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Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?
4. 3. 2024 Source: Heart FailureThe Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of heart failure with preserved ejection fraction of the left ventricle (HFpEF). Recent studies in this heterogeneous disease suggest the importance of carefully determining the HFpEF phenotype in a given patient based on pathophysiology, which enables better individualization of treatment. The authors also reflect on the success…
Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab
The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief…
Digital Bridge Between the Brain and Spine: How an Implant Restored Walking Ability to a Paralyzed Patient − Case Study
When a spinal cord injury occurs, communication between the brain and peripheral nerves is interrupted, causing paralysis. Until recently, it was not possible to restore mobility for most of these…4. 3. 2024 Source: proLékaře.cz
A Cloned Monkey Survived to Adulthood for the First Time. Will We Soon Be Able to Clone Humans?
A macaque named ReTro, born as a result of a cloning experiment by Chinese scientists, has reached adulthood. This is the first such successful cloning that could pave the way for further primate…4. 3. 2024 Source: proLékaře.cz
Can we properly manage osteoporotic fractures?
Osteoporotic fractures are associated with increased morbidity and mortality and often lead to an overall deterioration in the quality of life. We should not forget to diagnose osteoporosis in…29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy
Meta-analysis of the Effectiveness of Romosozumab in the Treatment of Postmenopausal Osteoporosis
Osteoporosis is a prevalent disease with unmet therapeutic needs. Whether the anti-sclerostin antibody romosozumab can offer an effective improvement in osteoporosis treatment outcomes in…29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy
Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome – A Case Study
Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for…27. 2. 2024 Source: Modern Treatment of Schizophrenia
Clinical Significance of Smaller Gaps Between Strengths of Levothyroxine Preparations in the Treatment of Hypothyroidism
Many levothyroxine preparations have relatively large intervals between doses (25 µg, 50 µg, and 75 µg), creating obstacles for some patients to achieve an optimal maintenance dose. The availability…23. 2. 2024 Source: Thyroid Disorders
Generic Substitution of Levothyroxine in Practice
The active ingredient levothyroxine is found in a significant number of medicinal products (MP) in the Czech Republic. The question of its generic substitution remains current, primarily because the…22. 2. 2024 Source: Thyroid Disorders
Options for Systemic Therapy of Advanced Stage Small Cell Lung Cancer
Small cell lung cancer (SCLC) is the most aggressive type of lung tumor. Although it responds well to chemotherapy and radiotherapy, due to the early onset of treatment resistance, the 5-year…22. 2. 2024 Source: Small Cell Lung Cancer
Current Sequence of Treatment for Metastatic HER2+ Breast Cancer
In September 2023, experts from Miami Cancer Institute published their consensus statement on the treatment of HER2-positive advanced breast cancer (BC). The latest change in therapeutic strategy is…22. 2. 2024 Source: Ovarian and Breast Cancer
Artificial Intelligence and Deep Learning as the Future of Glaucoma Diagnosis
Glaucoma represents a group of eye diseases characterized by changes to the optic nerve. It is the second most common cause of blindness, currently affecting more than 90 million people worldwide. It…21. 2. 2024 Source: proLékaře.cz
MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life
Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them…21. 2. 2024 Source: Quick aid for acute convulsive seizures in children and adolescents
IEC 2023: Key Challenges for Epilepsy Patients Include Status Epilepticus and Anxiety Management
Why is anxiety a significant issue for epilepsy patients? What do current insights say about the connection between epilepsy and anxiety? Can artificial intelligence be used to predict status…21. 2. 2024 Source: Quick aid for acute convulsive seizures in children and adolescents
Ocrelizumab in the Treatment of Multiple Sclerosis – 10-Year Data
Multiple sclerosis (MS) is a lifelong disease with a high risk of permanent disability. Current information on the long-term efficacy and safety of treatment is therefore absolutely essential for the…20. 2. 2024 Source: Neurology - Multiple Sclerosis
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