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News Inhibition of Sclerostin in Osteoporosis Therapy

Romosozumab, a subcutaneously administered antibody against sclerostin, is one of the most potent osteoanabolics and appears to be a highly effective modality in the treatment of postmenopausal women's osteoporosis. Essential information about the mechanism of action, insights from completed pivotal studies, and practical recommendations for romosozumab treatment are summarized in the following brief overview.

Source: Osteoporosis – Trends in Sequential Therapy 27. 9. 2023

News Currently on the Issue of Interchangeability of Preparations with Levothyroxine in Practice

Levothyroxine (LT4) in oral form is the standard therapy for patients with hypothyroidism. Given the legislative possibility of generic substitution and the number of original and generic preparations containing LT4, its substitution is possible, though not recommended. What are the practical conclusions?

Source: Thyroid Disorders 17. 7. 2023

News Human Papillomavirus in Adults –⁠ HPV Does Not Choose Gender

A significant part of the population is exposed to human papillomaviruses (HPV) throughout their lives. In recent years, there has been a global effort to increase vaccination coverage not only among children and adolescents who have not yet been vaccinated but also among adult women and men who could benefit from it, including those who have likely already encountered HPV.

Source: Regular Vaccination 31. 5. 2024

News Treatment of Glaucoma: Without Preservatives for Everyone?

A comprehensive report by Professor John Thygesen from the University Hospital in Copenhagen analyzes patient groups for whom preservative-free antiglaucoma medications are particularly suitable. In conclusion, he suggests that if there are no price differences, widespread treatment with preservative-free preparations is preferable.

Source: Treatment of Glaucoma 20. 8. 2020

News When the Cause of Hematomas in Anticoagulated Patients is Not Anticoagulants –⁠ Case Report

Not every bleeding during anticoagulation, especially if within the therapeutic range, can be attributed to this treatment. Particularly in older individuals and the presence of typical extensive hematomas, it is necessary to consider another cause, such as acquired hemophilia A. The following case report illustrates how such a case can be detected and what can be done to improve the patient's prognosis.

Source: Acquired Hemophilia 18. 11. 2022

News Dabigatran vs. Warfarin: What and Why Do Patients Prefer?

The key to adherence to long-term anticoagulant therapy is primarily the satisfaction of patients with the set therapy. The RE-SONANCE study published in April 2021 compared patient satisfaction with anticoagulant treatment using the direct oral anticoagulant (DOAC) dabigatran versus vitamin K antagonists (VKAs). What were the findings?

Source: Anticoagulant Treatment 1. 7. 2021

News Spiolto Respimat System –⁠ Innovation for Easier Inhalation

Inhalation delivery is the most preferred method of drug administration in chronic obstructive pulmonary disease and bronchial asthma. The effectiveness of therapy is also conditioned by the correct inhalation technique. The aim of the following article is a brief comparison of inhalation systems, focusing on a new addition to the group of aerosol inhalers.

Source: COPD 16. 3. 2020

News Comparison of the Efficacy of Tofacitinib and Vedolizumab in the Treatment of Ulcerative Colitis After Anti-TNF Therapy Failure

Therapeutic options for ulcerative colitis resistant to anti-TNF-α antibody treatment are available, but there were no studies comparing the selective immunosuppressants tofacitinib and vedolizumab in this patient population. The aim of this comparison was a multicenter French study, the first results of which were presented at the 17th ECCO Congress 2022.

Source: Intestinal Inflammations 21. 8. 2022

News Innovative Form of Levothyroxine Ensures Accurate Dosing for Patients

In the treatment of hypothyroidism, precise dosing of replacement therapy is critical. An innovative formulation of levothyroxine has been developed to meet the updated, stricter standards of regulatory authorities, thereby ensuring the desired therapeutic effect.

Source: Thyroid Disorders 8. 6. 2022

News Results of Knee and Hip Joint Arthroplasty in Hemophiliacs

Total endoprosthesis implantation represents an effective solution for the terminal stages of joint degeneration in hemophiliacs. However, compared to the general population, this group of patients exhibits certain specificities, a higher rate of complications, and historically worse surgical outcomes. Recent studies show that with advancements in surgical techniques, implants, and perioperative care, the results are approaching those of the population without a history of bleeding disorders.

Source: Hemophilia with Movement 15. 3. 2022

News Cardiovascular System Affection in Children with Noonan Syndrome

Noonan syndrome is a genetically conditioned disease classified among the so-called RASopathies, caused by a germline mutation in the genes of the RAS/MAPK signaling pathway. Among other things, children with this disease typically present with cardiovascular system involvement.

Source: Growth Disorders 13. 12. 2021

News Recommendations for Lipid Administration in Patients on Home Parenteral Therapy

Home parenteral therapy is an important part of treatment for patients with chronic intestinal failure who cannot achieve adequate nutrition through enteral feeding. An integral component of this therapy is lipid emulsion, which provides a source of energy and essential fatty acids. However, long-term administration of lipid emulsion may be associated with liver damage. According to available studies, the risk can be reduced by adjusting the dosage of lipid emulsion and preferring emulsions without soybean oil.

Source: Parenteral Nutrition 4. 10. 2021

News DPP4 Inhibitors in Chronic Kidney Disease and Their Potential to Protect Against Diabetic Nephropathy

Preclinical and clinical observations suggest that dipeptidyl peptidase 4 (DPP4) inhibitors might offer additional benefits to patients apart from effective and safe glycemic control.

Source: Diabetes 14. 12. 2020

News Clinical Benefit of Mucolytics in the Treatment of Upper Respiratory Tract Infections

A new review based on published controlled and observational studies as well as real-world practice experiences demonstrates the benefits of ambroxol, bromhexine, carbocisteine, erdosteine, N-acetylcysteine, and sobrerol in the treatment of upper respiratory tract infections, including bronchitis, sinusitis, and rhinosinusitis.

Source: Cough Therapy 6. 2. 2020

News MUDr. Petr Majtan: Venofarmaka should receive at least partial coverage for hemorrhoidal disease −⁠ their benefit in this indication is clear

What is the use of venofarmaka before and after surgery for chronic venous disease (CVD), and what effects of this treatment does he observe in daily practice with his patients? We asked MUDr. Petr Majtan from the private surgical and proctological clinic DK Chirurgie in Prague 10.

Source: Venous Insufficiency 17. 12. 2023