The role of C-reactive protein levels on the association of physical activity with lung function in adults


Autoři: Elaine Fuertes aff001;  Anne-Elie Carsin aff001;  Vanessa Garcia-Larsen aff005;  Stefano Guerra aff001;  Isabelle Pin aff007;  Bénédicte Leynaert aff010;  Simone Accordini aff012;  Jesús Martinez-Moratalla aff013;  Josep M. Antó aff001;  Isabel Urrutia aff015;  Audrey Le Gouellec aff016;  Joachim Heinrich aff017;  Thorarinn Gislason aff019;  Rain Jõgi aff020;  Christer Janson aff021;  Debbie Jarvis aff004;  Judith Garcia-Aymerich aff001
Působiště autorů: ISGlobal, Barcelona, Spain aff001;  Universitat Pompeu Fabra (UPF), Barcelona, Spain aff002;  CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain aff003;  National Heart and Lung Institute, Imperial College London, London, United Kingdom aff004;  Program in Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America aff005;  Asthma and Airway Disease Research Center, University of Arizona - Tucson, Arizona, United States of America aff006;  Department of Pediatrics, CHU Grenoble Alpes, Grenoble, France aff007;  INSERM, Institut for Advanced Biosciences, Grenoble, France aff008;  University Grenoble Alpes, Grenoble, France aff009;  UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, INSERM, Paris, France aff010;  UMR 1152, University Paris Diderot Paris, Paris, France aff011;  Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy aff012;  Servicio de Neumologia del Complejo, Servicio de Salud de Castilla – La Mancha (SESCAM), Hospitalario Universitario de Albacete, Albacete, Spain aff013;  Facultad de Medicina de Albacete, Universidad de Castilla - La Mancha, Albacete, Spain aff014;  Department of Respiratory, Galdakao Hospital, Galdakao, Spain aff015;  University Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France aff016;  Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Munich, Germany aff017;  Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich, Ludwig Maximilians University Munich, Munich, Germany aff018;  Department of Respiratory Medicine and Sleep, Landspitali University Hospital Reykjavik, Reykjavik, Iceland aff019;  Lung Clinic, Tartu University Hospital, Tartu, Estonia aff020;  Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden aff021;  MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom aff022
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222578

Souhrn

Objective

Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, which is a common marker of systemic inflammation, on the association of physical activity with forced expiratory volume in one second and forced vital capacity.

Methods

Cross-sectional data on spirometry, C-reactive protein levels and self-reported physical activity (yes/no; ≥2 times and ≥1hr per week of vigorous physical activity) were available in the European Community Respiratory Health Survey (N = 2347 adults, 49.3% male, 28–56 years-old). A subsample was also assessed 10 years later using the International Physical Activity Questionnaire, and tertiles of Metabolic Equivalent of Task—minutes per week spent in vigorous, moderate and walking activities were calculated (N = 671, 49.6% male, 40–67 years-old). Adjusted cross-sectional mixed linear regression models and the “mediate” package in “R” were used to assess the presence of mediation.

Results

Despite positive significant associations between nearly all physical activity metrics with forced expiratory volume in one second and forced vital capacity, there was no evidence that C-reactive protein levels played a role. An influence of C-reactive protein levels was only apparent in the smaller subsample when comparing the medium to low tertiles of moderate activity (mean difference [95% CIs]: 21.1ml [5.2, 41.9] for forced expiratory volume in one second and 17.3ml [2.6, 38.0] for forced vital capacity).

Conclusions

In a population of adults, we found no consistent evidence that the association of physical activity with forced expiratory volume in one second or forced vital capacity is influenced by the level of C-reactive protein in blood.

Klíčová slova:

Inflammation – Physical activity – Professions – Pulmonary function – Questionnaires – Smoking habits – C-reactive proteins – Health surveys


Zdroje

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PLOS One


2019 Číslo 9

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