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News Pregabalin in Seniors Confirmed Its Safety and Effectiveness

A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in the general population sample?

Source: Neuropathic Pain 25. 6. 2020

News Overview of Current Treatment Options for MRSA-Induced Pneumonia

Pneumonia caused by methicillin-resistant strains of Staphylococcus aureus (MRSA) remains a disease with high mortality requiring urgent treatment, whether it is a community-acquired or nosocomial infection. Italian authors published a review article at the beginning of 2022, describing the current available treatment modalities for this infection based on a literature survey.

Source: Anti-Infectives 8. 7. 2022

Články časopisu Predictors of combined hormone contraception choice between Czech and Slovak women

Author of the article: Tomáš Fait Source: Česká gynekologie | 3/2011 11. 7. 2011

News Efficacy and Safety of Fenfluramine in the Treatment of Lennox-Gastaut Syndrome –⁠ An Overview of Current Knowledge

In a recently published article, British authors summarize the current knowledge on the efficacy and safety of fenfluramine (FFA) in the treatment of Lennox-Gastaut syndrome (LGS, a developmental and epileptic encephalopathy). In addition to the reduction in seizure frequency demonstrated in clinical studies, they discuss the impact of fenfluramine on reducing the risk of sudden unexpected death in epilepsy (SUDEP), improving cognitive function in patients, and its safety concerning weight loss and heart disorders.

Source: Rare Diseases in Neurology 21. 6. 2024

News TTR amyloidosis –⁠ at the crossroads of cardiology and orthopedics

In wild-type transthyretin amyloid cardiomyopathy, extra-cardiac symptoms occur in addition to cardiac symptoms. Common and characteristic orthopedic manifestations include bilateral carpal tunnel syndrome, spinal canal stenosis in the lumbar region, or atraumatic rupture of the m. biceps brachii tendon. These extra-cardiac symptoms often precede the actual heart involvement. Recognizing them can thus increase diagnostic suspicion for cardiac amyloidosis and help in the timely establishment of the correct diagnosis and initiation of specific treatment. For example, even a rheumatologist or orthopedist can direct an elderly patient with an otherwise unexplained constellation of musculoskeletal symptoms to cardiology examination early, thereby significantly improving the patient's prognosis.

Source: Amyloidosis 14. 6. 2023

News Wireless Smart Devices Monitor Health by Detecting Sounds

The human body continuously emits various forms of acoustic-mechanical signals that can provide important information about its health. Researchers from Northwestern University in the USA have developed miniature wearable devices (wearables) capable of simultaneously detecting sounds from multiple locations on the body, thereby continuously monitoring the health of the wearer. In a pilot project, the devices were tested on prematurely born infants with breathing and intestinal motility disorders and on adults with chronic lung diseases.

Source: 2. 4. 2024

News Tiapride versus Haloperidol in the Therapy of Aggressiveness and Agitation in Elderly Patients with Cognitive Impairment

Acute restlessness, agitation, and aggression can be associated with psychiatric disorders but also be manifestations of somatic illnesses. Psychomotor agitation combined with disorientation is typical, for example, in older individuals with cognitive impairments. The primary goal of therapy is to calm the patient, most often using antipsychotics. The clinical study presented below compared the efficacy and safety of the antipsychotics haloperidol and tiapride versus placebo in patients with acute agitation and aggression who were diagnosed with mild to moderate cognitive impairment.

Source: Viral infections 19. 1. 2023

Články časopisu Has everything really been discovered about SGLT2 inhibitors?

Author of the article: Daša Skripová Source: Diabetes a obezita | 38/2019 8. 2. 2020

News Efficacy and Safety of Dupilumab in the Treatment of Severe Asthma Insufficiently Controlled by Standard Therapy –⁠ Current Clinical Practice Data

If severe bronchial asthma with type 2 inflammation is insufficiently controlled by combined maintenance therapy, dupilumab –⁠ a recombinant monoclonal antibody inhibiting the signaling pathway of interleukins 4 and 13 –⁠ can be added. What is its efficacy in clinical practice? We summarize findings from 3 recent retrospective studies.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 16. 3. 2023

News Limits of Glycated Hemoglobin and the Importance of Other Glycated Proteins

Glycated hemoglobin is a gold standard in the diagnosis and management of diabetes treatment. However, its disadvantages include numerous factors that can cause false increases or decreases in its levels. Therefore, the scientific community is also interested in researching other glycated proteins that could be used in diabetes control. So, what should we keep in mind when collecting glycated hemoglobin?

Source: Modern Treatment of Diabetes 17. 2. 2022

News Memantine Eases Daily Life for Patients and Caregivers

What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?

Source: Cognitive in the treatment of Alzheimer's disease 12. 10. 2020

News Summary of Czech Recommendations for the Diagnosis and Treatment of Schizophrenia in Children and Adolescents 2022

In June 2022, the Psychiatric Society of the Czech Medical Association JEP updated its recommendations for the diagnosis and treatment of schizophrenia in children and adolescents. This is the first online version, which will allow for faster implementation of new findings important for clinical practice and decision-making by state institutions. We bring you a summary of the key points of these recommendations.

Source: Modern Treatment of Schizophrenia 21. 2. 2023

News Bacterial Biofilm as a Complication of Respiratory Disease Treatment

One of the unique characteristics of certain microorganisms is their ability to form organized communities enveloped in extracellular polymeric matrix and firmly attached to a solid surface or interphase or forming aggregates, collectively referred to as biofilm. Clinically, the major issue is the formation of pathogenic and conditionally pathogenic organisms' biofilm on tissues (such as respiratory tracts) or the surfaces of various medical devices (including catheters and implants), as it represents a dangerous complication leading to the development of chronic, recurrent, and scarcely treatable conditions.

Source: Cough Therapy 28. 11. 2023

News Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?

The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of heart failure with preserved ejection fraction of the left ventricle (HFpEF). Recent studies in this heterogeneous disease suggest the importance of carefully determining the HFpEF phenotype in a given patient based on pathophysiology, which enables better individualization of treatment. The authors also reflect on the success of gliflozins in treating HFpEF and how HFpEF pharmacotherapy can be further improved.

Source: Heart Failure 4. 3. 2024

News Bimekizumab in 3rd Line Biological Treatment After Risankizumab Failure –⁠ Case Study

The possibilities of biological therapy for severe forms of psoriasis are very broad today. Achieving remission or reducing disease activity by 90-100% from the baseline state (PASI 90-100) is highly probable, especially when using biological drugs from the IL-17 or IL-23 inhibitor groups. However, individually, patients may exhibit primary or secondary resistance even when using these preparations, necessitating a change in biological treatment. The following case study presents the case of a young man who achieved complete disease remission with bimekizumab after the previous failure of ixekizumab and risankizumab.

Source: Psoriasis 22. 3. 2024