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News Rapid Strengthening and Long-term Stabilization – New Strategy for Sequential Treatment of Severe Osteoporosis
Osteoanabolics have long been considered a treatment modality for osteoporosis that is only considered when antiresorptive medication lacks the desired efficacy. However, their role has been shifting in recent years based on new findings from clinical research, as evidenced by the conclusions of the expert working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO), whose brief summary we bring.
News Focused on MS: Statistics Are Boring, But They Have Valuable Data!
What is the prevalence of multiple sclerosis? Has the proportion of patients treated with highly effective therapy changed? We bring you the latest data from around the world and domestically.
News Incontinence Dermatitis - Common, Yet Often Overlooked Diagnosis
Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.
News CASE STUDIES on the topic of progressing interstitial lung processes
This page serves as a hub for case studies on the topic of progressing interstitial processes. The case studies aim to provide a multidisciplinary view on the rare disease topic of IPP.
News Direct Oral Anticoagulants and Their Reversal Agents – Current Options
In the last 10 years, the options for anticoagulant therapy have expanded with the introduction of direct oral anticoagulants (DOACs). It appears that DOACs may soon replace warfarin in the first line of prevention of venous thromboembolism, not only due to their clinical advantages but also thanks to newly available reversal agents that can be administered in case of major bleeding in patients taking DOACs. A recently published review article summarizes the current situation in this area.
News Current View on Gestational Diabetes Mellitus in Theory and Practice
We dedicated one of the episodes of our podcast meditalks+ to the issue of gestational diabetes mellitus (GDM), focusing on aspects of care related to general practitioners. In a conversation with Associate Professor MUDr. Ludmila Brunerová, Ph.D., from the Diabetology Center at the Faculty Hospital Královské Vinohrady in Prague, we now continue with a more detailed look at selected questions that will also interest specialists.
News How Does Cenobamate Compare with Third-Generation Anti-Seizure Medications in Terms of Cost-Effectiveness?
The main goal of epilepsy treatment is to achieve seizure freedom without unacceptable side effects of therapy. Despite the benefits of the latest generation of anti-seizure medications (ASMs), approximately 40% of patients suffer from drug-resistant epilepsy. The recently approved cenobamate brings new hope to patients. A Spanish pharmacoeconomic study aimed to compare the cost-effectiveness of cenobamate with selected third-generation ASMs as adjunctive therapy in patients with drug-resistant focal epilepsy.
News Dupilumab Now Covered for Atopic Dermatitis in Children Older Than 6 Years
Dupilumab is now fully covered by public health insurance for pediatric patients from 6 years old with atopic dermatitis. This opens up a new possibility for pediatric patients with this condition to improve their quality of life.
News Long-term Benefit of Sotorasib for Survival of Patients with Pre-treated Advanced/Metastatic NSCLC with G12C Mutation of KRAS Oncogene
Sotorasib is indicated as monotherapy for advanced non-small-cell lung cancer (NSCLC) with the KRASG12C gene mutation, if there has been progression after ≥ 1 prior line of systemic therapy. The 2-year analysis of data from the CodeBreaK 100 study published in April 2023 demonstrated the long-term benefit of sotorasib for this patient population in terms of progression-free survival (PFS) and overall survival (OS), regardless of programmed death-ligand 1 (PD-L1) receptor expression, including patients with a poor prognosis. In the Czech Republic, sotorasib has been reimbursed by public health insurance for this indication since September 2023.
News Frequent Nausea During Chemotherapy Despite Antiemetic Prophylaxis
Current clinical research has focused on vomiting as a primary issue in the occurrence of CINV (chemotherapy-induced nausea and vomiting) and, using recommended antiemetic prophylaxis, this problem has been relatively well managed. However, the incidence and impact of nausea are underreported. We present the results of an observational study that evaluated the incidence of nausea in patients undergoing chemotherapy.
News Over the Last 25 Years, Latanoprost Has Changed the Paradigm of Glaucoma Treatment
An important milestone in the treatment of glaucoma was the introduction of latanoprost with an entirely new mechanism of action compared to previously used antiglaucoma medications. Prostaglandin analogs (PGAs) have become the first-line treatment for primary open-angle glaucoma (POAG) primarily due to their efficacy, once-daily dosing, and minimal systemic side effects. The following recent review briefly summarizes the impact of the introduction of PGAs 25 years ago on current clinical practice in the treatment of glaucoma.
