Serum E-selectin concentration is associated with risk of metabolic syndrome in females


Autoři: Chien-Hsing Lee aff001;  Feng-Chih Kuo aff001;  Wen-Hao Tang aff002;  Chieh-Hua Lu aff001;  Sheng-Chiang Su aff001;  Jhih-Syuan Liu aff001;  Chang-Hsun Hsieh aff001;  Yi-Jen Hung aff002;  Fu-Huang Lin aff003
Působiště autorů: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC aff001;  Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Song Shan Branch, Taipei, Taiwan, ROC aff002;  School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222815

Souhrn

Objectives

Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated.

Methods

A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20–75 years and BMI < 35 kg/m2. Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender.

Results

Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125).

Conclusions

Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.

Klíčová slova:

Biomarkers – Blood plasma – Diabetes mellitus – Hypertension – Cholesterol – Inflammation – Metabolic syndrome – Obesity


Zdroje

1. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, et al. Adiponectin as a biomarker of the metabolic syndrome. Circulation Journal. 2004; 68(11):975–81. doi: 10.1253/circj.68.975 15502375

2. Gündogan K, Bayram F, Capak M, Tanriverdi F, Karaman A, Ozturk A, et al. Prevalence of metabolic syndrome in the Mediterranean region of Turkey: evaluation of hypertension, diabetes mellitus, obesity, and dyslipidemia. Metabolic Syndrome and Related Disorders. 2009; 7(5):427–34. doi: 10.1089/met.2008.0068 19754305

3. Iqbal Hydrie MZ, Shera AS, Fawwad A, Basit A, Hussain D Sc A. Prevalence of metabolic syndrome in urban Pakistan (Karachi): comparison of newly proposed International Diabetes Federation and modified Adult Treatment Panel III criteria. Metabolic Syndrome and Related Disorders. 2009; 7(2):119–24. doi: 10.1089/met.2008.0055 18928398

4. Pan W-H, Yeh W-T, Weng L-C. Epidemiology of metabolic syndrome in Asia. Asia Pacific Journal of Clinical Nutrition. 2008; 17(S1):37–42.

5. Misra A, Khurana L. The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metabolic Syndrome and Related Disorders. 2009; 7(6):497–514. doi: 10.1089/met.2009.0024 19900153

6. Hwang L-C, Bai C-H, Chen C-J. Prevalence of obesity and metabolic syndrome in Taiwan. Journal of the Formosan Medical Association. 2006; 105(8):626–35. doi: 10.1016/S0929-6646(09)60161-3 16935763

7. Tsou M-T. Metabolic syndrome in metabolic obese, non-obese elderly in northern Taiwan. Advances in Aging Research. 2012; 1(03):53.

8. Er L-K, Chen Y-L, Pei D, Lau SC, Kuo S-W, Hsu C-H. Increased incidence of metabolic syndrome in older men with high normotension. The Aging Male. 2012; 15(4):227–32. doi: 10.3109/13685538.2012.720742 23035946

9. Mabry R, Reeves M, Eakin E, Owen N. Gender differences in prevalence of the metabolic syndrome in Gulf Cooperation Council Countries: a systematic review. Diabetic Medicine. 2010; 27(5):593–7. doi: 10.1111/j.1464-5491.2010.02998.x 20536958

10. Bener A, Mohammad A-G, Ismail AN, Zirie M, Abdullatef WK, Al-Hamaq AO. Gender and agerelated differences in patients with the metabolic syndrome in a highly endogamous population. Bosnian journal of basic medical sciences. 2010; 10(3):210. doi: 10.17305/bjbms.2010.2687 20846127

11. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annual Review of Immunology. 2011; 29:415–45. doi: 10.1146/annurev-immunol-031210-101322 21219177

12. Eder K, Baffy N, Falus A, Fulop AK. The major inflammatory mediator interleukin-6 and obesity. Inflammation Research. 2009; 58(11):727. doi: 10.1007/s00011-009-0060-4 19543691

13. Kowalska I, Szelachowska M, Kinalska I, Prokop J, Bach H, St A. Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism. Metabolism-Clinical. 2002; 51(6):733–6.

