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Role of Chemoimmunotherapy in the Era of Rapid Development of CLL Treatment Strategies and Emergence of New Drugs

22. 4. 2020 Source: Chronic Lymphocytic Leukemia

In the context of the significant advancements in the field of immunotherapy and evidence of its efficacy in the treatment of chronic lymphocytic leukemia, it is pertinent to ask how this will influence therapeutic strategies in the context of first-line treatment and what the role of chemoimmunotherapy will be in the algorithms for CLL. At the 2019 NCCN Annual Congress, a panel of experts, led by Professors William G. Wierda from Texas MD Anderson Cancer Center and Jennifer R. Brown from Dana-Farber Cancer Institute, debated this topic.

Recommendations for the diagnosis of ITP in adults and children according to ASH guidelines

The American Society of Hematology (ASH) guidelines from 2019 highlighted several important aspects in the diagnosis and treatment of ITP that have remained unchanged from the 2011 guidelines.

22. 4. 2020 Source: Immune Thrombocytopenia

Current ASH Guidelines on ITP Management 2019 –⁠ Recommendations for Newly Diagnosed ITP in Children

At the end of 2019, the American Society of Hematology (ASH) published current guidelines for immune thrombocytopenia (ITP), in which a panel of experts attempted to define evidence-based…

22. 4. 2020 Source: Immune Thrombocytopenia

Clinical Results of the Pinnacle Acetabular System: Data from the UK Joint Replacement Registry

The Pinnacle Acetabular System has been available on the market for nearly two decades. Since then, it has been implanted in numerous healthcare facilities worldwide. Clinical outcomes of the…

22. 4. 2020 Source: Large Joints

Incontinence Dermatitis -⁠ Common, Yet Often Overlooked Diagnosis

Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis.…

21. 4. 2020 Source: Incontinence

Through Obstacles to the Stars –⁠ Path to Developing a Healthy Gut Microbiota in Children: What Blocks It and What Helps?

The gut microbiota is acquired by an individual during the first 2 years of life. The main source is the mother’s microbiota. Obstacles to the formation of an adequate microbiota include…

21. 4. 2020 Source: GI, colic and microbiome

FOLFOXIRI and Panitumumab in mCRC Treatment –⁠ Improvement in Treatment Response and Metastasis Resectability

For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment, the FOLFOX (5-fluorouracil/leucovorin, oxaliplatin) or FOLFIRI (5-fluorouracil/leucovorin,…

21. 4. 2020 Source: Colorectal Cancer

Early Cytoreductive Treatment Delays Onset of Symptoms Associated with Metastatic Colorectal Carcinoma

Managing symptoms associated with advanced cancer has a significant impact on patients' quality of life and influences decisions about appropriate therapy for an individual patient. An international…

21. 4. 2020 Source: Colorectal Cancer

Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control

The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement in quality of life in a prospective multicenter observational study on patients with diabetes and…

21. 4. 2020 Source: Gastrointestinal Treatment

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Effect of Itopride on Esophageal Motility and Lower Esophageal Sphincter Function

Itopride is a prokinetic used in the therapy of functional non-ulcerous upper dyspeptic difficulties. The mechanism of action involves inhibition of acetylcholinesterase and antagonism at dopamine D2…

21. 4. 2020 Source: Gastrointestinal Treatment

Can tofacitinib have a positive impact on the mental stress of patients with rheumatoid arthritis?

In the population of patients with rheumatoid arthritis (RA), there is a higher incidence of depression and anxiety compared to the healthy population. These psychiatric comorbidities can lead to a…

21. 4. 2020 Source: Arthritis

Educational Quiz (For Downtime)

The following quiz has been prepared for you as an activity for relaxation and unwinding from today's hectic days. In an easy manner, it will refresh your knowledge about immune cells and may even offer...

20. 4. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Significant Reduction in the Extent and Intensity of Psoriasis After Initiating Therapy with Skin Foam −⁠ Case Study

A case study from the Clinic of Skin and Venereal Diseases, Faculty of Medicine, Palacky University, and University Hospital Olomouc, describes the treatment course of psoriasis in a young patient…

20. 4. 2020 Source: Topical Treatment of Psoriasis

Brodalumab –⁠ 5 Years of Data on Efficacy, Safety, and Quality of Life Improvement in Plaque Psoriasis

Chronic inflammatory diseases, including psoriasis, require therapeutic approaches that maintain efficacy and tolerability even during long-term treatment. One such modern modality is brodalumab, a…

20. 4. 2020 Source: Topical Treatment of Psoriasis

Impact of Candesartan on Achieving Remission in Patients with Active IgA Nephropathy

IgA nephropathy is the most common glomerulonephritis worldwide and in the Czech Republic. The effect of candesartan (an angiotensin receptor blocker) on the remission of active IgA nephropathy in…

18. 4. 2020 Source: Sartans in the Treatment of Hypertension

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