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Lorlatinib as an Alternative to CNS Radiotherapy in Patients with NSCLC −⁠ Case Studies

10. 2. 2020 Source: Genetic Profile and Treatment of NSCLC

Two remarkable case studies from authors at the Netherlands Cancer Institute Antoni van Leeuwenhoek in Amsterdam present patients with advanced NSCLC with metastatic CNS involvement. Treatment with crizotinib led to good control of pulmonary involvement but did not affect metastatic CNS involvement. The introduction of lorlatinib subsequently led to rapid improvement in neurological symptoms, which was also confirmed by CNS imaging.

Ledviny a diagnóza

Idarucizumab reverses the anticoagulant effect of dabigatran even in patients with impaired renal function –⁠ clinical practice commentary

Along with the results of a subanalysis of the RE-VERSE AD study, which demonstrated the efficacy of idarucizumab in reversing the anticoagulant effect of dabigatran regardless of the level of renal…
10. 2. 2020 Source: Anticoagulant Treatment
medicína_žena_těhotná_těhotenství_matka

Does The Use of Levothyroxine in Women with Thyroid Peroxidase Antibodies Affect The Risk of Miscarriage and Premature Birth?

Women with thyroid peroxidase antibodies have a higher risk of miscarriage and premature birth, even if they have normal thyroid function. The British study presented below aimed to clarify whether…
10. 2. 2020 Source: Thyroid Disorders
koleno ATTUNE® Knee System

Comparison of Clinical Outcomes of TKA Implantation: ATTUNE vs. SIGMA

The ATTUNE total knee arthroplasty (TKA) system was introduced to the market in 2013 as a successor to the popular SIGMA system. The new type of knee endoprosthesis is designed to provide better…
7. 2. 2020 Source: Large Joints
Pacienti s kašlem a bronchitidou

Clinical Benefit of Mucolytics in the Treatment of Upper Respiratory Tract Infections

A new review based on published controlled and observational studies as well as real-world practice experiences demonstrates the benefits of ambroxol, bromhexine, carbocisteine, erdosteine,…
6. 2. 2020 Source: Cough Therapy

Prevalence and Incidence of Age-Related Macular Degeneration in Europe –⁠ Current Overview and Trend Analysis

A comprehensive review article by authors from Bonn, Germany, published late last year in the British Journal of Ophthalmology, provides current data and estimates of the incidence and prevalence of…
6. 2. 2020 Source: Glaucoma
vysledky_interpretace

Changes in Intestinal Microflora Correlate with Disease Activity in Patients with Lupus Erythematosus

The role of intestinal microflora in the pathogenesis of autoimmune diseases, including lupus erythematosus, has been discussed for a long time. An American study discovered a specific bacterium…
4. 2. 2020 Source: Arthritis
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Risk Factors and Therapy of Chronic Leg Ulcers Lasting More Than 6 Months

The therapy of chronic leg ulcers in diabetics continues to be a significant challenge for attending physicians and surgeons. Authors of a recently published study have addressed the risk factors, clinical...
3. 2. 2020 Source: Wound Healing
LDL cholesterol

LDL cholesterol: a new risk factor for the onset of venous thromboembolic disease?

Not only do atherosclerotic plaques in the arteries and the risk of heart attack decrease along with LDL cholesterol levels. Results from a large molecular genetic study suggest that lowering its…
3. 2. 2020 Source: Cardiovascular Risks

Polatuzumab Vedotin in Combination Treatment of Patients with R/R DLBCL

Polatuzumab Vedotin is a conjugate of a cytostatic agent and an antibody against CD79b, a component of the B-lymphocyte receptor typically expressed by diffuse large B-cell lymphoma (DLBCL) cells. In…
3. 2. 2020 Source: Non-Hodgkin Lymphomas and CLL
zhodnocení výsledků vyšetření u lékaře 2356x1571

End of Unnecessary Biopsies? Prostate Health Index (PHI) in Detecting Aggressive Carcinoma

The Prostate Health Index (PHI) combines the results of three blood-derived parameters: total PSA (tPSA), free PSA (fPSA), and [-2]proPSA (p2PSA) into a single numerical score: PHI = (p2PSA / fPSA ×…
2. 2. 2020 Source: Prostate Health Index
notebook_studie_výzkum_laptop_vzdělávání

Prediction of Cancer Aggressiveness: Prostate Health Index (PHI) as a Promising Future Marker

The Prostate Health Index (PHI) is a diagnostic blood test that combines the levels of prostate-specific antigen (PSA), free PSA (fPSA), and the isoform [-2]proPSA (p2PSA). Its use in prostate cancer…
2. 2. 2020 Source: Prostate Health Index

Cardiovascular Benefit of SGLT2 Inhibitors Confirmed

The cardiovascular (CV) benefit of SGLT2 inhibitors in type 2 diabetics, demonstrated by empagliflozin in the EMPA-REG OUTCOME study, has also been confirmed by studies with canagliflozin (CANVAS), a...
31. 1. 2020 Source: Diabetes
muz_zena_par

Why Do Women in the USA Receive Indicated Statin Therapy Less and in Lower Doses Than Men?

Statin use has been proven to reduce the risk of cardiovascular diseases in both men and women. However, women in the USA who are indicated for this treatment have historically taken it less…
31. 1. 2020 Source: Cardiovascular Risks
obezita_lide_ulice

Efficacy and Safety of High Doses of Enoxaparin in Preventing Thromboembolic Disease in Morbidly Obese Patients

Thromboembolic disease is a significant cause of morbidity and mortality in hospitalized patients, with morbid obesity being a notable risk factor for thromboembolism. Various thromboprophylaxis…
28. 1. 2020 Source: Thromboprophylaxis
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