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News After 20 years, a new treatment option for primary biliary cholangitis arrives

Primary biliary cholangitis (PBC), formerly known as cirrhosis, is a rare disease with a negative impact on prognosis and quality of life. While ursodeoxycholic acid (UDCA) has been essentially the only treatment option for PBC so far, in 2016, the European Medicines Agency (EMA) approved obeticholic acid as a second-line option. Since 2019, this medication has been available and fully covered by health insurance in 11 selected centers in the Czech Republic.

Source: Primary Biliary Cholangitis 10. 6. 2020

News Diabetic Cardiovascular Autonomic Neuropathy: How to Detect This Serious Diagnosis and Why Is It Dangerous?

Diabetic autonomic neuropathy can affect various organ systems. Cardiovascular autonomic neuropathy is one of its most severe forms with a significant impact on patient morbidity and mortality. How can it be detected in clinical practice?

Source: Diabetes 27. 1. 2022

News Expanded Vaccination Option Against Pneumococci Thanks to 15valent Vaccine

Our arsenal for preventing pneumococcal diseases has been expanded with a 15-valent conjugate vaccine that includes important serotypes causing invasive pneumococcal diseases (IPD). The following text briefly summarizes basic information not only about IPD, their prevention, diagnosis, and treatment, but especially about the management of vaccination with the 15-valent vaccine in practice.

Source: Regular Vaccination 20. 6. 2023

News Brentuximab Vedotin in Patients with R/R cHL in the Real World: What to Expect?

How does brentuximab vedotin (BV) perform as maintenance therapy in real-world practice for patients with relapsed or refractory classical Hodgkin lymphoma (R/R cHL) who have undergone autologous hematopoietic stem cell transplantation (HCT) and are at high risk of its failure? This question was posed by authors from King Abdullah International Medical Research Center at King Saud bin Abdulaziz University for Health Sciences in Riyadh. They presented their findings in a poster session at this year's virtual European Society for Blood and Marrow Transplantation (EBMT 2022) congress.

Source: Hematologic Malignancies 27. 4. 2022

News How do patients perceive the treatment of ITP with romiplostim?

Romiplostim, along with eltrombopag and avatrombopag, belongs to the group of thrombopoietin receptor agonists (TPO-RA) used in the second line of treatment for immune thrombocytopenia (ITP). Its efficacy and safety are confirmed by numerous studies, but how do patients perceive its use and to what extent does it improve their quality of life? This was the focus of a review article by authors from the American Baylor College of Medicine.

Source: Immune Thrombocytopenia 15. 4. 2024

News Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab

The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief overview.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 4. 3. 2024

News Alzheimer's Disease: Diagnosis Step by Step in 4 Points

Alzheimer's disease is the most common cause of dementia. With the aging population, this topic is becoming increasingly relevant. How have the knowledge and diagnostic possibilities of the disease progressed over the past decades?

Source: Cognitive in the treatment of Alzheimer's disease 16. 6. 2020

News Insufficiently Controlled Epilepsy Reduces Quality and Length of Life

The effects of uncontrolled epilepsy far exceed the moment of a seizure, having a substantial impact on the psychological and physical well-being of patients. These individuals often sustain injuries during seizures, leading to reduced mobility, a higher risk of associated diseases, and premature death.

Source: Epilepsy 7. 4. 2022

News Noonan Syndrome (Not Just) in the Pediatric Cardiologist's Office

Noonan Syndrome (NS) is a genetically determined disease associated with a high prevalence of (not just) congenital heart defects. When is it necessary to consider it in a cardiologist's office, where to refer the patient if suspected, and how to proceed if the diagnosis is confirmed?

Source: Growth Disorders 23. 2. 2021

Články časopisu Global Allergy and Asthma European Network (GA²LEN) addresses the epidemic of allergy and asthma

Author of the article: Petr Panzner, Petr Čáp, Peter Burney, Torsten Zuberbier, Paul Van Cauvenberg, Jean Bousquet Source: Časopis lékařů českých | 1/2010 1. 1. 2010

News You can confirm or exclude ATTRv amyloidosis through genetic testing

Source: Rare Diseases 16. 3. 2022

News Current Options and Prospects for Effective Antiemetic Treatment in an Effort to Increase Adherence of Oncological Patients to Chemotherapy

Chemotherapy-induced nausea and vomiting (CINV) is strongly associated with treatment in the minds of many oncology patients, and its occurrence is rated as one of the most dreaded and stressful complications. For most patients, adherence to recommendations for antiemetic prophylaxis can successfully prevent the occurrence of CINV. A review article published last year by an international team of authors in the journal Future Oncology provides an overview of the current spectrum of options in CINV prophylaxis, focusing on the first combined preparation in this indication, containing the active substances netupitant and palonosetron.

Source: Antiemetic Therapy 31. 3. 2020

Články časopisu Why do we still hesitate to accept the new international criteria for the diagnosis of gestational diabetes mellitus?
The current screening is non-uniform and does not correspondwith evidence-based medicine

Author of the article: Hana Krejčí, Kateřina Anderlová Source: Česká gynekologie | 3/2014 18. 6. 2014

News Multiparametric Magnetic Resonance in Predicting Progression of Low-Risk Prostate Cancer

A newly published study has demonstrated the utility of imaging using multiparametric magnetic resonance imaging (mpMRI) and its interpretation using PI-RADS version 2 (Prostate Imaging Reporting and Data System) in predicting unfavorable disease outcomes in patients with prostate cancer suitable for active surveillance.

Source: Prostate Health Index 4. 6. 2020

News Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy –⁠ Case Study

The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The patient developed an allergic reaction to low-molecular-weight heparin (LMWH) and was successfully managed with fondaparinux during pregnancy.

Source: Management of Thrombosis in Women 20. 5. 2021