14. Carter A, Grant P. Vascular homeostasis, adhesion molecules, and macrovascular disease in non-insulin-dependent diabetes mellitus. Diabetic Medicine. 1997; 14(6):423–32. doi: 10.1002/(SICI)1096-9136(199706)14:6<423::AID-DIA421>3.0.CO;2-F 9212306

15. Zanni MV, Stanley TL, Makimura H, Chen CY, Grinspoon SK. Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic dysregulation. Clinical Endocrinology. 2010; 73(1):48–54. doi: 10.1111/j.1365-2265.2009.03741.x 19878508

16. Hung Y-J, Lee C-H, Chu N-F, Shieh Y-S. Plasma Protein Growth Arrest–Specific 6 Levels Are Associated With Altered Glucose Tolerance, Inflammation, and Endothelial Dysfunction. Diabetes Care. 2010; 33(8):1840–4. doi: 10.2337/dc09-1073 20504897

17. Tan C-E, Ma S, Wai D, Chew S-K, Tai E-S. Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? Diabetes Care. 2004; 27(5):1182–6. doi: 10.2337/diacare.27.5.1182 15111542

18. Matsumoto K, Sera Y, Nakamura H, Ueki Y, Miyake S. Serum concentrations of soluble adhesion molecules are related to degree of hyperglycemia and insulin resistance in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice. 2002; 55(2):131–8. doi: 10.1016/s0168-8227(01)00296-0 11796179

19. Matsumoto K, Sera Y, Abe Y, Tominaga T, Horikami K, Hirao K, et al. High serum concentrations of soluble E-selectin correlate with obesity but not fat distribution in patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental. 2002; 51(7):932–4.

20. Boulbou M, Koukoulis G, Vasiou K, Petinaki E. Increased soluble E-selectin levels in type 2 diabetic patients with peripheral arterial disease. International Angiology. 2004; 23(1):18. 15156125

21. Hwang S-J, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto AM Jr, et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation Journal. 1997; 96(12):4219–25.

22. Rubin D, Claas S, Pfeuffer M, Nothnagel M, Foelsch UR, Schrezenmeir J. s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal. Lipids in Health and Disease. 2008; 7(1):32.

23. Palomo IG, Jaramillo JC, Alarcón ML, Gutiérrez CL, Moore-Carrasco R, Segovia FM, et al. Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome. Molecular Medicine Reports. 2009; 2(3):481–5. doi: 10.3892/mmr_00000125 21475854

24. Abramov Y, Schenker J, Levin A. Kafka|,| afle H, Barak V. The role of plasma adhesive molecules (ELAM+ ICAM) and biological aspects of ovarian hyperstimulation syndrome (OHSS). Fertility and Sterility. 2001:7651–7.

25. Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Modern Pathology. 2010; 23(8):1136. doi: 10.1038/modpathol.2010.98 20495539

26. DANIEL Y, GEVA E, BAR‐AM A, LESSING JB, AMIT A, GEVA E, et al. Soluble endothelial and platelet selectins in serum and ascitic fluid of women with ovarian hyperstimulation syndrome. American Journal of Reproductive Immunology and Microbiology. 2001; 45(3):154–60.

27. Viganò P, Fusi F, Gaffuri B, Bonzi V, Ferrari A, Vignali M. Soluble intercellular adhesion molecule-1 in ovarian follicles: production by granulosa luteal cells and levels in follicular fluid. Fertility and Sterility. 1998; 69(4):774–9. doi: 10.1016/s0015-0282(97)00565-7 9548172

28. Yasui T, Saijo A, Uemura H, Matsuzaki T, Tsuchiya N, Yuzurihara M, et al. Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy. European Journal of Endocrinology of the European Federation of Endocrine Societies. 2009; 161(2):267–73.

