The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience


Autoři: Sophia D. Lin aff001;  Jane E. Butler aff001;  Claire L. Boswell-Ruys aff001;  Phu Hoang aff001;  Tom Jarvis aff003;  Simon C. Gandevia aff001;  Euan J. McCaughey aff001
Působiště autorů: Neuroscience Research Australia, Randwick, NSW, Australia aff001;  School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia aff002;  Continence Clinic, MS Limited, Sydney, Australia aff003;  Australian Catholic University, Sydney, Australia aff004;  Prince of Wales Clinical School, University of New South Wales Medicine, University of New South Wales, Sydney, NSW, Australia aff005
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222731

Souhrn

Background

Bowel and bladder problems affect more than 50% of people with Multiple Sclerosis (MS). These problems have a large impact on quality of life and place a significant burden on health systems.

Objectives

This study aimed to ascertain the frequency of bladder and bowel problems in a select Australian MS cohort and to investigate the relationships between level of disability, bladder and bowel problems, and fatigue.

Methods

Questionnaires on the nature and severity of MS symptoms were distributed to clients attending an Australian MS centre. Log-binomial regression and multiple linear regression models were used to investigate relationships between disability, fatigue, and bladder and bowel problems.

Results and conclusions

Of 167 questionnaires distributed, 136 were completed. Bladder problems were reported by 87 (74.4%) respondents, whilst 66 (48.9%) experienced functional constipation and 43 (31.9%) faecal incontinence. This frequency in our select Australian MS population is similar to that reported globally. There was a significant correlation between level of disability and: bladder problems (p = 0.015), faecal incontinence (p = 0.001), fatigue (p<0.001) and constipation (p = 0.016, relative risk: 1.16). Further investigation into the causal relationships between various MS symptoms may be beneficial in the development of novel therapeutic strategies for people with MS.

Klíčová slova:

Biology and life sciences – Anatomy – Renal system – Bladder – Medicine and health sciences – Clinical medicine – Clinical immunology – Autoimmune diseases – Multiple sclerosis – Immunology – Neurology – Demyelinating disorders – Neurodegenerative diseases – Diagnostic medicine – Signs and symptoms – Fatigue – Constipation – Pathology and laboratory medicine – Urology – Incontinence – Gastroenterology and hepatology – People and places – Geographical locations – Oceania – Australia – Computer and information sciences – Graph theory – Directed graphs – Directed acyclic graphs – Physical sciences – Mathematics – Statistics – Linear regression analysis – Research and analysis methods – Mathematical and statistical techniques – Statistical methods – Regression analysis


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PLOS One


2019 Číslo 9

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