Search

News Pertuzumab significantly extends the life of patients with metastatic breast cancer

The final results of the CLEOPATRA clinical trial show that patients with HER2-positive metastatic breast cancer achieve 8-year overall survival of 37% with the targeted treatment combination of pertuzumab + trastuzumab + docetaxel.

Source: Breast Carcinoma 28. 4. 2020

News What Benefits Does the Fixed Combination of Candesartan/Amlodipine Bring?

A relatively new fixed combination used in the treatment of hypertension is represented by candesartan/amlodipine, that is, a sartan and a calcium channel blocker. Its advantage compared to the combination of ACE inhibitor/calcium channel blocker is primarily the lower occurrence of side effects.

Source: Sartans in the Treatment of Hypertension 9. 12. 2021

Články časopisu The INKA Program –⁠ “tailor-made” obstetric analgesia

Author of the article: A. Pařízek Source: Česká gynekologie | 3/2014 18. 6. 2014

News Enoxaparin in the Treatment of Pulmonary Embolism in a Morbidly Obese Patient –⁠ Case Report

The number of patients suffering from overweight and obesity has been steadily increasing in recent years. Obesity is one of the independent risk factors for thromboembolic disease. Treating thrombotic complications in obese patients poses a challenge not only because of the adjustments in anticoagulant dosing but also due to the lack of evidence regarding the safety and efficacy of higher doses of anticoagulants in this growing group of the population.

Source: Thromboprophylaxis 4. 4. 2022

News Can Thyroid Hormone Supplementation Reduce the Risk of Cognitive Disorders?

The recent systematic literature review presented below, published by authors from the California Institute of Behavioral Neurosciences and Psychology (CIBNP), focused, among other things, on potential associations between hypothyroidism and dementia and the impact of related therapeutic interventions in terms of improving cognitive functions.

Source: Thyroid Disorders 25. 10. 2022

News Treatment of HFrEF with Sacubitril/Valsartan Does Not Have to Be the ‘Last Resort’

The TRANSITION study has provided evidence on the safety and efficacy of administering sacubitril/valsartan to patients after acute decompensation of chronic heart failure with reduced ejection fraction of the left ventricle (HFrEF). A recent sub-analysis of its results suggested that not only patients with a long-known diagnosis but also those with newly diagnosed HFrEF could benefit from the treatment if the possibility of its prescription in this indication arises.

Source: Chronic Heart Failure and Lipidology 9. 3. 2020

News Experiences with Long-term Treatment of Psoriasis with Interleukin 17A Inhibitor

The current publication of the long-term extension of the UNCOVER-3 study, which focused on the treatment of psoriasis with ixekizumab, describes the efficacy and safety of 4 years of use of this drug.

Source: Biological Treatment 13. 4. 2021

News Do Beta-Blockers Increase the Risk of Hypoglycemia in Patients with Diabetes and Atherosclerosis?

Given that a large portion of patients with diabetes have proven cardiovascular disease, several clinical studies or their subsequent analyses address the effects of beta-blockers in these patients. One such analysis was the post-hoc analysis of the TECOS study, which among other things, attempted to evaluate the connection between the use of beta-blockers in type 2 diabetics with proven atherosclerotic cardiovascular disease and the incidence of hypoglycemic episodes.

Source: Cardiovascular Continuum 18. 5. 2020

Články časopisu Treatment of osteoarthritis

Author of the article: K. Pavelka Source: Česká revmatologie | 3/2012 30. 11. 2012

News Extension of Expected Lifetime When Treated with Empagliflozin in Patients with Type 2 Diabetes and Cardiovascular Disease

Reduction in expected lifetime is one of the main consequences of type 2 diabetes (T2DM). It is estimated that a 60-year-old patient with T2DM loses an average of 6–7 years of life compared to a person of the same age without T2DM. What impact does modern pharmacotherapy have on this adverse balance?

Source: Heart Failure 20. 8. 2021

News How to Choose the Ideal Venotonic or Vasoprotective –⁠ Which Properties Are Key?

Medicines and dietary supplements containing flavonoids, often hesperidin or diosmin, are available on the market. What should you consider when choosing these products?

Source: Venous Insufficiency 11. 2. 2020

Články časopisu Education in schizophrenia: How patients and their relatives assess the relapse prevention programme PREDUKA

Author of the article: Lucie Bankovská Motlová, Eva Dragomirecká, Šárka Matelová, Renata Otevřelová, Radka Čermáková, Jan Čermák, Eva Lednická, Renata Hegedüšová, Tomáš Hübsch, Soňa Rothanzlová, Martinatomešová, Filip Španiel, Eva Kitzlerová Source: Časopis lékařů českých | 1/2010 1. 1. 2010

News Perioperative Thromboprophylaxis in Elderly Patients

Thromboembolic disease (TED) is among the most common causes of death in hospitalized patients and also constitutes a significant portion of complications following surgical procedures. Without prophylaxis, thrombosis would develop in the perioperative period in almost 25% of patients. The risk of TED significantly increases with age, as does mortality. Over 21% of thrombotic complications occur in individuals over 65 years of age, and up to 16% of patients over 80 years old die shortly after being diagnosed with TED. It is crucial to focus on appropriate prevention and prophylaxis of TED in geriatric patients. However, studies have shown that thromboprophylaxis in hospitals in Europe and the USA is inadequate. Reasons may include concerns about increased bleeding during surgical procedures.

Source: Thromboprophylaxis 29. 4. 2021

News Screenings of Lung Cancer and COPD are Significant. What Do the Latest Data from Czechia Say?

At the end of January, an expert seminar was held, focusing on updates in the treatment of respiratory diseases. During this event, the head of the Pulmonary Clinic at LF UK and FN Hradec Králové, Associate Professor MUDr. Vladimír Koblížek, Ph.D., gave a lecture on the current Czech findings from lung cancer screenings and a project aimed at the early detection of chronic obstructive pulmonary disease (COPD).

Source: Cough Therapy 12. 4. 2023

News Pediatric Immune Thrombocytopenia Does Not Overlap with Adult ITP

Immune thrombocytopenia (ITP) is a highly heterogeneous disease characterized by various bleeding manifestations and different needs for treatment or likelihood of remission. The difference is accentuated in terms of the disease course between children and adult patients.

Source: Immune Thrombocytopenia 8. 6. 2020