Adverse effects of anticholinergics used in the treatment of overactive bladder  on the central nervous system

Overview

Administration of anticholinergics represents the mainstay of overactive bladder therapy Their efficacy has been proven in a number of large randomized tri als Recently, much attention has been paid to the ad verse effects of anticholinergics used in the treatment of overactive bladder on the central nervous system Current literature evidence shows a low but real risk of cognitive impairment and the development of dementia with long‑term use of anticholinergics, particularly oxybutynin and tolterodine Before start ing anticholinergic therapy, the benefits and potential risk should be carefully considered for each individual patient Particular caution is required in patients with pre‑existing cognitive impairment If anticholinergic treatment fails or side effects occur, alternative treat ment options should be considered early

Keywords:

Overactive bladder, anticholinergics, muscarinic receptors, cognitive impairment, dementia