Granulosa Cell Tumor - Clinical Group and Review of

Overview

Objective:
To present a review of literature and to analyse a clinical retrospective series of pa-tients with granulosa cell tumor.Design: Retrospective study and review.Setting: Department of Obstetrics and Gynaecology, First Faculty of Medicine, Prague, CzechRepublic.Methods: Retrospective analysis of age, stage, surgery, radiotherapy and chemotherapy, survivalcurve, number of recurrences and time to recurrence. Literature and information database (Med-line 1997-1999) review.Results: In a group of 43 patients the median of age was 53.5 years. 83.7% of cases were in a stage I.There were two duplicite tumors in a series. Conservative surgery was performed in 9/43 cases, 5of them were reoperated on. The most frequent chemotherapy regimens were platinum-cyclo-phoshamide and BEP (bleomycin, etoposide, platinum). The 5-year overall survival was 86% andspecific survival 90.7%. There were 3/43 recurrences, median time to recurrence was 22 months.Conclusion: A good prognosis of a patient with granulosa cell tumor requires a precise histopa-thologic examination, an adequate surgery and a comprehensive clinical analysis of a case toevaluate an indication of adjuvant therapy. Concentration of patients in oncogynaecological cen-tres is advisable. A careful follow-up because of a risk of late recurrences is necessary.

Key words:
granulosa cell tumor, ovary