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News New Strategies in the Treatment of Schizophrenia

Schizophrenia was primarily associated with dopamine dysfunction. Previous and current treatments have mainly targeted the mesolimbic dopamine pathway in the CNS and D2 receptors. However, the cited review article primarily addresses newer treatment targets and strategies beyond the dopamine hypothesis.

Source: Schizophrenia and Antipsychotics 30. 8. 2021

News Impact of Antiemetic Prophylaxis on Quality of Life of Patients Treated with Chemotherapy –⁠ Data from Practice

Chemotherapy-induced nausea and vomiting (CINV) is a relatively common complication of cancer treatment with a significantly negative impact on patients' quality of life. A large prospective analysis of real-world clinical practice data was conducted in Germany, examining the efficacy and safety of treatment with the oral combination of netupitant and palonosetron and the impact of this therapy on patients' quality of life.

Source: Antiemetic Therapy 8. 4. 2021

News FOLFOXIRI and Panitumumab in mCRC Treatment –⁠ Improvement in Treatment Response and Metastasis Resectability

For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment, the FOLFOX (5-fluorouracil/leucovorin, oxaliplatin) or FOLFIRI (5-fluorouracil/leucovorin, irinotecan) regimens combined with monoclonal antibodies represent the standard first-line treatment. The FOLFOXIRI regimen, which is another option, was developed to further enhance the efficacy of chemotherapy. The German oncologists' VOLFI study investigated the effectiveness of combining targeted therapy and triplet chemotherapy compared to chemotherapy alone in previously untreated patients with mCRC without RAS oncogene mutation.

Source: Colorectal Cancer 21. 4. 2020

Články časopisu A severe course of acquired haemophilia A –⁠ case report

Author of the article: M. Chobola, V. Šrámek, J. Hruda Source: Anesteziologie a intenzivní medicína | 2/2012 30. 5. 2012

News Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis

A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic inflammatory markers.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 20. 6. 2022

News Recommend Erdostein for children when treating with amoxicillin –⁠ symptoms of cough improve in almost 50% of cases within 3 days

Acute respiratory infections are usually treated empirically in primary care as the causative agent is not known. Amoxicillin is among the most commonly chosen antibiotics. Erdostein is a suitable addition to this antibiotic treatment for several reasons.

Source: Cough Therapy 19. 1. 2021

News Does Administration of Saline Make a Crucial Difference Compared to Balanced Crystalloids in Critically Ill Patients?

A study published in the New England Journal of Medicine provided data on mortality and deterioration of renal function in adult patients in intensive care units, depending on whether they received saline or balanced crystalloid solutions for fluid replacement.

Source: Parenteral Nutrition 4. 10. 2021

News Effect of Telmisartan and Losartan on Bone Turnover Markers in Patients with Newly Diagnosed Stage I Hypertension

Telmisartan, an AT1 receptor blocker for angiotensin II and partial agonist of the PPAR-γ receptor, is a widely used antihypertensive. The PPAR-γ receptor plays a role in the genesis of osteoblasts and osteoclasts, and antidiabetic drugs from the thiazolidinedione group, which act as agonists of this receptor, have a known inhibitory effect on bone metabolism and increase the risk of non-traumatic fractures. Knowledge regarding the potential similar effects of telmisartan is limited. The following study compared the effects of telmisartan and losartan (an AT1 blocker without agonistic effect on PPAR-γ) on bone turnover markers in patients with newly diagnosed hypertension.

Source: Sartans in the Treatment of Hypertension 12. 8. 2021

News Can antihypertensive treatment also have a beneficial effect on neurocognitive functions?

Observational studies suggest that a desirable side effect of AT1 receptor blockers for angiotensin II (sartans) could be cognitive protection of patients. A randomized study published last year evaluated the potential positive impact of candesartan and lisinopril on neurocognitive functions in older patients with mild cognitive impairment (MCI).

Source: Sartans in the Treatment of Hypertension 14. 6. 2021

News How to Manage Thromboprophylaxis in Obese and Extremely Obese Patients?

Doctors often address the question of how to dose thromboprophylaxis in overweight individuals. The goal is to ensure effective protection against thrombotic complications in stressful situations, such as hospitalization or surgical procedures, without increasing the risk of bleeding.

Source: Thromboprophylaxis 18. 2. 2020

News Expanded Hemodialysis as an Alternative to Hemodiafiltration

Expanded hemodialysis is a new type of therapy that effectively removes middle molecules from the blood of dialysis patients. The aim of the Spanish authors was to compare its efficiency with hemodiafiltration in terms of clearance of middle molecules in an open randomized clinical study.

Source: Chronic Kidney Disease 9. 12. 2021

News Administration of Low-Molecular-Weight Heparin After Hemorrhagic Stroke: What Is the Appropriate Timing?

Hemorrhagic stroke (HS) is a condition that raises doubts and concerns about anticoagulation. Is early prevention of thromboembolic complications appropriate?

Source: Thromboprophylaxis 30. 9. 2021

News New Therapeutic Options in Light of Current Knowledge on the Pathogenesis of Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense itching and recurrent eczematous lesions. AD is diagnosed in 2 out of 10 children and often persists into adulthood. In developed countries, it is the most common skin disease with a lifetime prevalence exceeding 15%. However, it is also very diverse due to a wide range of clinical phenotypes reflecting various pathophysiological mechanisms and interactions between genetics, the immune system, and the environment. So, what have we learned about atopic dermatitis from recent research, and how has this translated into advances in its treatment?

Source: Biological Treatment 14. 11. 2022

News Romiplostim brings benefit also to patients with ITP lasting less than 1 year

What is the role of second-line therapy, in this case romiplostim, in the management of adult ITP patients who have not yet reached the chronic phase of the disease?

Source: Immune Thrombocytopenia 21. 11. 2023

News Valproate for Acute Mania: Is Practice Really Evidence-Based and Recommended?

Authors from the University of Western Ontario conducted an audit in an acute psychiatric intake unit to determine whether the prescription of valproate there corresponded to evidence-based recommendations.

Source: Bipolar Disorder 18. 2. 2020