Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis


Autoři: Alexandra Csenkey aff001;  Gergo Jozsa aff001;  Noemi Gede aff003;  Eszter Pakai aff001;  Benedek Tinusz aff003;  Zoltan Rumbus aff001;  Anita Lukacs aff004;  Zoltan Gyongyi aff005;  Peter Hamar aff003;  Robert Sepp aff006;  Andrej A. Romanovsky aff007;  Peter Hegyi aff003;  Peter Vajda aff002;  Andras Garami aff001
Působiště autorů: Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary aff001;  Department of Paediatrics, Surgical Division, University of Pecs, Pecs, Hungary aff002;  Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary aff003;  Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary aff004;  Department of Public Health Medicine, Medical School, University of Pecs, Pecs, Hungary aff005;  Second Department of Internal Medicine and Cardiology Centre, University Szeged, Szeged, Hungary aff006;  Thermoregulation and Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America aff007
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223063

Souhrn

In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious complications is debated. The present meta-analysis aimed at determining whether systemic antibiotic prophylaxis prevents infectious complications in pediatric patients with burn injuries. We searched the PubMed, EMBASE, and Cochrane Library databases from inception to August 2019. We included 6 studies, in which event rates of infectious complications were reported in children with burn injuries receiving or not receiving systemic antibiotic prophylaxis. We found that the overall odds ratio (OR) of developing an infection (including local and systemic) was not different between the groups (OR = 1.35; 95% CI, 0.44, 4.18). The chances for systemic infectious complications alone were also not different between antibiotic-treated and non-treated patients (OR = 0.74; 95% CI, 0.38, 1.45). Based on the age, affected total body surface area, and country income level, we did not find any subgroup that benefited from the prophylaxis. Our findings provide quantitative evidence for the inefficacy of systemic antibiotic prophylaxis in preventing infections in pediatric burns. To validate our conclusion, multinational, randomized trials in a diverse population of children with burn injuries are warranted.

Klíčová slova:

Antibiotics – Database searching – Metaanalysis – Pediatric infections – Pediatrics – Randomized controlled trials – Antibiotic prophylaxis – Burns


Zdroje

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Článek vyšel v časopise

PLOS One


2019 Číslo 9

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