Cardiovascular studies and gliflozins


Authors: Jindřich Špinar 1;  Lenka Špinarová 2;  Jiří Vítovec 2
Authors‘ workplace: Fyziologický ústav LF MU, Brno 1;  I. interní kardioangiologická klinika, LF MU a FN u sv. Anny v Brně 2
Published in: Forum Diab 2019; 8(3): 200-207
Category:

Overview

Diabetes mellitus type 2 is an epidemy of the 21st century. The Food and Drug Administration (FDA) announced that cardiovascular safety after peroral antidiabetics is a more important goal than the lowering of glycemia and this was the beginning of a large program with antidiabetics and cardiovascular goals. The guidelines for heart failure accent the positive effect of SGLT2 inhibitors with the indication IIa in 2016. Two important European docu­ments on antidiabetics and cardiovascular outcomes called position statement were published by the European Society of Cardiology in 2018, especially on the effect of heart failure. “An expert concensus meeting report of the HFA of the ESC,” will be published in autumn 2019 and the first part is about SGLT2 – gliflozins. Clinical study DAPA –HF was presented on ESC congress in september 2019 and showed positive effect of dapagliflozin on heart failure.

Keywords:

diabetes mellitus – gliflozins – heart failure – mortality


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Labels
Diabetology Endocrinology Internal medicine
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