proLékař CzMA JEP journals Premium account Contact us
CzMA JEP: Current issue
About the journal
Editorial Board
For authors and reviewers
Contact us
Křišťálová Lupa 2014

Mediastinal ganglioneuroma with perineural cell differentiation. Report of a case

Authors: Zámečník M., Chlumská A., Ondriaš F.

Authors - sphere of activity: 1Alpha Medical Pathology, s.r.o., Bratislava, Slovak Republic; 2Šikl`s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic; 3Laboratory of Surgical Pathology, Pilsen, Czech Republic

Article: Čes.-slov. Patol., 48, 2012, No. 2, p. 94-96
Category: Original Articles
Number of articles displayed: 118x

Specialization: Anatomical pathology Forensic medical examiner Toxicology


An unusual case of ganglioneuroma with perineural cell differentiation is presented. The tumor was removed from the mediastinum in a 34-year-old male patient. Histologically, it contained neuroid bundles of bland spindle cells, scattered ganglion cells, and some foci of adipocytic metaplasia. Immunohistochemically, the tumor showed expected expressions of S100 protein, neurofilament protein and calretinin. In addition, many spindle cells were positive for perineural cell markers EMA, claudin-1, and GLUT-1. These cells were often arranged in an organoid fashion around the schwannoid bundles. This case indicates that the cells of ganglioneuroma can mature simultaneously towards both Schwann cell and perineural cell phenotypes.

ganglioneuroma – perineurioma – EMA – claudin-1 – GLUT-1



The full wording of this article is available only to registered users. Plese register and you can read this article immediately.


If you are a subscriber, log in and enter the subscriber code from your magazine cover.

If you are not a subscriber, log in for unlimited access to older editions.



Unlock article

You can read this article if you activate Premium account.


Hodnocení článku

Rate article:     0/5, evaluated 0x

Most read