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Insights into the pathogenesis of autism spectrum disorders from the molecular and cellular level


Authors: A. Strunecká 1;  R. L. Blaylock 2
Authors‘ workplace: Laboratoř biochemické neurofarmakologie Ústavu lékařské biochemie 1. LF UK Univerzita Karlova, Praha Přednosta: prof. MUDr. Stanislav Štípek, DrSc. ;  Belhaven College, Jackson, Mississippi, USA 2
Published in: Prakt. Lék. 2008; 88(2): 78-81
Category: Various Specialization

Overview

Despite the great array of observations, the etiopathogenesis of the autism spectrum disorders (ASD) is poorly defined. Our review offers evidence that most heterogeneous symptoms of ASD might have a common set of pathophysiological events at cellular level closely connected with dysregulation of glutamatergic neurotransmission in the brain with excitotoxicity as a common underlying mechanism. The suggested unifying hypothesis offers the means for efficient prevention and amelioration of ASD.

Key words:
autism, excitotoxicity, glutamatergic neurotransmission, excitatory amino acids.


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