#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis


Autoři: Tesfalidet Tekelab aff001;  Catherine Chojenta aff001;  Roger Smith aff003;  Deborah Loxton aff001
Působiště autorů: Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia aff001;  College of Medical and Health sciences, Wollega University, Nekemte, Oromia, Ethiopia aff002;  The Mothers and Babies Research Centre at the Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222566

Souhrn

Background

Newborns are at greatest risk of dying at and shortly after the time of birth. Newborn mortality remains an urgent concern and is an important indicator of child health, development and well-being. Studies examining the effectiveness of antenatal care on maternal and newborn health outcomes have provided conflicting results. The aim of this review and meta-analysis was to determine the pooled effect of antenatal care on neonatal mortality in sub-Saharan Africa.

Methods

We searched PubMed, Medline, EMBASE, CINAHL and Google Scholar from September to November 2016 and then updated our search on April 13, 2019. Two independent reviewers extracted data from eligible studies. The quality of each included study was assessed using the Risk of Bias Assessment tool for Non-Randomized Studies (RoBANS). The results were reported based on risk ratio (RR) with 95% confidence intervals (CI) using a random-effects model.

Results

Eight hundred and ninety eight studies were initially identified. During screening, 23 studies were found to be relevant for data extraction. Of these, only twelve studies fulfilled the inclusion criteria and were included in the analysis. In five of the twelve studies included in the analysis, antenatal care service utilization had a significant association with neonatal mortality. The pooled risk ratio by the random-effects model was 0.61 (95% CI: 0.43, 0.86) for neonates born to women who received at least one antenatal care visit by a skilled provider as compared to neonates born to women who did not receive antenatal care.

Conclusion

This review indicates that utilization of at least one antenatal care visit by a skilled provider during pregnancy reduces the risk of neonatal mortality by 39% in sub-Saharan African countries. Thus, in order to accelerate progress towards the reduction of newborn deaths, all pregnant women should receive antenatal care during pregnancy.

Klíčová slova:

Biology and life sciences – Developmental biology – Neonates – Population biology – Population metrics – Death rates – Medicine and health sciences – Women's health – Maternal health – Antenatal care – Pregnancy – Obstetrics and gynecology – Pediatrics – Neonatology – Neonatal care – Health care – People and places – Geographical locations – Africa – Research and analysis methods – Research assessment – Systematic reviews – Mathematical and statistical techniques – Statistical methods – Metaanalysis – Physical sciences – Mathematics – Statistics


Zdroje

1. You D, New J, Wardlaw T. Levels and trends in child mortality. Report 2015. Estimates developed by the UN Inter-agency Group for Child Mortality Estimation. 2015.

2. Dickson KE, Simen-Kapeu A, Kinney MV, Huicho L, Vesel L, Lackritz E, et al. Every Newborn: health-systems bottlenecks and strategies to accelerate scale-up in countries. The Lancet. 2014;384(9941):438–54.

3. UN. United Nations Millennium Declaration resolution 55/2. Fifty-fifth United Nations General Assembly, New York, 18 September 2000. 2000.

4. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. The Lancet. 2015;385(9966):430–40.

5. Unicef. Committing to child survival: a promise renewed. Progress report 2015. New York: UNICEF; 2015. 2015.

6. Lawn JE, Blencowe H, Oza S, You D, Lee AC, Waiswa P, et al. Every Newborn: progress, priorities, and potential beyond survival. The Lancet. 2014;384(9938):189–205.

7. UN. The Sustainable Development Goals Report 2016. United Nations New York, 2016. 2016.

8. WHO. Every Newborn: An action plan to end preventable deaths. 2014.

9. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010;375(9730):1969–87. doi: 10.1016/S0140-6736(10)60549-1 20466419

10. UNICEF. Levels & trends in child mortality. Estimates developed by the UN inter-agency group for child mortality estimation. New York: UNICEF. 2017.

11. Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151–61. doi: 10.1016/S0140-6736(12)60560-1 22579125

12. Lawn J, Kerber K. Opportunities for Africas newborns: practical data policy and programmatic support for newborn care in Africa. 2006.

13. Darmstadt GL, Walker N, Lawn JE, Bhutta ZA, Haws RA, Cousens S. Saving newborn lives in Asia and Africa: cost and impact of phased scale-up of interventions within the continuum of care. Health policy and planning. 2008;23(2):101–17. doi: 10.1093/heapol/czn001 18267961

14. UN DoEaSA, Population Division, Population Division. World population prospects: The 2015 Revision, Key Findings and Advance Tables. Working Paper No. ESA/P/WP. 241; 2015

15. Unicef. Committing to child survival: a promise renewed. Progress report 2015. New York: UNICEF. 2015.

16. Raven JH, Tolhurst RJ, Tang S, Van Den Broek N. What is quality in maternal and neonatal health care? Midwifery. 2012;28(5):e676–e83. doi: 10.1016/j.midw.2011.09.003 22018395

17. Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? The Lancet. 2014;384(9940):347–70.

