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News Therapy of Chronic Leg Ulcers According to Evidence-Based Medicine

Chronic ulcers on the lower extremities are defined as trophic defects that show no signs of healing after 3 months of appropriate treatment or are not healed even after 12 months of treatment. Their incidence and prevalence are continuously increasing, and they currently represent not only a serious medical problem but also a socioeconomic issue. An overview article published by German physicians focuses on summarizing the therapy of leg ulcers according to the principles of evidence-based medicine.

Source: Wound Healing 15. 11. 2020

News Nutritional Therapy for Critically Ill Patients in the ICU –⁠ Current Recommendations

Critically ill patients hospitalized in the intensive care unit (ICU) require nutritional support to maintain adequate energy intake. Only by doing so can their clinical condition be prevented from worsening. Therefore, we summarize the current recommendations regarding nutritional therapy as part of care in the ICU in the following text.

Source: Parenteral Nutrition 4. 10. 2021

News Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia

The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.

Source: Neuropathic Pain 22. 6. 2020

News Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin

Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be expected to alleviate painful symptoms and improve sleep quality, thereby significantly enhancing patients' quality of life.

Source: Neuropathic Pain 21. 5. 2021

News The Brain, Too, Has Its Midlife Crisis. How Do These Changes Relate to the Risk of Dementia in Old Age?

The human brain undergoes rapid changes during certain developmental periods. Childhood, adolescence, and advanced old age undoubtedly belong to these. For much of adulthood, it seems that nothing much actually happens. However, it turns out that the brain’s clock begins to accelerate around 40–50 years of age. What impact do these gradual changes have on our future health?

Source: 31. 10. 2024

News Why Do People Lose Weight Differently on GLP-1RA? The NBEA Gene Was Investigated

Glucagon-like peptide-1 receptor agonists (GLP-1RA) show promising anti-obesity effects, but their efficacy varies among individuals. A newly published study examined the role of the NBEA (neurobeachin) gene in weight loss while using these drugs, analyzing two large cohorts of real-world patients.

Source: 13. 8. 2025

News Pregabalin in Seniors Confirmed Its Safety and Effectiveness

A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in the general population sample?

Source: Neuropathic Pain 25. 6. 2020

News Overview of Current Treatment Options for MRSA-Induced Pneumonia

Pneumonia caused by methicillin-resistant strains of Staphylococcus aureus (MRSA) remains a disease with high mortality requiring urgent treatment, whether it is a community-acquired or nosocomial infection. Italian authors published a review article at the beginning of 2022, describing the current available treatment modalities for this infection based on a literature survey.

Source: Anti-Infectives 8. 7. 2022

Články časopisu Predictors of combined hormone contraception choice between Czech and Slovak women

Author of the article: Tomáš Fait Source: Česká gynekologie | 3/2011 11. 7. 2011

News Efficacy and Safety of Fenfluramine in the Treatment of Lennox-Gastaut Syndrome –⁠ An Overview of Current Knowledge

In a recently published article, British authors summarize the current knowledge on the efficacy and safety of fenfluramine (FFA) in the treatment of Lennox-Gastaut syndrome (LGS, a developmental and epileptic encephalopathy). In addition to the reduction in seizure frequency demonstrated in clinical studies, they discuss the impact of fenfluramine on reducing the risk of sudden unexpected death in epilepsy (SUDEP), improving cognitive function in patients, and its safety concerning weight loss and heart disorders.

Source: Rare Diseases in Neurology 21. 6. 2024

News TTR amyloidosis –⁠ at the crossroads of cardiology and orthopedics

In wild-type transthyretin amyloid cardiomyopathy, extra-cardiac symptoms occur in addition to cardiac symptoms. Common and characteristic orthopedic manifestations include bilateral carpal tunnel syndrome, spinal canal stenosis in the lumbar region, or atraumatic rupture of the m. biceps brachii tendon. These extra-cardiac symptoms often precede the actual heart involvement. Recognizing them can thus increase diagnostic suspicion for cardiac amyloidosis and help in the timely establishment of the correct diagnosis and initiation of specific treatment. For example, even a rheumatologist or orthopedist can direct an elderly patient with an otherwise unexplained constellation of musculoskeletal symptoms to cardiology examination early, thereby significantly improving the patient's prognosis.

Source: Amyloidosis 14. 6. 2023

News Wireless Smart Devices Monitor Health by Detecting Sounds

The human body continuously emits various forms of acoustic-mechanical signals that can provide important information about its health. Researchers from Northwestern University in the USA have developed miniature wearable devices (wearables) capable of simultaneously detecting sounds from multiple locations on the body, thereby continuously monitoring the health of the wearer. In a pilot project, the devices were tested on prematurely born infants with breathing and intestinal motility disorders and on adults with chronic lung diseases.

Source: 2. 4. 2024

News Tiapride versus Haloperidol in the Therapy of Aggressiveness and Agitation in Elderly Patients with Cognitive Impairment

Acute restlessness, agitation, and aggression can be associated with psychiatric disorders but also be manifestations of somatic illnesses. Psychomotor agitation combined with disorientation is typical, for example, in older individuals with cognitive impairments. The primary goal of therapy is to calm the patient, most often using antipsychotics. The clinical study presented below compared the efficacy and safety of the antipsychotics haloperidol and tiapride versus placebo in patients with acute agitation and aggression who were diagnosed with mild to moderate cognitive impairment.

Source: Viral infections 19. 1. 2023

Články časopisu Has everything really been discovered about SGLT2 inhibitors?

Author of the article: Daša Skripová Source: Diabetes a obezita | 38/2019 8. 2. 2020

News Efficacy and Safety of Dupilumab in the Treatment of Severe Asthma Insufficiently Controlled by Standard Therapy –⁠ Current Clinical Practice Data

If severe bronchial asthma with type 2 inflammation is insufficiently controlled by combined maintenance therapy, dupilumab –⁠ a recombinant monoclonal antibody inhibiting the signaling pathway of interleukins 4 and 13 –⁠ can be added. What is its efficacy in clinical practice? We summarize findings from 3 recent retrospective studies.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 16. 3. 2023