News Hope Awakens with Early Diagnosis of Parkinson's Disease Based on Skin Odor
According to scientists from the United Kingdom, a simple test based on an individual's skin odor could aid the early diagnosis of Parkinson's disease. A study has already been launched to investigate the chemicals secreted by the skin of patients with Parkinson's disease.
News Aloe vera Extract in the Therapy of Irritable Bowel Syndrome
The therapy options for irritable bowel syndrome are relatively limited, thus complementary and alternative treatments besides conventional therapy are applied. Many patients report that using Aloe vera extract helps reduce their disease symptoms, although there is a lack of valid evidence from clinical studies. The pilot study presented below focused on evaluating the efficacy of Aloe vera extract compared to placebo in several dozen patients with irritable bowel syndrome.
News Effect of Beta-Blockers on Glucose Metabolism and Their Use in Diabetics with Hypoglycemic Episodes
Beta-blockers, through their mechanism of action, can lead to the deepening or direct initiation of both hypoglycemia and hyperglycemia. The study presented below, published last year, evaluated the impact of beta-blocker treatment, their selectivity, and the predisposition of patients to hypoglycemia on the risk of mortality.
News Bilastine as a reliable helper in the treatment of allergic rhinoconjunctivitis and urticaria even in younger children
Until recently, bilastine was indicated for the treatment of allergic rhinoconjunctivitis and urticaria only in patients over 12 years of age. However, current findings from valid studies demonstrate the safety and efficacy of its use even in younger individuals.
News Interactive Case Study: Use of Cannabis Extract for Local Treatment of Neuropathic Pain
We have been using cannabis for pain treatment for several years. We also have good experiences with it in difficult-to-control symptoms of neuropathic pain, as illustrated in the following case study. Until recently, our patients only used cannabis orally or via vaporization. With the availability of cannabis extracts, a new option has emerged – local therapy.
News How and when does the reaction to gluten begin in coeliac disease? A new Canadian study offers potential answers
As is well known, coeliac disease is a systemic autoimmune disorder characterised by damage to intestinal epithelial cells (IEC). Canadian researchers have sought to uncover the relationship between intestinal epithelial cells and T lymphocyte activation in this disease. The results of their work provide hope for the potential development of an effective therapy.
News Meta-analysis of Efficacy and Safety of Third-Generation Antiseizure Medications in Adjunctive Treatment of Focal Seizures in Adults with Epilepsy
Epilepsy treatment is primarily symptomatic, aimed at reducing seizure frequency. However, more than 50% of patients do not achieve seizure freedom with monotherapy. Below we summarize the results of a meta-analysis comparing the efficacy and safety of third-generation antiseizure medications in the treatment of focal seizures in adults with epilepsy.
News Monitoring Limits in Prescribing Incontinence Aids is Essential
The amendment to the Public Health Insurance Act, which came into effect in December 2019, brought many changes in the reimbursement of medical aids through prescriptions. The methodology for determining the degree of incontinence has changed, and it is now also possible to combine aids according to the individual needs of the patient. We summarize other novelties related to limits issues in the following text.
News Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain
Painful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and pregabalin. The meta-analysis, whose conclusions we summarize below, focused on comparing their effectiveness and tolerability.
News Comparison of 5 Beta-Blockers in Heart Failure with Reduced Ejection Fraction
An analysis of 26 studies with beta-blockers in the treatment of heart failure with reduced ejection fraction compared 5 drugs (bisoprolol, metoprolol-succinate, metoprolol-tartrate, carvedilol, and nebivolol). The results showed a more favorable prognosis with bisoprolol compared to carvedilol, a similar effect on prognosis for carvedilol, metoprolol-succinate, and nebivolol, and the least favorable prognosis with metoprolol-tartrate.
News How to Detect COPD Early in Primary Care?
Chronic obstructive pulmonary disease (COPD) can be present even in individuals without obvious subjective symptoms, or the emerging symptoms may be overlooked by both the patient and the doctor due to their very gradual development. So, what is the path to early detection of COPD in primary care, and how can this disease be distinguished from others accompanied by similar manifestations?