Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database

Autoři: Claire Faltermeier aff001;  Timothy Chai aff002;  Sharjeel Syed aff002;  Nathan Lau aff003;  Lior Elkaim aff004;  George Ibrahim aff005;  Anthony Wang aff006;  Alexander Weil aff004;  Anne Bendel aff007;  Aria Fallah aff006;  Albert Tu aff008
Působiště autorů: Department of Neurosurgery, University of California, San Francisco, CA, United States of America aff001;  Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America aff002;  Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America aff003;  Division of Neurosurgery, CHU Sainte-Justine Hospital, Université de Montréal, QC, Canada aff004;  Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto, ON, Canada aff005;  Department of Neurosurgery, Mattel Children’s Hospital, University of California, Los Angeles, CA, United States of America aff006;  Department of Hematology-Oncology, Children’s Minnesota, Minneapolis, MN, United States of America aff007;  Division of Neurosurgery, Children’s Hospital of Eastern Ontario, ON, Canada aff008
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223051



Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers of reported cases. This study used a population-based approach with analysis of contemporary and historical survival curves to provide up-to-date prognostication.


Observational cohort analysis was performed using the Surveillance, Epidemiology and End Results (SEER) database. Infants with brain tumors diagnosed from 1973 to 2013 were categorized by the most common tumor types (diffuse astrocytic and oligodendroglioma, choroid plexus, embryonal, ependymal, medulloblastoma and pilocytic astrocytoma). The 1, 5 and 10 year survival was stratified by decade, with trends in management and outcomes analyzed.


We identified 2996 affected infants satisfying inclusion criteria. All tumor types, except embryonal and choroid plexus, demonstrated improving survival with time. Infants with embryonal tumors showed a decline in survival from the 1970s to 1990s (p = 0.009), whereas infants with choroid plexus tumors had no change in survival. Infants with ependymal tumors experienced the greatest improvement in survival from 1980s to 1990s and 1990s to 2000s (p = 0.0001, p = 0.01), with 5-year survival probability improving from 28% (95% CI 15–42%) in the 1980s to 77% (95% CI 69–83%) the 2000s. The use of radiation declined from 1970 to 2000 for all tumors; however, radiation treatment for embryonal and ependymal subtypes increased after 2000.


While overall survival for infants with brain tumors has improved from the 1970s onwards, not every tumor type has seen a statistically significant change. Given changes in management and survival, prognostication of infants with brain tumor should be updated.

Klíčová slova:

Cancer treatment – Infants – Medulloblastoma – Radiation therapy – Surgical and invasive medical procedures – Surgical oncology – Choroid plexus – Astrocytoma


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