Process of age-related decline of brain function among non-smokers and smokers
Authors:
D. Hrubá; A. Peřina
Authors‘ workplace:
Přednostka: prof. MUDr. Zuzana Derflerová Brázdová, DrSc.
; Lékařská fakulta
; Ústav ochrany a podpory zdraví
; Masarykova univerzita, Brno
Published in:
Prakt. Lék. 2016; 96(1): 9-13
Category:
Reviews
Overview
Cardiovascular disease, chronic obstructive pulmonary disease and various forms of cancer are strongly associated with smoking. Now there is substantial epidemiologic evidence that smoking is also associated with impairment of brain functions (reduce of cognitive performances) as well as with some severe psychiatric morbidity, especially Alzheimer’s disease and senile dementia. These symptoms and diseases are prevalent more often among smokers; their onset is in earlier age, even in middle age, and more rapid progression. Many clinical and experimental studies described the probable mechanisms of smoking influence: hypoxemia, free radicals, role of nicotinic acetylcholine receptors (nAChRs), neurotoxicity for neurons and reduced thickness of brain cortex.
Health consequences of neurotoxic influence of smoking are raising health and socioeconomic problem, especially due to demographic ageing. Primary prevention of smoking and smoking cessation is the most effective methods for healthier elderly.
Keywords:
smoking – memory – cognition – Alzheimer disease – mechanisms of pathogenesis
Sources
1. Anstey, KJ, von Sanden, C, Salim, A, O´Kearney B. Smoking as a risk factor for dementia and cognitive decline: A meta analysis of prospective studies. Am J Epidemiol 2007; 166: 367–378
2. Astrid C, Nooyens J, Boukje M, et al. Smoking and cognitive decine among middle-aged men and women: the Doetinchem Cohort Study. Am J Public Health 2008; 98: 1–7.
3. Barnes DE, Yaffe K. The projected effect of risk factor reducing on Alzheirmer’s disease prevalence. Lancet Neurol 2011; 10: 819–828.
4. Bechara A. Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nat Neurosci 2005; 8: 1458–1463.
5. Bernardi RE. Advances in nicotine research in addiction biology. Add Biol 2015; 20(5): 877–889. doi: 10.1111/adb.12269. Epub 2015 May 22.
6. Braak H, Zetterberg H, Del Tredici K, Blennow K. Intraneuronal tau aggregation precedes difusse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol 2013; 126: 631–634.
7. Buckner RL. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron 2004; 44: 195–208.
8. Cataldo JK, Prochaska JJ, Glantz SA. Cigarette smoking is a risk factor for Alzheimer´s disease: an analysis controlling for tobacco industry affiliation. J Alzheimers Dis 2010; 19: 465–480.
9. Dregan A, Stewart R, Gullifors MC. Cardiovascular risk factors and cognitive decline in adults aged 50 and over: A population-based cohort study. Age Ageing 2013; 42(3): 338–345. doi: 10.1093/ageing/afs166. Epub 2012 Nov 25.
10. Durazzo TC, Meyerhoff, DJ, Nixon, SJ. Chronic cigarette smoking: implications for neurocognition and brain neurobiology. Int J Environ Res Public Health 2010; 7: 3760–3791.
11. Durazzo TC, Mon A, Gatdzinski S, Meyerhoff DJ. Chronic cigarette smoking and alcohol dependence: associations with cortical thicknes and N-acetylaspartate levels in the extended brain reward systém. Addict Biol 2013; 18: 379–391.
12. Durazzo TC, Mattsson N, Weiner MW. Smoking and increased Alzheimer´s disease risk: A review of potential mechanisms. Alzheimers Dement 2014; 10: S122–S145.
13. Ferrea S, Winterer G. Neuroprotective and neurotoxic effects of nicotine. Pharmacopsychiatry 2009; 42: 1–11.
14. Gallinat J, Meisenzahl E, Jacobse LK, et al. Smoking and structural brain deficit: a volumetric MR investigation. Eur J Neurosci 2006; 24: 1744–1750.
