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Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database


Autoři: Claire Faltermeier aff001;  Timothy Chai aff002;  Sharjeel Syed aff002;  Nathan Lau aff003;  Lior Elkaim aff004;  George Ibrahim aff005;  Anthony Wang aff006;  Alexander Weil aff004;  Anne Bendel aff007;  Aria Fallah aff006;  Albert Tu aff008
Působiště autorů: Department of Neurosurgery, University of California, San Francisco, CA, United States of America aff001;  Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America aff002;  Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America aff003;  Division of Neurosurgery, CHU Sainte-Justine Hospital, Université de Montréal, QC, Canada aff004;  Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto, ON, Canada aff005;  Department of Neurosurgery, Mattel Children’s Hospital, University of California, Los Angeles, CA, United States of America aff006;  Department of Hematology-Oncology, Children’s Minnesota, Minneapolis, MN, United States of America aff007;  Division of Neurosurgery, Children’s Hospital of Eastern Ontario, ON, Canada aff008
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223051

Souhrn

Introduction

Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study used a population-based approach with analysis of contemporary and historical survival curves to provide up-to-date prognostication.

Methods

Observational cohort analysis was performed using the Surveillance, Epidemiology and End Results (SEER) database. Infants with brain tumors diagnosed from 1973 to 2013 were categorized by the most common tumor types (diffuse astrocytic and oligodendroglioma, choroid plexus, embryonal, ependymal, medulloblastoma and pilocytic astrocytoma). The 1, 5 and 10 year survival was stratified by decade, with trends in management and outcomes analyzed.

Results

We identified 2996 affected infants satisfying inclusion criteria. All tumor types, except embryonal and choroid plexus, demonstrated improving survival with time. Infants with embryonal tumors showed a decline in survival from the 1970s to 1990s (p = 0.009), whereas infants with choroid plexus tumors had no change in survival. Infants with ependymal tumors experienced the greatest improvement in survival from 1980s to 1990s and 1990s to 2000s (p = 0.0001, p = 0.01), with 5-year survival probability improving from 28% (95% CI 15–42%) in the 1980s to 77% (95% CI 69–83%) the 2000s. The use of radiation declined from 1970 to 2000 for all tumors; however, radiation treatment for embryonal and ependymal subtypes increased after 2000.

Conclusions

While overall survival for infants with brain tumors has improved from the 1970s onwards, not every tumor type has seen a statistically significant change. Given changes in management and survival, prognostication of infants with brain tumor should be updated.

Klíčová slova:

Cancer treatment – Infants – Medulloblastoma – Radiation therapy – Surgical and invasive medical procedures – Surgical oncology – Choroid plexus – Astrocytoma


Zdroje

1. Birch JM, Blair V. The epidemiology of infant cancers. The British journal of cancer Supplement. 1992;18:S2–4. Epub 1992/08/01. 1503921; PubMed Central PMCID: PMC2149659.

2. Asai A, Hoffman HJ, Hendrick EB, Humphreys RP, Becker LE. Primary intracranial neoplasms in the first year of life. Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery. 1989;5(4):230–3. Epub 1989/08/01. 2790835.

3. Lafay-Cousin L, Strother D. Current treatment approaches for infants with malignant central nervous system tumors. The oncologist. 2009;14(4):433–44. Epub 2009/04/04. doi: 10.1634/theoncologist.2008-0193 19342475.

4. Galassi E, Godano U, Cavallo M, Donati R, Nasi MT. Intracranial tumors during the 1st year of life. Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery. 1989;5(5):288–98. Epub 1989/10/01. 2804999.

5. Ghodsi SM, Habibi Z, Hanaei S, Moradi E, Nejat F. Brain tumors in infants. Journal of pediatric neurosciences. 2015;10(4):335–40. Epub 2016/03/11. doi: 10.4103/1817-1745.174454 26962338; PubMed Central PMCID: PMC4770644.

6. Takaku A, Kodama N, Ohara H, Hori S. Brain tumor in newborn babies. Child's brain. 1978;4(6):365–75. Epub 1978/01/01. 308000.

7. Larouche V, Huang A, Bartels U, Bouffet E. Tumors of the central nervous system in the first year of life. Pediatric blood & cancer. 2007;49(7 Suppl):1074–82. Epub 2007/10/19. doi: 10.1002/pbc.21351 17943961.

8. Bognar L. Brain tumors during the first year of life. Annals of the New York Academy of Sciences. 1997;824:148–55. Epub 1997/11/05. doi: 10.1111/j.1749-6632.1997.tb46217.x 9382439.

9. Sakamoto K, Kobayashi N, Ohtsubo H, Tanaka Y. Intracranial tumors in the first year of life. Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery. 1986;2(3):126–9. Epub 1986/01/01. 3779667.

