Peripheral arterial disease of lower extremity and global cardiovascular risk


Authors: Denisa Čelovská;  Viera Štvrtinová
Authors‘ workplace: I. Interná klinika LF UK a UNB, Bratislava
Published in: AtheroRev 2018; 3(1): 21-28
Category: Reviews

Overview

Peripheral arterial disease (PAD) of lower extremity is predominantly a manifestation of atherothrombotic process. Effective cardiovascular risk treatment is underestimated in clinical practice despite significantly increased cardio-cerbro-vascular mortality and morbidity in symptomatic and even in asymptomatic PAD patients. There is a high prevalence of asymptomatic PAD patients that can be detected by an ankle-brachial index (ABI). In PAD patients systolic hypertension is commonly associated with a high pulse pressure and non-dipping pattern. Smoking, diabetes mellitus and atherogenic dyslipidemia are significant risk factors for cardiovascular risk stratification in PAD patients. PAD patients have very high CV risk and the goal level of LDL cholesterol is less than 1,8 mmol/l or even lower according to new studies. What cannot be forgotten is modification of life-style especially in reduction of remnant lipoproteins, which play an important role in peripheral circulation.

Key words:
arterial hypertension, cardiovascular risk, diabetes mellitus, dyslipidemia, peripheral arterial disease of lower extremity

Received:
10. 12. 2017

Accepted:
4. 1. 2018


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