29. Elhadd T, Neary R, Abdu T, Kennedy G. Influence of the hormonal changes during the normal menstrual cycle in healthy young women on soluble adhesion molecules, plasma homocysteine, free radical markers and lipoprotein fractions. International Angiology. 2003; 22(3):222. 14612848

30. Piercy KT, Donnell RL, Kirkpatrick SS, Timaran CH, Stevens SL, Freeman MB, et al. Effects of estrogen, progesterone, and combination exposure on interleukin-1β-induced expression of VCAM-1, ICAM-1, PECAM, and E-selectin by human female iliac artery endothelial cells. Journal of Surgical Research. 2002; 105(2):215–9. doi: 10.1006/jsre.2002.6405 12121710

31. Cominacini L, Pasini AF, Garbin U, Davoli A, De Santis A, Campagnola M, et al. Elevated levels of soluble E-selectin in patients with IDDM and NIDDM: relation to metabolic control. Diabetologia Croatica. 1995; 38(9):1122–4.

32. Abe Y, El-Masri B, Kimball KT, Pownall H, Reilly CF, Osmundsen K, et al. Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion. Arteriosclerosis, Thrombosis, and Vascular Biology. 1998; 18(5):723–31. doi: 10.1161/01.atv.18.5.723 9598830

33. Calabresi L, Gomaraschi M, Villa B, Omoboni L, Dmitrieff C, Franceschini G. Elevated soluble cellular adhesion molecules in subjects with low HDL-cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology. 2002; 22(4):656–61. doi: 10.1161/hq0402.105901 11950706

34. Cockerill GW, Saklatvala J, Ridley SH, Yarwood H, Miller NE, Oral B, et al. High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2. Arteriosclerosis, Thrombosis, and Vascular Biology. 1999; 19(4):910–7. doi: 10.1161/01.atv.19.4.910 10195917

35. De Caterina R, Ghiadoni L, Taddei S, Virdis A, Almerigogna F, Basta G, et al. Soluble E-selectin in essential hypertension: a correlate of vascular structural changes. American Journal of Hypertension. 2001; 14(3):259–66. doi: 10.1016/s0895-7061(00)01276-0 11281238

36. Roldán V, Marín F, Lip GY, Blann AD. Soluble E-selectin in cardiovascular disease and its risk factors. Thrombosis and Haemostasis. 2003; 90(12):1007–20.

37. Wang Z, Xu Y, Chen S, Wang L, Ding H, Lu G, et al. A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population. Hypertension Research. 2012; 35(4):413. doi: 10.1038/hr.2011.204 22158116

38. Jager A, van Hinsbergh VW, Kostense PJ, Emeis JJ, Nijpels G, Dekker JM, et al. Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study. Diabetes and Metabolic Syndrome. 2000; 49(3):485–91.

39. Kawamura T, Umemura T, Kanai A, Uno T, Matsumae H, Sano T, et al. The incidence and characteristics of silent cerebral infarction in elderly diabetic patients: association with serum-soluble adhesion molecules. Diabetologia Croatica. 1998; 41(8):911–7.

40. Turhan H, Saydam GS, Erbay AR, Ayaz S, Yasar AS, Aksoy Y, et al. Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. International Journal of Cardiology. 2006; 108(2):224–30. doi: 10.1016/j.ijcard.2005.05.008 16002164

41. Cominacini L, Pasini AF, Garbin U, Campagnola M, Davoli A, Rigoni A, et al. E-selectin plasma concentration is influenced by glycaemic control in NIDDM patients: possible role of oxidative stress. Diabetologia Croatica. 1997; 40(5):584–9.

42. Ceriello A, Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, et al. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes and Metabolic Syndrome. 2004; 53(3):701–10.

43. Trøseid M, Lappegård K, Mollnes T, Arnesen H, Seljeflot I. Changes in serum levels of E-selectin correlate to improved glycaemic control and reduced obesity in subjects with the metabolic syndrome. Scandinavian Journal of Clinical and Laboratory Investigation. 2005; 65(4):283–90. doi: 10.1080/00365510510013811 16076683

44. Weiss TW, Arnesen H, Seljeflot I. Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness. Metabolism: Clinical and Experimental. 2013; 62(7):1008–13.


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