18. World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. Geneva, Switzerland2016.

19. Adam T, Lim SS, Mehta S, Bhutta ZA, Fogstad H, Mathai M, et al. Cost effectiveness analysis of strategies for maternal and neonatal health in developing countries. Bmj. 2005;331(7525):1107. doi: 10.1136/bmj.331.7525.1107 16282407

20. Darmstadt GL, Bhutta ZA, Cousens S, Adam T, Walker N, de Bernis L, et al. Evidence-based, cost-effective interventions: how many newborn babies can we save? The Lancet. 2005;365(9463):977–88.

21. Hollowell J, Oakley L, Kurinczuk JJ, Brocklehurst P, Gray R. The effectiveness of antenatal care programmes to reduce infant mortality and preterm birth in socially disadvantaged and vulnerable women in high-income countries: a systematic review. BMC pregnancy and childbirth. 2011;11(1):1.

22. Carroli G, Villar J, Piaggio G, Khan-Neelofur D, Gülmezoglu M, Mugford M, et al. WHO systematic review of randomised controlled trials of routine antenatal care. The Lancet. 2001;357(9268):1565–70.

23. Mbuagbaw L, Medley N, Darzi AJ, Richardson M, Habiba Garga K, Ongolo‐Zogo P. Health system and community level interventions for improving antenatal care coverage and health outcomes. The Cochrane Library. 2015.

24. Ibrahim J, Yorifuji T, Tsuda T, Kashima S, Doi H. Frequency of antenatal care visits and neonatal mortality in Indonesia. J Trop Pediatr. 2012;58(3):184–8. doi: 10.1093/tropej/fmr067 21908545

25. Singh A, Pallikadavath S, Ram F, Alagarajan M. Do antenatal care interventions improve neonatal survival in India? Health policy and planning. 2013:czt066.

26. Shah D, Shroff S, Ganla K. Factors affecting perinatal mortality in India. International Journal of Gynecology and Obstetrics. 2000;71(3):209–10. doi: 10.1016/s0020-7292(00)00215-0 11102603

27. Coimbra L, Figueiredo F, Silva A, Barbieri M, Bettiol H, Caldas A, et al. Inadequate utilization of prenatal care in two Brazilian birth cohorts. Brazilian Journal of Medical and Biological Research. 2007;40(9):1195–202. doi: 10.1590/s0100-879x2006005000116 17713666

28. WHO. Women and health: today’s evidence tomorrow’s agenda. 2009.

29. UNICEF. Global databases, 2016, based on Multiple Indicator Cluster Surveys (MICS), Demographic and Health Surveys (DHS) and other nationally representative sources. 2016.

30. Doku DT, Neupane S. Survival analysis of the association between antenatal care attendance and neonatal mortality in 57 low- and middle-income countries. Int J Epidemiol. 2017;46(5):1668–77. doi: 10.1093/ije/dyx125 29040531

31. Debelew GT, Afework MF, Yalew AW. Determinants and causes of neonatal mortality in Jimma Zone, Southwest Ethiopia: a multilevel analysis of prospective follow up study. PLoS One. 2014;9(9):e107184. doi: 10.1371/journal.pone.0107184 25232842

32. Diallo AH, Meda N, Ouedraogo WT, Cousens S, Tylleskar T. A prospective study on neonatal mortality and its predictors in a rural area in Burkina Faso: can MDG-4 be met by 2015? J Perinatol. 2011;31(10):656–63. doi: 10.1038/jp.2011.6 21372798

33. Engmann C, Matendo R, Kinoshita R, Ditekemena J, Moore J, Goldenberg RL, et al. Stillbirth and early neonatal mortality in rural Central Africa. Int J Gynaecol Obstet. 2009;105(2):112–7. doi: 10.1016/j.ijgo.2008.12.012 19201402

34. Engmann C, Walega P, Aborigo RA, Adongo P, Moyer CA, Lavasani L, et al. Stillbirths and early neonatal mortality in rural Northern Ghana. Tropical Medicine & International Health. 2012;17(3):272–82.

35. Ezeh OK, Agho KE, Dibley MJ, Hall J, Page AN. Determinants of neonatal mortality in Nigeria: evidence from the 2008 demographic and health survey. BMC Public Health. 2014;14(1):1.

36. WHO, UNICEF. Trends in maternal mortality: 1990 to 2013: estimates by WHO, UNICEF, UNFPA, The World Bank and the United Nations Population Division: executive summary 2015.

37. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic reviews. 2015;4(1):1.

38. WHO. World Health Organisation: Neonatal and perinatal mortality: country, regional and global estimates. WHO. 20 Avenue Appia, 1211 Geneva 27, Switzerland; 2006.

39. Kim SY, Park JE, Lee YJ, Seo H-J, Sheen S-S, Hahn S, et al. Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity. Journal of clinical epidemiology. 2013;66(4):408–14. doi: 10.1016/j.jclinepi.2012.09.016 23337781

40. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled clinical trials. 1986;7(3):177–88. 3802833

41. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj. 2003;327(7414):557–60. doi: 10.1136/bmj.327.7414.557 12958120

42. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994:1088–101. 7786990

43. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629–34. doi: 10.1136/bmj.315.7109.629 9310563

44. Arunda M, Emmelin A, Asamoah BO. Effectiveness of antenatal care services in reducing neonatal mortality in Kenya: analysis of national survey data. Glob Health Action. 2017;10(1):1328796.