10. Jooma R, Hayward RD, Grant DN. Intracranial neoplasms during the first year of life: analysis of one hundred consecutive cases. Neurosurgery. 1984;14(1):31–41. doi: 10.1227/00006123-198401000-00008 6694791

11. Raimondi AJ, Tomita T. Brain tumors during the first year of life. Child's brain. 1983;10(3):193–207. Epub 1983/01/01. 6603338.

12. Bishop AJ, McDonald MW, Chang AL, Esiashvili N. Infant brain tumors: incidence, survival, and the role of radiation based on Surveillance, Epidemiology, and End Results (SEER) Data. International journal of radiation oncology, biology, physics. 2012;82(1):341–7. Epub 2010/11/03. doi: 10.1016/j.ijrobp.2010.08.020 21035954.

13. SEER Registries https://seer.cancer.gov/registries/index.html: National Cancer Institute Surveillance, Epidemiology, and End Results Program; 2018 [cited 2018].

14. Weil AG, Wang AC, Westwick HJ, Ibrahim GM, Ariani RT, Crevier L, et al. Survival in pediatric medulloblastoma: a population-based observational study to improve prognostication. Journal of neuro-oncology. 2017;132(1):99–107. Epub 2016/12/17. doi: 10.1007/s11060-016-2341-4 27981412.

15. Hochberg YBaY. Controlling the false discovery rate: a practical and powerful approach. Journal of the the Royal Statistical Society Series B (Methodological). 1995;57(1):289–300.

16. Aickin M, Gensler H. Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods. American journal of public health. 1996;86(5):726–8. Epub 1996/05/01. doi: 10.2105/ajph.86.5.726 8629727; PubMed Central PMCID: PMC1380484.

17. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta neuropathologica. 2016;131(6):803–20. Epub 2016/05/10. doi: 10.1007/s00401-016-1545-1 27157931.

18. Woehrer A, Slavc I, Waldhoer T, Heinzl H, Zielonke N, Czech T, et al. Incidence of atypical teratoid/rhabdoid tumors in children: a population-based study by the Austrian Brain Tumor Registry, 1996–2006. Cancer. 2010;116(24):5725–32. Epub 2010/08/26. doi: 10.1002/cncr.25540 20737418.

19. Johnston DL, Keene DL, Lafay-Cousin L, Steinbok P, Sung L, Carret AS, et al. Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report. Journal of neuro-oncology. 2008;86(1):101–8. Epub 2007/07/11. doi: 10.1007/s11060-007-9440-1 17619825.

20. Rorke LB, Packer RJ, Biegel JA. Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. Journal of neurosurgery. 1996;85(1):56–65. Epub 1996/07/01. doi: 10.3171/jns.1996.85.1.0056 8683283.

21. Timmermann B, Kortmann RD, Kuhl J, Rutkowski S, Meisner C, Pietsch T, et al. Role of radiotherapy in supratentorial primitive neuroectodermal tumor in young children: results of the German HIT-SKK87 and HIT-SKK92 trials. J Clin Oncol. 2006;24(10):1554–60. Epub 2006/04/01. doi: 10.1200/JCO.2005.04.8074 16575007.

22. Tekautz TM, Fuller CE, Blaney S, Fouladi M, Broniscer A, Merchant TE, et al. Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy. J Clin Oncol. 2005;23(7):1491–9. Epub 2005/03/01. doi: 10.1200/JCO.2005.05.187 15735125.

23. Chen YW, Wong TT, Ho DM, Huang PI, Chang KP, Shiau CY, et al. Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). International journal of radiation oncology, biology, physics. 2006;64(4):1038–43. Epub 2006/01/13. doi: 10.1016/j.ijrobp.2005.10.001 16406394.

24. Donahue B. Short- and long-term complications of radiation therapy for pediatric brain tumors. Pediatric neurosurgery. 1992;18(4):207–17. Epub 1992/01/01. doi: 10.1159/000120664 1472434.

25. Merchant TE, Li C, Xiong X, Kun LE, Boop FA, Sanford RA. Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study. Lancet Oncol. 2009;10(3):258–66. Epub 2009/03/11. doi: 10.1016/S1470-2045(08)70342-5 19274783; PubMed Central PMCID: PMC3615425.

26. Marinoff AE, Ma C, Guo D, Snuderl M, Wright KD, Manley PE, et al. Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival. Journal of neuro-oncology. 2017;135(1):201–11. Epub 2017/07/25. doi: 10.1007/s11060-017-2568-8 28733870; PubMed Central PMCID: PMC5658456.

27. Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, et al. Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer Cell. 2015;27(5):728–43. Epub 2015/05/13. doi: 10.1016/j.ccell.2015.04.002 25965575; PubMed Central PMCID: PMC4712639.

28. Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993;328(24):1725–31. Epub 1993/06/17. doi: 10.1056/NEJM199306173282401 8388548.

