Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study


Autoři: Hsin-Hua Chen aff001;  Ching-Heng Lin aff002;  Der-Yuan Chen aff007;  Wen-Cheng Chao aff002;  Yi-Hsing Chen aff003;  Wei-Ting Hung aff010;  Yin-Yi Chou aff010;  Yi-Da Wu aff010;  Chien-Chih Chen aff001
Působiště autorů: Ph.D. Program in Translational Medicine, National Chung-Hsing University, Taichung, Taiwan, Republic of China aff001;  Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aff002;  School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China aff003;  Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan, Republic of China aff004;  Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan, Republic of China aff005;  Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan, Republic of China aff006;  Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan, Republic of China aff007;  Translational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan, Republic of China aff008;  School of Medicine, China Medical University, Taichung, Taiwan, Republic of China aff009;  Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aff010;  Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aff011
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222860

Souhrn

Background

Breast cancer is one of the most common malignancies among women. However, there remains no consensus in current literature on the incidence of autoimmune diseases among breast cancer patients. The purpose of this study was to evaluate the risks of major autoimmune diseases (MAD) including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS) and dermatomyositis (DMtis)/polymyositis (PM) in female breast cancer patients.

Methods

Using the Taiwanese National Health Insurance Research Database (NHIRD) records from 2003 to 2013, we identified newly-diagnosed female breast cancer patients and randomly selected females without breast cancer in the period 2007 to 2013 into a control group. We matched the two cohorts using a 1:4 ratio based on age, and the year of index date for comparison of the risk of major autoimmune diseases. We estimated and compared the relative risks of autoimmune diseases in female breast cancer patients and females without breast cancer.

Results

A total of 54,311 females with breast cancer and 217,244 matched females without breast cancer were included in this study. For SLE, the incidence rates were 2.3 (breast cancer group) vs. 10.0 (control group) per 100,000 women years; for RA rates were 19.3 (breast cancer group) vs. 42.7 (control group) per 100,000 women years; and for SS rates were 20.5 (breast cancer group) vs. 38.2 (control group) per 100,000 women years. After adjusting for potential confounders, the hazard ratios (95% confidence intervals) for female breast cancer patients vs. control group were 0.04 (0.01–0.24) for SLE; 0.03 (0.02–0.04) for RA; and 0.21 (0.09–0.48) for SS.

Conclusion

Female breast cancer patients had lower risks of SLE, RA and SS when compared to female individuals without breast cancer. However, there was no significant difference in the risk of developing DMtis/PM between both groups.

Klíčová slova:

Medicine and health sciences – Oncology – Cancers and neoplasms – Breast tumors – Breast cancer – Cancer treatment – Cancer chemotherapy – Clinical oncology – Clinical medicine – Clinical immunology – Autoimmune diseases – Lupus erythematosus – Systemic lupus erythematosus – Immunology – Rheumatology – Arthritis – Rheumatoid arthritis – Pharmaceutics – Drug therapy – Hormonal therapy – Chemotherapy – Diagnostic medicine – Cancer detection and diagnosis – Biology and life sciences


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