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News HPD 2024: Czech data from real-world practice confirm that mucolytic treatment can reduce COPD exacerbations, even in the future

Chronic obstructive pulmonary disease (COPD) is a global issue. Does it create the same burden everywhere? How does it contribute to premature deaths? How do women cope with COPD, and what significant problem does it pose for them? What factors contribute to it not being considered solely a smoker's disease? Why is it appropriate to add mucoactive agents when trying to eliminate COPD exacerbations? What emerged from early COPD screening conducted in the Czech Republic, and what do Czech real-world data show regarding the effectiveness of erdosteine in exacerbations? And what should be included in the proper diagnosis and treatment of this disease? All these topics were covered in a lecture by the head of the Pulmonary Clinic of the Medical Faculty of Charles University and University Hospital Hradec Králové, Associate Professor Vladimír Koblížek, M.D., Ph.D., during the XXVIII Hradec Pneumology Days held from April 24-26, 2024.

Source: Cough Therapy 24. 5. 2024

News MS in Children –⁠ An Overlooked Sister of Adult Diseases?

Multiple sclerosis is not just an adult disease. How common is it in children and how have current therapeutic possibilities advanced for this population both in our country and around the world?

Source: Multiple Sclerosis 6. 6. 2022

News Metamizole as an Analgesic with a Favorable Benefit-Risk Ratio

Metamizole is a well-established and widely used molecule in many countries worldwide, suitable as an alternative to opioids for patients with moderate to severe acute or chronic pain. The popularity of this drug is associated not only with its efficacy but also with its safety, with no contraindications for patients with cardiovascular, renal, or gastrointestinal comorbidities.

Source: Analgesia 29. 3. 2023

News Safety and Efficacy of Negative Pressure Therapy in Acute Infected Wounds

Negative Pressure Wound Therapy (NPWT) is a globally widespread wound care method. It involves creating a local negative pressure in the wound, with key benefits including moist wound healing in a closed environment, gradual reduction of wound volume by drawing in the edges, continuous drainage of exudate and tissue fluid, and promotion of granulation.

Source: Wound Healing 4. 5. 2020

Články časopisu Management of the adult buried penis

Author of the article: T. S. Hakky, J. Suber, A. Baumgarten, D. Smith, R. E. Carrion Source: Urologické listy | 1/2013 1. 3. 2013

Články časopisu Acquired angioedema with C1 inhibitor deficiency in a patient with low-grade B-lymphoma and the effect of underlying disease treatment on angioedema manifestations

Author of the article: M. Sobotková, J. Segethová Source: Transfuze a hematologie dnes | 3/2017 22. 11. 2017

News Venotonics in Hemorrhoid Therapy –⁠ Results of a Systematic Review

Hemorrhoids are among the most common pathological findings in the anorectal area, and their incidence increases with age. Various modalities are used in the treatment of this condition, which has unpleasant health and psychological complications, aiming to alleviate the symptoms. Widely used and very popular are so-called venotonics, a large group of drugs and dietary supplements, mostly of natural origin, including diosmin.

Source: Venous Insufficiency 27. 3. 2020

News Effectiveness of Tofacitinib in the Treatment of Ulcerative Colitis in Real-World Clinical Practice

One of the new modalities for the treatment of ulcerative colitis (UC) is tofacitinib. Its effectiveness has already been demonstrated in clinical studies and is now being proven in real-world clinical practice, where we can evaluate the results of patients who could not be included in clinical trials or those with refractory disease.

Source: Intestinal Inflammations 24. 11. 2022

News Physiological and Clinical Effect of Romiplostim in the Treatment of ITP

Romiplostim in the treatment of immune thrombocytopenia (ITP) has demonstrated safety and the promise of long-term remission, enabling many pediatric and adult patients to discontinue treatment and maintain a drug-free state.

Source: Immune Thrombocytopenia 11. 10. 2021

News Causes, Consequences, and Solutions to Weight Gain in Schizophrenia Treatment

The use of antipsychotics in the treatment of schizophrenia is often associated with the development of overweight and obesity, which poses a risk for the onset of many diseases and increases morbidity and mortality in these patients. Concern about weight gain is also a common reason for non-adherence to antipsychotic treatment. The cause of weight gain may also lie in the symptoms of the disease itself. We, therefore, provide a summary of the causes, consequences, and possible solutions to this undesirable impact of schizophrenia and its treatment.

Source: Modern Treatment of Schizophrenia 13. 3. 2024

News Off-label use of eye drops containing bromfenac in the treatment of cystoid macular edema in the only seeing eye of a complex patient –⁠ case report

The following case report discusses the effect of repeated use of an ophthalmic preparation containing bromfenac in a patient with recurrent cystoid macular edema (CME) in the only seeing eye with advanced glaucoma. The patient has undergone more than 15 eye surgeries or procedures, has been treated for glaucoma since 2005, and has multiple intolerances to eye drops and polymorphic problems, which she attributes to the application of the drops. The dominant personality trait is an anxious approach, which, together with the complicated findings in the only seeing eye, narrows the selection of therapeutic options.

Source: Treatment of Glaucoma 14. 6. 2024

News The Latest Updates of ESC Recommendations for Heart Failure Treatment

What is new in heart failure therapy? At the annual congress of the European Society of Cardiology (ESC), held from August 25–28, 2023 in Amsterdam, updates to clinical guidelines were traditionally presented. One of these was an update to the 2021 recommendations concerning the diagnosis and treatment of acute and chronic heart failure (HF). Below you will find a brief summary of the key changes.

Source: Heart Failure 18. 10. 2023

News Tiapride versus Haloperidol in the Therapy of Aggressiveness and Agitation in Elderly Patients with Cognitive Impairment

Acute restlessness, agitation, and aggression can be associated with psychiatric disorders but also be manifestations of somatic illnesses. Psychomotor agitation combined with disorientation is typical, for example, in older individuals with cognitive impairments. The primary goal of therapy is to calm the patient, most often using antipsychotics. The clinical study presented below compared the efficacy and safety of the antipsychotics haloperidol and tiapride versus placebo in patients with acute agitation and aggression who were diagnosed with mild to moderate cognitive impairment.

Source: Viral infections 19. 1. 2023

Články časopisu Fracture Liaison Service: pilot project in FH Královské Vinohrady

Author of the article: Kučerová Tereza, Suchoťko Vasyl, Malá Julia, Sotorník Richard, Švec Jan, Kirchhofová Kateřina, Skála-Rosenbaum Jiří, Brunerová Ludmila Source: Clinical Osteology | 1-2/2023 26. 4. 2023

Články časopisu Evolution of chronic lymphocytic leukemia treatment over the past 25 years

Author of the article: T. Papajík, R. Urbanová, P. Turcsányi Source: Transfuze a hematologie dnes | 1/2019 29. 3. 2019