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Fatální případ abusu sirupu proti kašli
: H. Kinoshita; N. Tanaka; M. Jamal; M. Kumihashi; R. Okuzono; K. Ameno
: Department of Forensic Medicine, Faculty of Medicine, Kagawa University
: Soud Lék., 57, 2012, No. 4, p. 69-70
: Original Article
Popsán fatální případ abúzu sirupu proti kašli, obsahující chlorpheniramin a dihydrokodein. Koncentrace chorpheniraminu po smrti byla v krvi nad smrtící úrovní, ale koncentrace dihydrokodeinu byla v terapeutickém pásmu a tyto hodnoty byly diskutovány z hlediska forenzní farmakokinetiky. Usuzujeme, že příčinou smrti byla otrava chlorpheniraminem.
Klíčová slova:
abusus sirupu proti kašli – chlorpheniramin – dihydrokodein
Sources
1. Saukko P, Knight B. Knight’s Forensic pathology, (3rd ed). London, Hodder Arnold: 2004.
2. Taguchi H, Suyama M, Misumi S, Senoo E. Mental disorders induced by the over-the-counter antitussive syrups not containing methylephedrine. Jap J Clin Psychiatry 2002; 31 : 1107–1117.
3. Reed D. A fatal case involving chlorpheniramine. Clin Toxicol 1981; 18 : 941–943.
4. Winek CL, Wahba WW, Winek CL Jr, Balzer TW. Drug and chemical blood-level data 2001. Forensic Sci Int 2001; 122 : 107–123.
5. Baselt RC. Disposition of toxic drugs and chemicals in man, (8th ed). Foster City, CA: Biochemical Publications: 2008
6. Skidgel RA, Erdös EG. Histamine, bradykinin and their antagonists. In: Brunton LL, Lazo JS, Parker KL. eds. Goodman & Gilman’s The pharmacological basis of therapeutics (11th ed). New York, McGraw-Hill: 2006, pp. 629–651.
7. Murao S, Manabe H, Yamashita T, Sekikawa T. Intoxication with over-the-counter antitussive medication containing dihydrocodeine and chlorpheniramine causes generalized convulsion and mixed acidosis. Inter Med 2008; 47 : 1013–1015.
Labels
Anatomical pathology Forensic medical examiner Toxicology
Article was published inForensic Medicine
2012 Issue 4-
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