29. Kiltie AE, Lashford LS, Gattamaneni HR. Survival and late effects in medulloblastoma patients treated with craniospinal irradiation under three years old. Medical and pediatric oncology. 1997;28(5):348–54. Epub 1997/05/01. doi: 10.1002/(sici)1096-911x(199705)28:5<348::aid-mpo4>3.0.co;2-h 9121399.

30. Palmer SL, Goloubeva O, Reddick WE, Glass JO, Gajjar A, Kun L, et al. Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. J Clin Oncol. 2001;19(8):2302–8. Epub 2001/04/17. doi: 10.1200/JCO.2001.19.8.2302 11304784.

31. Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005;352(10):978–86. Epub 2005/03/11. doi: 10.1056/NEJMoa042176 15758008.

32. DeSouza RM, Jones BR, Lowis SP, Kurian KM. Pediatric medulloblastoma—update on molecular classification driving targeted therapies. Frontiers in oncology. 2014;4:176. Epub 2014/08/08. doi: 10.3389/fonc.2014.00176 25101241; PubMed Central PMCID: PMC4105823.

33. Ramaswamy V, Taylor MD. Medulloblastoma: From Myth to Molecular. J Clin Oncol. 2017;35(21):2355–63. Epub 2017/06/24. doi: 10.1200/JCO.2017.72.7842 28640708.

34. Lafay-Cousin L, Smith A, Chi SN, Wells E, Madden J, Margol A, et al. Clinical, Pathological, and Molecular Characterization of Infant Medulloblastomas Treated with Sequential High-Dose Chemotherapy. Pediatric blood & cancer. 2016;63(9):1527–34. Epub 2016/05/05. doi: 10.1002/pbc.26042 27145464; PubMed Central PMCID: PMC5031363.

35. Wallner KE, Gonzales MF, Edwards MS, Wara WM, Sheline GE. Treatment results of juvenile pilocytic astrocytoma. Journal of neurosurgery. 1988;69(2):171–6. Epub 1988/08/01. doi: 10.3171/jns.1988.69.2.0171 3392563.

36. Kehler U, Arnold H, Muller H. Long-term follow-up of infratentorial pilocytic astrocytomas. Neurosurgical review. 1990;13(4):315–20. Epub 1990/01/01. 2280843.

37. Ater JL, Zhou T, Holmes E, Mazewski CM, Booth TN, Freyer DR, et al. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. J Clin Oncol. 2012;30(21):2641–7. Epub 2012/06/06. doi: 10.1200/JCO.2011.36.6054 22665535; PubMed Central PMCID: PMC3413276.

38. Duffner PK, Krischer JP, Burger PC, Cohen ME, Backstrom JW, Horowitz ME, et al. Treatment of infants with malignant gliomas: the Pediatric Oncology Group experience. Journal of neuro-oncology. 1996;28(2–3):245–56. Epub 1996/05/01. doi: 10.1007/bf00250203 8832466.

39. Geyer JR, Finlay JL, Boyett JM, Wisoff J, Yates A, Mao L, et al. Survival of infants with malignant astrocytomas. A Report from the Childrens Cancer Group. Cancer. 1995;75(4):1045–50. Epub 1995/02/15. doi: 10.1002/1097-0142(19950215)75:4<1045::aid-cncr2820750422>3.0.co;2-k 7842407.

40. Fangusaro J, Warren KE. Unclear standard of care for pediatric high grade glioma patients. Journal of neuro-oncology. 2013;113(2):341–2. Epub 2013/03/09. doi: 10.1007/s11060-013-1104-8 23471572.

41. Dudley RW, Torok MR, Gallegos D, Liu AK, Handler MH, Hankinson TC. Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. Journal of neuro-oncology. 2015;121(1):201–7. Epub 2014/10/10. doi: 10.1007/s11060-014-1628-6 25297498.

42. Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS, et al. Treatment of choroid plexus tumors: a 20-year single institutional experience. Journal of neurosurgery Pediatrics. 2012;10(5):398–405. Epub 2012/09/04. doi: 10.3171/2012.8.PEDS12132 22938081; PubMed Central PMCID: PMC4859224.

43. Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E. Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery. 1998;42(3):470–5. Epub 1998/04/04. doi: 10.1097/00006123-199803000-00006 9526979.

44. Packer RJ, Perilongo G, Johnson D, Sutton LN, Vezina G, Zimmerman RA, et al. Choroid plexus carcinoma of childhood. Cancer. 1992;69(2):580–5. Epub 1992/01/15. doi: 10.1002/1097-0142(19920115)69:2<580::aid-cncr2820690250>3.0.co;2-o 1728390.

45. St Clair SK, Humphreys RP, Pillay PK, Hoffman HJ, Blaser SI, Becker LE. Current management of choroid plexus carcinoma in children. Pediatric neurosurgery. 1991;17(5):225–33. Epub 1991/01/01. doi: 10.1159/000120602 1822687.


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