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Atypical smooth muscle neoplasia of the prostate of uncertain malignant potential – leiomyoma/leimyosarcoma of the prostate


Authors: Ágnes Juhász 1,3;  Markéta Matějková 1;  Miroslav Záleský 1,2;  Kamil Belej 1,2
Authors‘ workplace: Urologické oddělení, Ústřední vojenská nemocnice – Vojenská fakultní nemocnice, Praha 1;  Urologická klinika, 1. lékařská fakulta, Univerzita Karlova, Praha 2;  Urologické oddělení, Oblastní nemocnice Kladno, a. s., Kladno 3
Published in: Ces Urol 2020; 24(4): 284-288
Category: Case reports

Overview

Juhász Á, Matějková M, Záleský M, Belej K. Atypical smooth muscle neoplasia of the prostate of uncertain malignant potential – leiomyoma/ leimyosarcoma of the prostate.

Both prostate leiomyoma and leiomyosarcoma are extremely rare mesenchymal prostate tumors. 

The prognosis and therapy of these diseases is however significantly different. We present a case of a 54-year-old man who was found to have a paraprostatic lesion with low prostate specific antigen during a rectal examination. Transrectal prostate biopsy was performed, followed by pelvic magnetic resonance imaging and rectoscopy. None of the examinations confirmed the presence of malignant cells or the suspicion of malignancy. The is asymptomatic patient was followed up by his outpatient urologist for two years. With the development of symptoms a control MRI of the pelvis was indicated with the finding of growth progression of the lesion with central necrotization and with suspicion of malignant character, which already oppressed the prostate and part of the urethra. For the findings described above pelvic revision was indicated with an eventual radical prostatectomy. Histological examination of the specimen from robotic assisted radical prostatectomy showed atypical smooth muscle neoplasia of the prostate of uncertain malignant potential – leiomyoma with borderline changes with leiomyosarcoma.

Keywords:

Leiomyoma – Leiomyosarcoma – Prostate carcinoma


Sources

1. Murer LM, Talmon GA. Stromal tumor of uncertain malignant potential of the prostate. Arch Pathol Lab Med 2014; 138 (11): 1542–1545.

2. Ringroir A, Rappe B, Dhaene K, Schallier D. Prostatic leiomyoma: a case report. Urol Case Rep 2016; 9: 45–47.

3. Záťura F, Fiala R, Študent V. Leiomyom prostaty a peroperační komplikace při jeho exstirpaci. Ces Urol 1998; 2: 18-19.

4. Chen W, Han D, Fu G, Lin W, Liang Y. Long term follow‑up of surgery management of prostate leio‑ myosarcoma metastasized to the rib: a case report and literature review. Mol Clin Oncol 2016; 5: 132–134.

5. Zazzara M, Divenuto L, Scarcia M, et al. Leiomyosarcoma of prostate: case report and literature review. Urol Case Rep 2018; 17: 4–6.

6. Singh JP, Chakraborty D, Bera MK, Pal D. Leiomyosarcoma of prostate: a rare, aggressive tumor. J Cancer Res Ther 2013; 9: 743–745.

7. Venyo AK. A review of the literature on primary leiomyosarcoma of the prostate gland. Adv Urol 2015; 2015: 485786.

Labels
Paediatric urologist Nephrology Urology

Article was published in

Czech Urology

Issue 4

2020 Issue 4

Most read in this issue
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