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News Epstein-Barr Virus –⁠ Is the Culprit of MS Revealed?

Could the Epstein-Barr virus hold the answer to the etiology of multiple sclerosis? A dataset of over 10 million American recruits offered intriguing insights. You may have encountered the conclusions of one of the most extensive studies in modern history in the media. Let's take a closer look at the work of Kjetil Bjornevik and his colleagues.

Source: Multiple Sclerosis 23. 5. 2022

News Reimbursement vs. Indication: Are They Clashing in Alzheimer's Disease?

Data from clinical trials and recommended procedures do not always align with insurance reimbursement criteria. Is this the case with Alzheimer's disease treatment?

Source: Cognitive in the treatment of Alzheimer's disease 17. 5. 2020

News Key for Patients with PBC are Timely Diagnosis and Assessment of Therapy Effectiveness

Primary biliary cholangitis (PBC) cannot be cured. It progresses slowly and over several decades leads to liver cirrhosis with all its potential consequences, including possible transplantation and the risk of premature death. The foundation of PBC pharmacotherapy is ursodeoxycholic acid (UDCA) and in recent years, obeticholic acid (OCA) has also been available, which European and Czech guidelines recommend as the second-line treatment. One of the symposiums at this year's XLVIII May Hepatology Days also focused on PBC and its therapy, including experiences from Czech practice.

Source: Primary Biliary Cholangitis 19. 7. 2021

News Metformin in Pregnancy and Its Safety Profile

In Finland, a comprehensive analysis of data from the national registry was conducted to assess whether exposure to metformin during intrauterine development is associated with an increased risk of long-term or short-term health problems.

Source: Modern Treatment of Diabetes 6. 6. 2022

News Urinary Incontinence in Old Age as the Most Frequent Medical Problem

In patients over 65 years of age, incontinence occurs more frequently than cancer or cardiovascular diseases. Urine leakage significantly reduces the quality of life for seniors, worsens their overall health, and isolates them from society. Therefore, doctors should participate in destigmatizing this problem and actively offer their help to seniors and their family members.

Source: Incontinence 9. 9. 2020

News Thanks to Buccolam, the reality of suppressing convulsive seizures in children and adolescents approaches parents' ideal management

What crosses the mind of a parent when they notice their epileptic child or adolescent is having a convulsive seizure? They want it to be over quickly and safely. What constitutes the integral part that makes this wish a reality? And how does the newest treatment modality, buccally administered midazolam (Buccolam), address these needs?

Source: Quick aid for acute convulsive seizures in children and adolescents 25. 10. 2023

News Prediction of Hypocalcemia Risk in Patients Treated with Denosumab and Active Form of Vitamin D

According to new work by Japanese authors, it appears that the risk factors for the development of hypocalcemia in patients treated with denosumab and calcitriol (the active form of vitamin D) are different from those when natural vitamin D is added to denosumab.

Source: Prevention of Bone Events 8. 6. 2023

News Effective antiosteoporotics from the aminobisphosphonate group can finally be prescribed by general practitioners from January 2024

Osteoporosis represents a serious societal problem generating numerous health and social complications as well as considerable economic costs. In the Czech Republic, it is estimated to affect 500−750 thousand people, or 5−7% of the population. From January 1, 2024, the prescription restriction for the indication and reimbursement conditions for the medicinal products Osagrand (ibandronic acid) and Risendros (risedronic acid) will be lifted, allowing general practitioners to prescribe them as well, under the prescription conditions listed below.

Source: Treatment of Osteoporosis 12. 12. 2023

News Impact of Smoking on Postoperative Wound Healing

Modern surgery aims to shorten postoperative hospitalization by providing faster recovery from surgical consequences. Due to principles of asepsis and antisepsis, wound healing has significantly improved and the occurrence of infectious complications has decreased. However, smoking significantly prolongs recovery. We present new study results comparing wound healing in smokers and non-smokers.

Source: Wound Healing 1. 4. 2020

News Definition and Classification of Chronic Kidney Disease According to KDIGO

We provide a brief overview of the definition and classification of chronic kidney disease based on the updated KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guidelines from 2012 (published in 2013).

Source: Cardiovascular Risks 9. 10. 2023

News Prokinetics in the Treatment of Diabetic Gastroparesis

One of the common complications of diabetes mellitus is a motility disorder of the gastrointestinal tract, which can affect any part of the digestive tube, and therefore has various forms. Among these therapeutically challenging conditions is diabetic gastroparesis, which involves impaired stomach emptying.

Source: Gastrointestinal Treatment 22. 6. 2020

News A Decade of Therapy Targeting B Lymphocytes in MS

Ocrelizumab is not only a pioneer but also a highly effective and still promising modality for the treatment of multiple sclerosis (MS) with excellent patient adherence and persistence.

Source: Neurology - Multiple Sclerosis 3. 1. 2024

News Early Implementation of Highly Effective Therapy for Multiple Sclerosis

The ongoing debate about changing the approach to treating relapsing-remitting multiple sclerosis (RRMS) from an escalation strategy to the early implementation of highly effective therapy (HET) is based on the documented high inflammatory activity of the disease in its early stages and the concept of a therapeutic window for its suppression shortly after diagnosis. We bring you a summary of several recent pieces of information about the benefits and safety of HET as an initial treatment for RRMS.

Source: Neurology - Multiple Sclerosis 20. 9. 2023

Články časopisu A strategy for cardiovascular prevention: that’s what matters!

Author of the article: Michal Vrablík Source: Athero Review | 3/2019 16. 10. 2019

News H₂FPEF Score for Estimating the Probability of Heart Failure with Preserved Ejection Fraction in Persons with Unexplained Dyspnea

The simple, validated H₂FPEF scoring system based on clinical and echocardiographic parameters, developed by experts from the Mayo Clinic, allows the differentiation of heart failure with preserved ejection fraction (HFpEF) from dyspnea of other etiologies and helps decide whether further examinations are necessary. The score can be calculated online and in the Czech language.

Source: Heart Failure 23. 3. 2023