45. Kolola T, Ekubay M, Tesfa E, Morka W. Determinants of Neonatal Mortality in North Shoa Zone, Amhara Regional State, Ethiopia. PLoS One. 2016;11(10):e0164472. doi: 10.1371/journal.pone.0164472 27741284

46. Welaga P, Moyer CA, Aborigo R, Adongo P, Williams J, Hodgson A, et al. Why are babies dying in the first month after birth? A 7-year study of neonatal mortality in northern Ghana. PLoS One. 2013;8(3):e58924. doi: 10.1371/journal.pone.0058924 23527050

47. Elmi Farah A, Abbas AH, Tahir Ahmed A. Trends of admission and predictors of neonatal mortality: A hospital based retrospective cohort study in Somali region of Ethiopia. PLoS One. 2018;13(9):e0203314. doi: 10.1371/journal.pone.0203314 30216343

48. Nankabirwa V, Tumwine JK, Tylleskar T, Nankunda J, Sommerfelt H. Perinatal mortality in eastern Uganda: a community based prospective cohort study. PLoS One. 2011;6(5):e19674. doi: 10.1371/journal.pone.0019674 21573019

49. Orsido TT, Asseffa NA, Berheto TM. Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study. BMC Pregnancy Childbirth. 2019;19(1):83. doi: 10.1186/s12884-019-2227-5 30819143

50. Kidus F, Woldemichael K, Hiko D. Predictors of neonatal mortality in Assosa zone, Western Ethiopia: a matched case control study. BMC Pregnancy Childbirth. 2019;19(1):108. doi: 10.1186/s12884-019-2243-5 30925903

51. Tura G, Fantahun M, Worku A. The effect of health facility delivery on neonatal mortality: systematic review and meta-analysis. BMC Pregnancy and Childbirth. 2013;13(18).

52. Chinkhumba J, De Allegri M, Muula AS, Robberstad B. Maternal and perinatal mortality by place of delivery in sub-Saharan Africa: a meta-analysis of population-based cohort studies. BMC Public Health. 2014;14:1014. doi: 10.1186/1471-2458-14-1014 25263746

53. Titaley CR, Dibley MJ. Antenatal iron/folic acid supplements, but not postnatal care, prevents neonatal deaths in Indonesia: analysis of Indonesia Demographic and Health Surveys 2002/2003-2007 (a retrospective cohort study). BMJ Open. 2012;2(6).

54. Makate M, Makate C. The impact of prenatal care quality on neonatal, infant and child mortality in Zimbabwe: evidence from the demographic and health surveys Health policy and planning. 2017;32(3):395–404. doi: 10.1093/heapol/czw154 27993962

55. UNICEF. Committing to Child Survival: A Promise Renewed Progress Report 2014. New York: UNICEF. 2014.

56. Roper M, Vandelaer J, Gasse F. Maternal and neonatal tetanus. Lancet. 2007;370:1947–59. doi: 10.1016/S0140-6736(07)61261-6 17854885

57. Buekens P, Tsui A, Kotelchuck M, Degraft-Johnson J. Tetanus immunization and prenatal care in developing countries. Int J Gynecol Obstet 1995;48:91–4.

58. Campbell OM, Graham WJ, group LMSSs. Strategies for reducing maternal mortality: getting on with what works. The lancet. 2006;368(9543):1284–99.

59. McCurdy RJ, Kjerulff KH, Zhu J. Prenatal care associated with reduction of neonatal mortality in Sub-Saharan Africa: evidence from Demographic and Health Surveys. Acta Obstet Gynecol Scand. 2011;90(7):779–90. doi: 10.1111/j.1600-0412.2011.01133.x 21426311

60. Lawn J, Kerber K, Enweronu-Laryea C, Cousens S. 3.6 million neonatal deaths: What is progressing and what is not?. Semin Perinatology. 2010;34:371–86.

61. Diallo AH, Meda N, Zabsonre E, Sommerfelt H, Cousens S, Tylleskar T. Perinatal mortality in rural Burkina Faso: a prospective community-based cohort study. BMC Pregnancy Childbirth. 2010;10:45. doi: 10.1186/1471-2393-10-45 20716352

62. Oduro AR, Wak G, Azongo D, Debpuur C, Wontuo P, Kondayire F, et al. Profile of the Navrongo Health and Demographic Surveillance System. Int J Epidemiol. 2012;41(4):968–76. doi: 10.1093/ije/dys111 22933645

63. National Population Commission (NPC) [Nigeria] and ICF Macro. Nigeria Demographic and Health Survey 2008. Calverton, Maryland, USA: ORC Macro. 2009; Abuja, Nigeria: National Population Commission and ICF Macro.

64. Central Statistical Agency (CSA) [Ethiopia] and ICF International. Ethiopia Demographic and Health Survey 2016: Key Indicators Report: Addis Ababa, Ethiopia, and Rockville, Maryland, USA. CSA and ICF.; 2016.


Článek vyšel v časopise

PLOS One


2019 Číslo 9
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#