Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis


Autoři: Jianzhen Shi aff001;  Xiaohui Wu aff002;  Yanmei Chen aff003
Působiště autorů: School of Science Nantong University, NanTong, P.R. China aff001;  Affiliated Hospital of Nantong University, NanTong, P.R. China aff002;  School of Environmental and Chemical Engineering Jiangsu University of Science and Technology, Zhenjiang, P.R. China aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222288

Souhrn

Objective

Systematic Review was used to evaluate the efficacy and safety of Dalfampridine (DAP) in the treatment of Mobility Disability (MS) in patients with Multiple Sclerosis.

Methods

Clinical randomized controlled studies about DAP and placebo in the treatment of Mobility Disability in patients with Multiple Sclerosis until March 2019 were explored by searching Embase, PubMed, Cochrane, Web of Knowledge, and ClinicalTrials.gov. Literature screening, data extraction, quality assessment, and statistical analysis were performed by using Stata 14.0.

Results

10 papers were included in the meta-analysis, and the number of patients was 2100. In conclusion, the application of DAP in clinical can significantly improve the Mobility Disability of patients [OR = 2.73, 95%CI (1.66, 4.50), P<0.001, I2 = 74.1%] and boost the mobility speed of patients in Timing 24 Minute Walk Test (T24FW) [SMD = 3,08, 95%CI(1,58, 4.58), P<0.001, I2 = 98.7%]. There are no significant differences of the incidence of adverse events [RR = 1.06, 95%CI (0.99, 1.14), P = 0.928, I2 = 0.0%] and urinary tract infection [RR = 1.21, 95%CI(0.91, 1.60), P = 0.145, I2 = 37.2%] between the DAP test group (Doses≤10 mg) and the placebo control group, and the incidence of adverse events [RR = 1.14, 95%CI(1.02, 1.28), P = 0.793, I2 = 0.0%] and urinary tract infection[RR = 3.05, 95%CI(1.04, 8.99), P = 0.680, I2 = 0.0%] for the DAP test group (Doses>10 mg) is a litter higher than the placebo control group.

Conclusion

DAP can effectively improve Mobility Disability in patients with Multiple Sclerosis, which is safe and reliable in specific DAP usage doses.

Klíčová slova:

Research and analysis methods – Mathematical and statistical techniques – Statistical methods – Metaanalysis – Research design – Clinical research design – Adverse events – Physical sciences – Mathematics – Statistics – Physics – Biophysics – Medicine and health sciences – Clinical medicine – Clinical immunology – Autoimmune diseases – Multiple sclerosis – Immunology – Neurology – Demyelinating disorders – Neurodegenerative diseases – Public and occupational health – Disabilities – Urology – Urinary tract infections – Biology and life sciences – Physiology – Electrophysiology – Neurophysiology – Neuroscience – Biochemistry – Proteins – Anatomy – Renal system – Science policy – Research integrity – Publication ethics


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Článek vyšel v časopise

PLOS One


2019 Číslo 9

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