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News XR vs. IR Form of Metformin −⁠ It’s Not Just About Gastrointestinal Tolerability

It is well known that the XR form of metformin shows better gastrointestinal tolerability. However, research suggests that the two forms of metformin −⁠ XR and IR −⁠ differ in other aspects as well. In what ways? We will attempt to summarize this in the following text.

Source: Modern Treatment of Diabetes 16. 9. 2022

News Impact of Combined Oral Contraceptives on Body Weight

A relatively recent study investigated changes in the average body weight of women who used combined oral contraceptives with 30 μg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) or 30 μg EE and 2 mg chlormadinone acetate (CMA) for 6 months, comparing the results between the two groups.

Source: Oral Contraception 10. 4. 2022

Články časopisu Are risk factors in prenatal and perinatal period important for develompent of schizophrenia?

Author of the article: P. Ambroz, J. Janoutová, O. Machaczka, M. Kovalová, A. Pohlídalová, K. Vařechová, O. Košta, H. Tomášková, O. Šerý, L. Hosák, V. Janout Source: Česká gynekologie | 1/2017 20. 1. 2017

News Influence of ARNI on the Efficacy and Safety of Empagliflozin in the Treatment of Heart Failure with Reduced Ejection Fraction

Pharmacological inhibition of neprilysin and the AT1 receptor for angiotensin II (ARNI) through sacubitril/valsartan reduces cardiovascular (CV) mortality and the risk of hospitalization for heart failure. The same benefit has also been demonstrated with the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i), also known as gliflozins. A pre-specified sub-analysis of the EMPEROR-Reduced study evaluated whether the benefit of SGLT2i is also significant in patients treated with ARNI.

Source: Heart Failure 13. 7. 2022

News A Brief History of Deep Vein Thrombosis Treatment –⁠ From Antiquity to the Present

Deep vein thrombosis is among the common diseases that have accompanied humanity since its inception. Due to the low specificity of its clinical presentation (in contrast to, for example, varicose veins of the lower limbs), however, the disease long went undescribed in literature. The first descriptions of deep vein thrombosis did not appear until the Middle Ages –⁠ and from that moment, the gradual development of its treatment began. We offer you a brief but remarkable historical excursion in three stages.

Source: Prevention of Thrombosis in Surgery 4. 3. 2020

News Transfer of Microbiome from Mother to Child: A Key but Fragile Process

How does the transfer of gut microbiota between mother and child occur? Is this transfer clinically significant, and what factors can disrupt it? These questions are addressed in a 2019 review article by Dutch microbiologists.

Source: GI, colic and microbiome 25. 2. 2020

Články časopisu Quality, clinical effectivity and harmonisation of POCT

Author of the article: B. Friedecký, J. Kratochvíla Source: Klinická biochemie a metabolismus | 1/2019 1. 3. 2019

News How Does Myelodysplastic Syndrome Affect Patients' Quality of Life?

Myelodysplastic syndrome (MDS) is a heterogeneous group of disorders of hematopoietic stem cells with varying degrees of risk of progression to acute myeloid leukemia (AML). The therapeutic options for this disease are continually evolving. But what is the impact of this diagnosis on patients' quality of life?

Source: Myelodysplastic Syndrome (MDS) 15. 2. 2024

News Can the Use of Statins Help Reduce the Risk of Dementia?

A meta-analysis published last year by Taiwanese experts evaluated the connection between the use of statins and the incidence of dementia. What conclusions did the authors reach?

Source: Cardiovascular Risks 23. 3. 2021

News Doc. Jitka Fricová: The biggest challenge remains the patient with unbearable chronic pain

Research findings are pushing the boundaries of optimal chronic pain treatment, including better prevention and reduced side effects of analgesics. Algological care is readily accessible in the Czech Republic, yet it faces limitations, such as the less manageable nature of unbearable pain, particularly neuropathic or oncologic. We briefly discuss the topic with the head physician of the Pain Treatment Center at the Department of Anesthesiology, Resuscitation, and Intensive Care Medicine, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Doc. MUDr. Jitka Fricová, Ph.D.

Source: Analgesia 29. 3. 2023

News Diagnosis and Management of Interstitial Lung Processes Associated with Rheumatoid Arthritis

Interstitial lung processes (ILD) are common yet insufficiently diagnosed complications of rheumatoid arthritis (RA), significantly increasing the morbidity and mortality of patients. ILD can occur at any stage of RA, presenting a diverse clinical picture. Usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) are the most common findings on high-resolution CT (HRCT). Some patients with RA-associated ILD may exhibit a progressive phenotype characterized by expanding fibrotic changes on HRCT, declining lung function, worsening respiratory symptoms, and early mortality. A recently published review summarizes strategies for screening, monitoring, and managing ILD in RA.

Source: Progressive Interstitial Pulmonary Processes 3. 1. 2024

Články časopisu Anaesthesia for minor surgery in the early postpartum period –⁠ Czech and Slovak prospective national surveys

Author of the article: P. Tourač, J. Bláha, P. Nosková, R. Klozová, D. Seidlová, M. Grochová, M. Kosinová, Jiří Jarkovský, H. Zelinková, D. Schwarz, M. Svoboda, S. Richterová, O. Smékalová, B. Zaoralová, Z. Mrozek, Z. Krupková, L. Večeřa, H. Ivanková, A. Magyarová, J. Šimonová, J. Firment Source: Anesteziologie a intenzivní medicína | 2/2019 13. 5. 2019

News Role of Chemoimmunotherapy in the Era of Rapid Development of CLL Treatment Strategies and Emergence of New Drugs

In the context of the significant advancements in the field of immunotherapy and evidence of its efficacy in the treatment of chronic lymphocytic leukemia, it is pertinent to ask how this will influence therapeutic strategies in the context of first-line treatment and what the role of chemoimmunotherapy will be in the algorithms for CLL. At the 2019 NCCN Annual Congress, a panel of experts, led by Professors William G. Wierda from Texas MD Anderson Cancer Center and Jennifer R. Brown from Dana-Farber Cancer Institute, debated this topic.

Source: Chronic Lymphocytic Leukemia 22. 4. 2020

Články časopisu Prescription and dosage of RAAS inhibitors in patients with chronic heart failure in the FAR NHL registry

Author of the article: Monika Špinarová, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Karel Lábr, Ondřej Ludka, Jiří Jarkovský Source: Vnitřní lékařství | 1/2019 20. 2. 2019

News Teriflunomide under the microscope in studies and practice

Not always do the conclusions from clinical studies fully confirm in real clinical practice. Does this also apply to teriflunomide? Is its efficacy and safety consistent across age groups and individual studies?

Source: Multiple Sclerosis 3. 5. 2022