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News Don't Hesitate to Refer a Patient to the MS Center: Time is Brain! Or What Recent Czech Research Has Shown?

Time is crucial for every disease, but it is doubly true for diseases of the nervous system! Why is it important to diagnose and treat multiple sclerosis (MS) early? How to do it? And how are we doing with speed here in the Czech Republic?

Source: Neurology - Multiple Sclerosis 17. 5. 2024

News Ocrelizumab in the Treatment of Multiple Sclerosis –⁠ 10-Year Data

Multiple sclerosis (MS) is a lifelong disease with a high risk of permanent disability. Current information on the long-term efficacy and safety of treatment is therefore absolutely essential for the optimal choice of therapeutic agent –⁠ in this case, ocrelizumab.

Source: Neurology - Multiple Sclerosis 20. 2. 2024

Články časopisu Clinical nutrition in surgery –⁠ ESPEN guideline with consensual voting of the working group of Society of Clinical Nutrition and Intensive Metabolic Care (SKVIMP

Author of the article: I. Satinský, E. Havel, K. Bezděk, I. Hanke, M. Káňová, P. Kohout, J. Maňák, V. Maňásek, J. Matek, F. Novák, I. Novák, M. Oliverius, J. Poledník, M. Šenkyřík, Z. Šerclová, P. Tešínský, L. Urbánek, Z. Zadák Source: Anesteziologie a intenzivní medicína | 2/2019 13. 5. 2019

News Fixed combination tramadol/paracetamol as an effective and safe option for long-term pain treatment even in polymorbid patients

Combined analgesics were historically recommended exclusively for the treatment of acute or postoperative pain, mainly due to the risk of individual components which, although potentiated their analgesic effect, also exhibited significant organ toxicity or led to long-term and difficult-to-resolve abuses. In recent years, however, fixed combinations containing fewer components have increasingly appeared on the market, and thanks to the optimal synergy of their effects, they can be used in smaller and safe doses. One such combination is tramadol with paracetamol, the place and possibilities of which in the treatment of chronic pain are discussed in the following text.

Source: Updates in Pain Treatment 1. 11. 2023

News Transthyretin –⁠ More Than a Thyroxine Transporter

Transthyretin (TTR) is an extracellular protein whose main role is to transport thyroxine and retinol in the body and brain. TTR tends to form amyloid deposits, which can lead to systemic disease known as TTR amyloidosis. Recently, it has been shown that this protein has a much wider spectrum of activities in the organism than previously thought.

Source: Amyloidosis 6. 2. 2023

News Diagnosis of von Willebrand Disease Step by Step

Von Willebrand disease (vWD) is the most common congenital bleeding disorder, with an estimated prevalence of 1/1000. It is classified into 3 types based on the form and extent of quantitative or qualitative deficiency. Diagnosis of vWD is a complex process that usually takes some time.

Source: Von Willebrand Disease 27. 4. 2021

News Revolutionary Change in the Paradigm of Multiple Sclerosis (MS) Treatment in the Czech Republic

At the beginning of last year, there was a revolutionary change in the paradigm of multiple sclerosis (MS) treatment in the Czech Republic. Patients with MS and an unfavorable prognosis no longer have to go through ineffective medications on their way to highly effective therapy (HET, High Efficacy Therapy), but can be treated with the highly effective drug Ocrevus® from the first symptoms of the disease.

Source: Neurology - Multiple Sclerosis 11. 9. 2023

News Principle of Slowed Wound Healing Due to Stress Revealed

There is no doubt that psychological stress significantly slows down the process of healing wounds. The principle of how this phenomenon occurs, however, has remained unexplained. Swiss scientists focused on macrophages. Their function is to remove pathogens from the healing wound.

Source: Wound Healing 28. 4. 2020

Články časopisu Diabetes mellitus and heart failure: the role of SGLT2 inhibitors

Author of the article: Jindřich Špinar, Jiří Vítovec, Lenka Špinarová Source: Athero Review | 1/2018 7. 3. 2018

News Etiology of Recurrent Reproductive Losses –⁠ Focus on Genetics

Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The etiology of up to half of these cases remains unexplained, and recurrent reproductive losses are considered a complex disease. We provide a brief overview of the current knowledge on their possible etiology and genetic correlations, both on the part of the mother and father.

Source: Genetics 4. 5. 2023

Články časopisu BENIGN DERMATOSIS OF PENIS

Author of the article: MUDr. David Němec Source: Urologické listy | 4/2005 4. 1. 2006

Články časopisu Comorbidity of Migraine and Depression –⁠ a Meta-analysis

Author of the article: J. Kožený, C. Höschl, L. Tišanská Source: Česká a slovenská neurologie a neurochirurgie | 6/2013 13. 11. 2013

News Updated Recommendations of the European Society of Cardiology for the Treatment of HCM

Newly published guidelines by the European Society of Cardiology (ESC) bring several updates in the care of patients with cardiomyopathies. In the following excerpt, we focus on new recommendations for the pharmacotherapy of hypertrophic cardiomyopathy (HCM) in the case of left ventricular outflow tract obstruction (LVOTO).

Source: Hypertrophic Cardiomyopathy (HCM) 28. 4. 2024

News Incontinence Dermatitis -⁠ Common, Yet Often Overlooked Diagnosis

Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.

Source: Incontinence 21. 4. 2020

News Empagliflozin Secures Reimbursement for Heart Failure Treatment

Starting May 1st, health insurance companies will cover Jardiance^® (empagliflozin) for patients with heart failure with reduced ejection fraction. Cardiologists, pediatric cardiologists, angiologists, and internists will be able to prescribe it with reimbursement. This decision was made by the State Institute for Drug Control (SÚKL) in mid-April. Hundreds of thousands of Czechs suffering from this serious condition will now have access to another effective medication. The drug is manufactured by Boehringer Ingelheim.

Source: Heart Failure 3. 5. 2022