…
19. 8. 2022 Source: Oncological Treatment
Muž_deprese

Lurasidone in Antipsychotic Therapy –⁠ A Case Study of a Virtual Patient from the Laurie Project

MUDr. Elis Bartečků, Ph.D., from the Department of Psychiatry at MU LF and FN Brno presented the current possibilities of telemedical education at the XIV congress of the Psychiatric Society of the…
18. 8. 2022 Source: Modern Treatment of Schizophrenia
obezita a deprese

Complex Impacts of Obesity on the Brains of People with Psychiatric Disorders

Obesity in individuals with bipolar disorder or schizophrenia is closely linked not only to higher mortality but also to worse progression of the psychiatric illness, lower response to psychiatric…
18. 8. 2022 Source: Modern Treatment of Schizophrenia
čas a krev

Time is Blood! Impact of Diagnostic Delays on Prognosis of Patients with Acquired Hemophilia A

The famous slogan of neurologists in connection with strokes –⁠ 'Time is brain!' –⁠ can be modified to 'Time is blood!' for the issue of acquired hemophilia A (AHA). The factor of time plays a crucial…
16. 8. 2022 Source: Hemophilia
krvácení z nosu

Urgent Administration of Romiplostim in Life-Threatening Bleeding Associated with ITP

Recommendations for the care of acute, especially major bleeding in individuals with severe immune thrombocytopenia (ITP) are not entirely clear. Various methods (steroid boluses, intravenous…
10. 8. 2022 Source: Immune Thrombocytopenia
medicínská studie 2

Consensus on the Administration of TPO-RA as Second-Line Therapy in ITP

What is the role of thrombopoietin receptor agonists (TPO-RA) in the second line treatment of patients with immune thrombocytopenia (ITP)? Italian authors conducted a survey using the Delphi method…
10. 8. 2022 Source: Immune Thrombocytopenia
velkobuněčný difuzní lymfom

Brentuximab vedotin in combination with lenalidomide and rituximab in R/R DLBCL –⁠ results from the open part of the ECHELON-3 study

The aim of the open run-in phase of the randomized placebo-controlled phase III ECHELON-3 study, the results of which were presented at the ASCO and EHA 2022 congresses, was to evaluate the efficacy…
10. 8. 2022 Source: Hematologic Malignancies
pacient s klasickým Hodgkinovým lymfomem

6-year data from the ECHELON-1 study: How does combining brentuximab vedotin with chemotherapy affect overall survival of previously untreated cHL patients?

At this year's annual congress of the European Hematology Association (EHA), results from the analysis of 6-year data from the international randomized open-label phase III ECHELON-1 study on overall…
10. 8. 2022 Source: Hematologic Malignancies
amputovana noha

How to Save a Leg from Amputation?

Feared complications in diabetics include defects in typical locations on the lower limbs. Their presence and frequent recurrences increase the risk of possible amputation of varying degrees, mainly…
10. 8. 2022 Source: Wound Healing
lékař radost malý kluk a matka

Prophylaxis EHL products FVIII bring improvements in clinical and pharmacokinetic results

A freshly published real-world clinical practice study from Spain highlights the experience of switching patients with hemophilia A in a prophylaxis setting from standard half-life products to newer…
8. 8. 2022 Source: Hemophilia
Emotional joyful patient telling his doctor good news

Benefit of Adding Empagliflozin to Standard Therapy in Heart Failure with Reduced Ejection Fraction

The use of empagliflozin led to a reduction in the risk of hospitalization for heart failure or death from cardiovascular (CV) causes in the EMPEROR-Reduced study in patients with adequately treated…
5. 8. 2022 Source: Heart Failure
venclyxto kazuistika

Sequential administration of immunochemotherapy and venetoclax after failure of BCR inhibitor treatment –⁠ interactive video case study

The treatment of chronic lymphocytic leukemia (CLL) is evolving. What was impossible years ago is now becoming a reality. From chemotherapy, through immunochemotherapy, to the use of molecules…
5. 8. 2022 Source: Chronic Lymphocytic Leukemia
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