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MEDIASTINAL GANGLIONEUROMA WITH PERINEURAL CELL DIFFERENTIATION. REPORT OF A CASE

Authors: Zámečník M.1, Chlumská A.2,3, Ondriaš F.1

Authors - sphere of activity: 1Alpha Medical Pathology, s.r.o., Bratislava, Slovak Republic; 2Šikl`s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic; 3Laboratory of Surgical Pathology, Pilsen, Czech Republic

Article: Čes.-slov. Patol., 48, 2012, No. 2, p. 94-96
Category: Original Articles
Number of articles displayed: 129x

Specialization: Anatomical pathology Forensic medical examiner Toxicology

Summary


An unusual case of ganglioneuroma with perineural cell differentiation is presented. The tumor was removed from the mediastinum in a 34-year-old male patient. Histologically, it contained neuroid bundles of bland spindle cells, scattered ganglion cells, and some foci of adipocytic metaplasia. Immunohistochemically, the tumor showed expected expressions of S100 protein, neurofilament protein and calretinin. In addition, many spindle cells were positive for perineural cell markers EMA, claudin-1, and GLUT-1. These cells were often arranged in an organoid fashion around the schwannoid bundles. This case indicates that the cells of ganglioneuroma can mature simultaneously towards both Schwann cell and perineural cell phenotypes.

Keywords:
ganglioneuroma – perineurioma – EMA – claudin-1 – GLUT-1

 

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