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News Kadcyla in a New Indication –⁠ Adjuvant Therapy for Early HER2+ Breast Cancer

In December, the European Commission approved the expansion of the indication for Roche's medicinal product Kadcyla, which contains the active substance trastuzumab emtansine. This expansion makes adjuvant treatment accessible to a much larger number of patients with early HER2-positive breast cancer and reduces the likelihood of disease recurrence or progression.

Source: Breast Carcinoma 23. 1. 2020

News PID in children manifest differently, 10 warning signs help in diagnosis

We asked MUDr. Eva Hlaváčková from the Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, and St. Anne's University Hospital in Brno about the essential details regarding the 10 warning signs of primary immunodeficiencies (PID) and in which cases the vaccination schedule needs to be adapted for sick children.

Source: Primary and Secondary Immunodeficiencies 19. 4. 2021

News Full Compensation of Seizures as the Main Goal of Epilepsy Therapy: Will Patients Achieve It More Easily Than 20 Years Ago?

What is the relationship between the quality of life of patients and the degree of seizure compensation? Have the new antiepileptics (ASM) developed over the last decades improved the overall success rate of therapy?

Source: Epilepsy 28. 6. 2022

Články časopisu Fecal microbiota transplantation –⁠ past, present, and future

Author of the article: Stebel R., Vojtilová L., Husa P. Source: Gastroenterologie a hepatologie | 1/2020 25. 2. 2020

News Etiology and Therapy of Dry Eye Syndrome in a Nutshell

Dry eye syndrome, the most common diagnosis in outpatient ophthalmology practice, is a multifactorial disease with varying severity of symptoms. It reduces the quality of life and can also affect the patient's visual functions. Therapy is individualized according to the primary trigger of the disease and aims to restore the homeostasis of the ocular surface and tear film. Due to the rapid pace of modernization associated with numerous extrinsic factors contributing to the development of dry eye syndrome, its incidence is rising, as well as the number of topical therapeutic options.

Source: Ophthalmologic Diseases 15. 2. 2023

News Metformin −⁠ A Proven Helper That Effectively Protects the Heart of Diabetics

Metformin is one of the first-line medications for patients with type 2 diabetes. In addition to lowering blood glucose levels, it also affects other metabolic processes in the human body. Its antitumor, neuroprotective, and especially cardioprotective effects have been extensively studied, which can be advantageously utilized in the diabetic population.

Source: Modern Treatment of Diabetes 19. 10. 2020

News Even a Single Epileptic Seizure is Too Much

Focal epileptic seizures resistant to pharmacotherapy represent an ongoing unmet medical need.

Source: Epilepsy 7. 4. 2022

News Colours of Sepsis 2023: Antimicrobial Stewardship is a Necessity. The Spectrum of Effective Antimicrobial Modalities has Expanded to Include Another Combination

Inappropriate antibiotic (ATB) treatment is associated with high mortality, while unrestricted use of broad-spectrum antibiotics drives resistance development. Thus, the decision to deploy antibiotics becomes a choice between the current and future patient. Antimicrobial stewardship (AMS) is an essential strategy in daily operations. Extending the spectrum of antimicrobial agents is equally crucial in combatting resistant bacterial strains. A symposium on this theme was part of the expert program at this year's 'festival of intensive medicine' Colours of Sepsis, held in late January in Ostrava.

Source: Anti-Infectives 9. 2. 2023

News Prim. Václava Adámková: People mistakenly believe that there are enough antibiotics and that they will always handle infections

According to the World Health Organization (WHO), by 2050, infections untreatable with antibiotics could become the leading cause of death, surpassing cardiovascular and oncological diseases. Rising antimicrobial resistance was one of the main topics at the VIII Congress of Clinical Microbiology, Infectious Diseases, and Epidemiology (KMINE 2022), held in September in Prague. The topic was also the focus of the expert block ‘ATB stewardship,’ where epidemiologist Petr Smejkal, infectologist Aleš Chrdle, and microbiologist Václava Adámková discussed possible solutions to this global problem. We asked Adámková to summarize insights into the presented issues for us.

Source: Anti-Infectives 26. 10. 2022

News Invasive Pneumococcal Disease –⁠ Current Czech Data

The number of reported cases of invasive pneumococcal disease (IPD) returned to levels comparable to those before the COVID-19 pandemic in 2022. Regarding age-specific morbidity, the most at-risk groups are children under 1 year of age and seniors over 65 years old. The specific data for 2022 is provided by a report from the Center for Epidemiology and Microbiology of the National Institute of Public Health (SZÚ).

Source: Regular Vaccination 2. 10. 2023

Články časopisu Vitamin D and cardiovascular diseases

Author of the article: H. Matějovská Kubešová, B. Vepřeková, P. Weber, K. Bielaková, T. Gregorová Source: Kardiologická revue – Interní medicína | 1/2012 9. 3. 2012

News Trastuzumab Deruxtecan in Patients with HER2+ Metastatic Breast Cancer

Last year, results of studies published in the Lancet journal demonstrated a significant clinical benefit of trastuzumab deruxtecan in patients with HER2⁺ metastatic breast cancer (mBC) pre-treated with anti-HER2 therapy, in the 2nd or later lines of treatment compared to trastuzumab emtansine (DESTINY-Breast03 study, second interim overall survival analysis) and after failure of trastuzumab emtansine compared to physician's choice of therapy (DESTINY-Breast02 study).

Source: Ovarian and Breast Cancer 12. 3. 2024

News Treatment of Diabetes in Pregnancy with Metformin Does Not Increase the Risk of Low Birth Weight

In several studies, it has been observed that exposure to metformin during pregnancy, compared to insulin exposure, is associated with an increased relative risk of the newborn being small for gestational age. The authors of the presented cohort study aimed to clarify this risk in comparison to women with gestational diabetes who were not pharmacologically treated.

Source: Modern Treatment of Diabetes 21. 2. 2023

News Eletriptan as an effective and safe drug in acute migraine therapy

In the pharmacotherapy of acute migraine attacks, a pharmacologically diverse group of triptans is particularly used. The choice of the right antimigraine drug should be individualized, based on the intersection of the patient's nature of complaints and the pharmacological profile of the drug. The following text briefly summarizes the basic characteristics and profile of eletriptan.

Source: Treatment of Severe Migraine 20. 9. 2021

News Satisfaction of Patients Treated with Platinum Derivatives with Antiemetic Therapy

The fixed oral combination of netupitant with palonosetron (NEPA) is used for the prevention of nausea and vomiting induced by cytotoxic chemotherapy. A prospective German study evaluated the benefit of this therapy on the quality of life of patients treated with platinum derivatives.

Source: Antiemetic Therapy 23. 9. 2020