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News Current Recommendations of the International League Against Epilepsy for the Treatment of Seizures in Newborns

In 2023, a team of experts in neurology, neonatology, and pediatrics, along with representatives of parents, published recommendations for the treatment of epileptic seizures in newborns. These were developed based on a systematic literature review (and in cases of insufficient evidence, based on consensus achieved using the Delphi method) and include first and second choice pharmacotherapy, dosing, duration of treatment, effects of therapeutic hypothermia, and the use of pyridoxine. We offer their summary in a nutshell (and always indicate the strength of the recommendation in parentheses).

Source: Quick aid for acute convulsive seizures in children and adolescents 21. 5. 2024

Články časopisu Vascular age

Author of the article: Ondřej Petrák, Richard Češka Source: Vnitřní lékařství | 12/2019 19. 1. 2020

News Can AI Help Accelerate the Development of Antibiotics for Gonorrhea and MRSA?

The overuse of antibiotics has helped bacteria become resistant to them. In the fight against antibiotic resistance, the involvement of artificial intelligence in the development of new drugs could prove beneficial. Using AI, experts from MIT examined more than 36 million possible compounds and evaluated their antimicrobial properties. The researchers also analyzed potential new compounds that had not yet been synthesized. The best candidate molecules discovered are structurally distinct from all existing antibiotics and appear to disrupt bacterial cell membranes through previously unobserved mechanisms.

Source: 2. 1. 2026

News H₂FPEF Score for Estimating the Probability of Heart Failure with Preserved Ejection Fraction in Persons with Unexplained Dyspnea

The simple, validated H₂FPEF scoring system based on clinical and echocardiographic parameters, developed by experts from the Mayo Clinic, allows the differentiation of heart failure with preserved ejection fraction (HFpEF) from dyspnea of other etiologies and helps decide whether further examinations are necessary. The score can be calculated online and in the Czech language.

Source: Heart Failure 23. 3. 2023

News State of the Intestinal Microbiome and COVID-19 Infection −⁠ Possible Correlations

Some patients infected with the SARS-CoV-2 virus exhibit gastrointestinal symptoms, including diarrhea, during the course of COVID-19. Current knowledge suggests that COVID-19 symptoms are related, among other things, to the intestinal microbiome. Could the use of probiotics therefore act as a prevention of this disease or its more severe course?

Source: GI, colic and microbiome 16. 2. 2021

News Comorbidities of Migraine and Their Impact on Pain Frequency and Intensity

The MAST study, published in March of this year in the prestigious The Journal of Headache and Pain, focused on the occurrence of associated diseases in patients with migraine. What is the prevalence of individual comorbidities and which of them are associated with changes in pain intensity and frequency?

Source: Migraine 27. 7. 2020

News X-ray in Dentistry: Who Can Indicate and Who Can Perform?

X-ray is an integral and important part of dental diagnostics. However, since it is also a source of ionizing radiation, its use is subject to legislative regulations that govern it.

Source: Dental Care 4. 6. 2024

Články časopisu Bone cement implantation syndrome

Author of the article: Filip Čechlovský Source: Úrazová chirurgie | 2/2017 17. 5. 2018

News When to Suspect Dravet Syndrome?

In 2022, an international consensus panel of experts on the diagnosis and treatment of Dravet syndrome was published. This was created due to the recently approved specific treatments for this disease and the development of disease-modifying therapies. The goal of the consensus is to improve diagnosis, set therapeutic goals, and optimal treatment procedures. We summarize the symptoms of the disease and situations in which genetic testing of the causal mutation is appropriate.

Source: Rare Diseases in Neurology 29. 6. 2023

News Initial Treatment for Newly Diagnosed ITP Patients at a Glance

The revised international consensus on the management of primary immune thrombocytopenia (ITP) from 2019 outlines several points summarizing suitable initial treatment for newly diagnosed individuals with ITP.

Source: Immune Thrombocytopenia 21. 2. 2023

News Index of Prostate Health as a Predictive Biomarker of Biopsy Outcome

As demonstrated by Spanish authors in their work published at the beginning of 2018, the Prostate Health Index (PHI) is a biomarker that can refine the prediction of prostate biopsy outcomes in men with elevated prostate-specific antigen (PSA) levels.

Source: Prostate Health Index 2. 4. 2020

News Tapentadol Hydrochloride in Clinical Practice –⁠ To Whom, When, How, and Why?

Thanks to its specific properties, tapentadol hydrochloride ranks among the most effective opioids for managing chronic non-cancer pain. Unlike most opioids, it also exhibits an analgesic effect in neuropathic pain. The following brief overview summarizes its mechanism of action and resulting benefits, reimbursement and prescription conditions, its place in the pain management algorithm, and examples of its application in clinical practice.

Source: Updates in Pain Treatment 12. 10. 2023

News Discontinuation of Methotrexate After Initiation of Tofacitinib in the Treatment of Rheumatoid Arthritis

New real-world data show that in patients with rheumatoid arthritis (RA) who started treatment with tofacitinib combined with oral methotrexate (MTX), it is possible to discontinue MTX and achieve the same treatment results as with its continued use, additionally at lower costs.

Source: Arthritis 27. 7. 2022

News Position of Levodropropizine in Cough Therapy

An international group of specialists focused in 2016–2017 on a detailed evaluation of current options for cough therapy. The authors based their analysis on individually prepared reviews using Medline and Embase databases, and they presented their work's results last year in the journal Pulmonary Pharmacology & Therapeutics.

Source: Cough Therapy 15. 1. 2020

News Deficit dihydropyrimidine dehydrogenase and its association with 5-fluorouracil toxicity

Deficit dihydropyrimidine dehydrogenase (DPD) is a risk factor for severe toxicity of 5-fluorouracil (5-FU). Below, we summarize current knowledge regarding the identification of patients with pathogenic variants of the DPYD gene and study results concerning the safety of therapy with respect to dose individualization based on genotyping.

Source: Genetics 12. 6. 2023