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News Revolutionary Change in the Paradigm of Multiple Sclerosis (MS) Treatment in the Czech Republic

At the beginning of last year, there was a revolutionary change in the paradigm of multiple sclerosis (MS) treatment in the Czech Republic. Patients with MS and an unfavorable prognosis no longer have to go through ineffective medications on their way to highly effective therapy (HET, High Efficacy Therapy), but can be treated with the highly effective drug Ocrevus® from the first symptoms of the disease.

Source: Neurology - Multiple Sclerosis 11. 9. 2023

News Principle of Slowed Wound Healing Due to Stress Revealed

There is no doubt that psychological stress significantly slows down the process of healing wounds. The principle of how this phenomenon occurs, however, has remained unexplained. Swiss scientists focused on macrophages. Their function is to remove pathogens from the healing wound.

Source: Wound Healing 28. 4. 2020

Články časopisu Diabetes mellitus and heart failure: the role of SGLT2 inhibitors

Author of the article: Jindřich Špinar, Jiří Vítovec, Lenka Špinarová Source: Athero Review | 1/2018 7. 3. 2018

News Etiology of Recurrent Reproductive Losses –⁠ Focus on Genetics

Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The etiology of up to half of these cases remains unexplained, and recurrent reproductive losses are considered a complex disease. We provide a brief overview of the current knowledge on their possible etiology and genetic correlations, both on the part of the mother and father.

Source: Genetics 4. 5. 2023

Články časopisu Comorbidity of Migraine and Depression –⁠ a Meta-analysis

Author of the article: J. Kožený, C. Höschl, L. Tišanská Source: Česká a slovenská neurologie a neurochirurgie | 6/2013 13. 11. 2013

News Updated Recommendations of the European Society of Cardiology for the Treatment of HCM

Newly published guidelines by the European Society of Cardiology (ESC) bring several updates in the care of patients with cardiomyopathies. In the following excerpt, we focus on new recommendations for the pharmacotherapy of hypertrophic cardiomyopathy (HCM) in the case of left ventricular outflow tract obstruction (LVOTO).

Source: Hypertrophic Cardiomyopathy (HCM) 28. 4. 2024

News Incontinence Dermatitis -⁠ Common, Yet Often Overlooked Diagnosis

Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.

Source: Incontinence 21. 4. 2020

News Empagliflozin Secures Reimbursement for Heart Failure Treatment

Starting May 1st, health insurance companies will cover Jardiance^® (empagliflozin) for patients with heart failure with reduced ejection fraction. Cardiologists, pediatric cardiologists, angiologists, and internists will be able to prescribe it with reimbursement. This decision was made by the State Institute for Drug Control (SÚKL) in mid-April. Hundreds of thousands of Czechs suffering from this serious condition will now have access to another effective medication. The drug is manufactured by Boehringer Ingelheim.

Source: Heart Failure 3. 5. 2022

News Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia

Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the potential of its multimodal effect sometimes remains untapped.

Source: Depression and Anxiety 19. 7. 2020

News Alopecia Areata –⁠ Autoimmune Inflammatory Disease and a New Targeted Treatment Option

Alopecia areata (AA) is one of the non-scarring focal alopecias. It is an autoimmune disease of the hair follicle, the etiopathogenesis of which is not entirely understood. At the hair root, a lymphocytic inflammatory infiltrate develops, resulting in follicle miniaturization and the growth of a thin dystrophic hair. Recently, however, a new strategy for the treatment of AA has emerged, focusing on reducing inflammation of the hair follicle by inhibiting Janus kinases (JAK). This is the first therapeutic modality officially approved for this indication.

Source: Biological Treatment 31. 10. 2022

Články časopisu Type 1 and 2 diabetes and pregnancy

Author of the article: L. Féderová, M. Korbeľ, Z. Nižňanská Source: Praktická gynekologie | 2/2010 23. 7. 2010

Články časopisu ALTERNATIVE PROCEDURE FOR COMPLETE DENTURE FABRICATION

Author of the article: R. Mounajjed, M. Přibyl Source: Česká stomatologie / Praktické zubní lékařství | 2/2019 24. 6. 2019

Články časopisu Guidelines of the Czech Society of Hepatology for diagnosis and treatment of primary biliary cholangitis

Author of the article: T. Fejfar, T. Vaňásek, P. Hůlek, L. Vítek, S. Fraňková, R. Brůha Source: Gastroenterologie a hepatologie | 2/2018 4. 5. 2018

News Efficacy and Safety of Dual Bronchodilator Therapy for COPD –⁠ From Randomized Clinical Trials to Real-World Clinical Practice

Dual bronchodilator therapy (LAMA + LABA) represents one of the mainstays of treating chronic obstructive pulmonary disease (COPD). The aim of the recent systematic review presented below was to assess the efficacy and safety of this dual therapy compared to monotherapy or other combinations in the context of clinical trials and real-world clinical practice.

Source: Treatment of Asthma and COPD 18. 11. 2021

News Diagnosis of Cow Milk Protein Allergy −⁠ Current Methods and Their Diagnostic Value

Cow milk protein allergy (CMPA) is among the most common pediatric food allergies. In case of early reaction, the child should be immediately referred to an allergist; for delayed symptoms, an elimination-exposure test can be performed under the guidance of a pediatrician.

Source: GI, colic and microbiome 15. 2. 2023