#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Possible treatment of anogenital warts with the immunomodulation agent Isoprinosine


Authors: Michal Mihula
Authors‘ workplace: Klinické oddělení gynekologie a porodnictví, Městská nemocnice Ostrava
Published in: Prakt Gyn 2015; 19(2): 101-106
Category: Gynecology and Obstetrics: Review Article

Overview

Condylomata acuminata present a considerable epidemiological problem, particularly in a teenage population. The illness develops through the infection by a human papillomavirus- HPV. We are unable to treat the human papillomavirus, therefore the treatment of anogenital warts largely only consists in local destruction of warts and does not treat the cause of the illness. The removing of warts itself, in particular when the affected site is larger-sized, can be difficult and protracted, as well as subsequent healing of the patient, often complicated by recurrences. Any new preparation that broadens the possibilities of treatment of this obtrusive illness means a great benefit. In this regard the overall effect of the immunomodulation preparation Isoprinosine is a great hope for patients, mainly due to its systemic effect on all cutaneous and mucosal surfaces, its patient friendliness, but mainly due to its assumed ability to reduce the percent of recurrence. At the outpatients‘ department of oncogynecological prevention affiliated to the Department of Obstetrics and Gynecology of the Ostrava City Hospital and its Laser centre, we followed the effect of the treatment with Isoprinosine in clinical practice and the results are very encouraging. Based on our observations we also try to provide guidance on how to use the medicine, on its dosing and length of application. For the sake of interest we present 1 case study with photo documentation, in which we have used Isoprinosine treatment with a very good effect.

Key words:
anogenital wart – HPV – inosinum pranobexum – Isoprinosine


Sources

1. Kederova AG, Podisov YI, Kuznetsov VV et al. Role of antiviral therapy in the complex treatment of patients with epithelial dysplasias and preinvasive cancer of the cervix uteri. Akušerstvo i ginekologia 2006; (6): 27–30.

2. Georgala S, Katoulis AC, Befon A et al. Oral inosiplex in the treatment of cervical condylomata acuminata: a randomised placebo-controlled trial. BJOG 2006; 113(9): 1088–1091.

3. Fait T, Dvořák V, Skřivánek A et al. Epidemiologie genitálních bradavic mezi ženami v České republice. HPV college 2010. Dostupné z WWW: <http://www.hpv-guide.cz/epidemiologie-genitalnich-bradavic-mezi-zenami-v-ceske-republice>.

4. Prix Galien. Dostupné z WWW: <http://www.prixgalien.com/en/05/02/winners-sorted-by-medical-field.htm>.

5. Co je HPV. Dostupné z WWW: <http://www.hpv-guide.cz/hpv-krok-po-kroku/co-je-hpv>.

6. ALDARA 5 % krém. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_Product_Information/human/000179/WC500023122.pdf>.

7. ISOPRINOSINE. POR TBL NOB 100X500MG. SPC – Souhrn údajů o přípravku. Dostupné z WWW: <http://www.sukl.cz/modules/medication/detail.php?code=0162748&tab=texts>.

8. Davidson-Parker J, Dinsmore W, Khan MH et al. Immunotherapy of genital warts with inosine pranobex and conventional treatment: double blind placebo controlled study. Genitourin Med 1988; 64(6): 383–386.

9. Robová H, Rob L, Pluta M et al. Prekancerózy děložního hrdla. Patogeneze : Onkologická prevence v gynekologii. Mod Gynek Porod 2003; 12(4): 627–630.

10. Sadoul G, Beuret T. Treatment of cervical and vulvar condylomata with CO2 laser combined with an immunostimulant. Rev Fr Gynecol Obstet 1984; 79(11): 681–684.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Practical Gynecology

Issue 2

2015 Issue 2

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#