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When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?
2. 5. 2023 Source: Rare Diseases in NeurologyMyasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is essential because treatment can lead to permanent remission and full functional capacity of the patient.
Sjögren's Syndrome as a Cause of Dry Eye Syndrome
Primary Sjögren's syndrome represents a complex autoimmune disease primarily affecting glands with exocrine secretion. Dry eye syndrome ranks among the most common difficulties for patients with…2. 5. 2023 Source: Ophthalmologic Diseases
Infographic and Commentary from Practice: Reasons and Pathways for Patients to Biological Treatment of Asthma
For asthma patients with the most severe forms of the disease to access targeted biological treatment, they must undergo examination at one of the specialized centers for severe asthma. To facilitate…
Subcutaneous pdC1-INH in Patients with Hereditary Angioedema in Real-World Practice
Italian authors published a series of cases of patients with hereditary angioedema caused by C1 inhibitor deficiency (C1-INH-HAE) with long-term prophylaxis using human plasma-derived C1 inhibitor concentrate...27. 4. 2023 Source: Hereditary Angioedema
Efficacy and Safety of an Activated FXII Inhibitor in Preventing HAE Attacks
Hereditary angioedema (HAE) is a rare, potentially life-threatening inherited disorder characterized by dysregulation of the kallikrein-kinin system. This results in excessive production of bradykinin,...27. 4. 2023 Source: Hereditary Angioedema
To what extent does the delay between symptom onset and diagnosis of AATD affect patient survival?
The risk of chronic obstructive pulmonary disease (COPD) is increased, among other things, by a deficiency of alpha-1-antitrypsin (AATD). However, there is often a delay between the onset of symptoms...26. 4. 2023 Source: Deficiency of Alpha-1-Antitrypsin
Benefits and Cost-Effectiveness of Superabsorbent Dressings in the Treatment of Venous Leg Ulcers
A recent cost-effectiveness analysis based on German data showed that using superabsorbent dressings instead of conventional dressings in the treatment of venous leg ulcers with moderate to high…26. 4. 2023 Source: Wound Healing
Brain implants can affect the human mind in a surprising way
The technology company Neuralink, owned by Elon Musk, announced in December 2022 that it plans to start clinical testing of an electronic chip to be implanted in the skull within six months. However,…26. 4. 2023 Source: proLékaře.cz
Absorption of Levothyroxine: What Has the New Formulation of LT4-Containing Medicinal Products Brought?
Lifelong use of levothyroxine (LT4) is the cornerstone of hypothyroidism treatment. The narrow therapeutic range of LT4 places increased emphasis on accurate dosing and appropriate titration, making…26. 4. 2023 Source: Thyroid Disorders
Subclinical Hypothyroidism in Pregnancy: How Great Are the Real Risks and Can They Be Effectively Reduced?
The aim of the meta-analysis by authors from the Mayo Clinic was to describe the impact of subclinical hypothyroidism on the course of pregnancy and the effect of levothyroxine replacement therapy in…25. 4. 2023 Source: Thyroid Disorders
Adherence to Treatment of Multiple Sclerosis: How to Enhance It and What Interesting Insights Emerged from Current Research?
Therapeutic options for patients with multiple sclerosis (MS) utilizing disease-modifying drugs (DMDs) have continued to expand in recent years. However, achieving their full benefit is critically dependent...24. 4. 2023 Source: Multiple Sclerosis
Teriflunomide in the Treatment of RRMS: The Best Working Drug Is the One That the Patient Actually Takes
Teriflunomide is an oral disease-modifying drug (DMD) used in the therapy of relapsing-remitting multiple sclerosis (RRMS). The authors of the cited American study assessed adherence to this treatment...24. 4. 2023 Source: Multiple Sclerosis
Early Tumor Regression as a Marker of Overall Survival in First-Line Treatment of mCRC
In the treatment of metastatic colorectal cancer (mCRC), prognostic factors besides overall survival (OS) and progression-free survival (PFS) include early tumor regression (ETS) and depth of…21. 4. 2023 Source: Colorectal Cancer
Meta-Analysis of the Results of Studies Comparing the Effectiveness of Manual and Sonic Toothbrushes
Brushing teeth is a fundamental means of maintaining good oral hygiene. While many people still rely on using manual toothbrushes, brushing with electric toothbrushes has also gradually gained…21. 4. 2023 Source: Dental Care
Is Obesity a Universal Phenotype in Children with Type 2 Diabetes?
What is the global prevalence of obesity in children and adolescents suffering from type 2 diabetes mellitus (T2DM)? Does the occurrence of obesity in pediatric T2DM correlate with gender or race?…19. 4. 2023 Source: Modern Treatment of Diabetes
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