15. George TP, Vessicchio JC. Nicotine addiction and other psychiatric disorders. Psychiatric Times 2001; 18(2) [on-line]. Dostupné z: http//www.psychiatrictimes.com/articles/nicotine-addiction-and-other-psychiatric-disorders
16. Hughes JR. Co-morbidity and smoking. Nicotine Tob Res 1999; 1: S149–S152.
17. Iglesias C, López G, Alonso MJ. Effects of smoking ban in a general hospital psychiatric unit. Actas Esp Psiquiatr 2008; 36: 60–62.
18. Janson AM, Fuxe K, Goldstein M. Different effects of acute and chronic nicotine treatmen on MTPT (1-metyl-4-fenyl-1,2,3,6-tetrahydropyridin) induced degeneration of nigrostrial dopamine neurons in the black mouse. Clin Invest 1992; 70: 232–238.
19. Karama S, Durcharme S, Corley J, et al. Cigarette smoking and thinning of the brain’s cortex. Molecular Psychiatry 2015; 20: 778–785; doi: 10.1038/mp.2014.187; published online 10 February 2015.
20. Kühn S, Schubert F, Gallinat J. Reduced thickness of medial orbitofrontal cortex in smokers. Biol. Psychiatry 2010; 68(11): 1061–1065. doi: 10.1016/j.biopsych.2010.08.004. Epub 2010 Sep 27.
21. Leonard S, Bertrand D. Neuronal nicotinic receptors: from structure to function. Nicotine Tob Res 2000; 3: 203–223.
22. Leonard S, Breese C, Adams C, et al. Smoking and schizophrenia: abnormal nicotinic receptor expression. Eur J Pharmacol 2000; 393: 237–242.
23. Li J, Huang Y, Feai GH. The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease. Respiration 2013; 85: 98–105.
24. Lin F, Wu G, Zhu L, Lei H. Altered brain functional networks in heavy smokers. Addiction Biol 2015; 20(4): 809–819. doi: 10.1111/adb.12155. Epub 2014 Jun 24.
25. Lotfpour S, Ferguson E, Leonard G, et al. Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype. Arch Gen Psychiatry 2009; 66: 1244–1252.
26. Ono K, Hirohata M, Yamada M. Anti-fibrillogenic and fibril–destabilizing activity of nicotine in vitro: Implications for the prevention and therapeutics of Levy body diseases. Exp Neurol 2007; 205: 414–424.
27. Perry E, Martin-Ruiz C, Lee M, et al. Nicotine receptor subtypes in human brain aging. Alzheimer’s and Lewy body diseases. Eur J Pharmacol 2000; 393: 215–222.
28. Piccioto MR, Zoli M, Lena V, et al. Nicotinic receptors in aging and dementia. J Neurobiol 2002; 53: 641–655.
29. Pomerlau CS, Marks JL, Pomerlau OF. Who gets what symptom? Effects of psychiatric cofactors and nicotine dependence on patterns of smoking withdrawal symptomatology. Nicotine Tob Res 2000; 2: 275–280.
30. Russanen M, Kivipelto M, Quesenberry CP, et al. Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer’s disease: a population based cardiovascular risk factors, aging and dementia study. Dement Geriatr Cogn Disord 2010; 30: 277–284.
31. Sabia S, Marmot M, Dufouil C, Manoux AS. Smoking history and cognitive function in middle age from the Whitehall II study. Arch Intern Med 2008; 168(11): 1165–1173.
32. Sutherland GT, Chami B, Yousef P, Witting PK. Oxidative stress in Alzheimer’s disease: primary vilain or physiological by-product? Redox Rep 2013, 18: 134–141.
33. Thacker EL, O’Reilly JO, Weisskopf MG, et al. Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology 2007; 68: 764–768.
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