Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry


Autoři: Sungsu Youk aff001;  Dong-Hun Lee aff002;  Helena L. Ferreira aff001;  Claudio L. Afonso aff001;  Angel E. Absalon aff004;  David E. Swayne aff001;  David L. Suarez aff001;  Mary J. Pantin-Jackwood aff001
Působiště autorů: Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, Athens, Georgia, United States of America aff001;  Department of Pathobiology & Veterinary Science, University of Connecticut, Storrs, Mansfield, Connecticut, United States of America aff002;  University of Sao Paulo, ZMV- FZEA, Pirassununga, Brazil aff003;  Instituto Politécnico Nacional, Centro de Investigación en Biotecnología Aplicada, Tlaxcala, México aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222457

Souhrn

Highly pathogenic avian influenza (HPAI) virus subtype H7N3 has been circulating in poultry in Mexico since 2012 and vaccination has been used to control the disease. In this study, eight Mexican H7N3 HPAI viruses from 2015–2017 were isolated and fully sequenced. No evidence of reassortment was detected with other avian influenza (AI) viruses, but phylogenetic analyses show divergence of all eight gene segments into three genetic clusters by 2015, with 94.94 to 98.78 percent nucleotide homology of the HA genes when compared to the index virus from 2012. The HA protein of viruses from each cluster showed a different number of basic amino acids (n = 5–7) in the cleavage site, and six different patterns at the predicted N-glycosylation sites. Comparison of the sequences of the Mexican lineage H7N3 HPAI viruses and American ancestral wild bird AI viruses to characterize the virus evolutionary dynamics showed that the nucleotide substitution rates in PB2, PB1, PA, HA, NP, and NS genes greatly increased once the virus was introduced into poultry. The global nonsynonymous and synonymous ratios imply strong purifying selection driving the evolution of the virus. Forty-nine positively selected sites out of 171 nonsynonymous mutations were identified in the Mexican H7N3 HPAI viruses, including 7 amino acid changes observed in higher proportion in North American poultry origin AI viruses isolates than in wild bird-origin viruses. Continuous monitoring and molecular characterization of the H7N3 HPAI virus is important for better understanding of the virus evolutionary dynamics and further improving control measures including vaccination.

Klíčová slova:

People and places – Population groupings – Ethnicities – Latin American people – Mexican people – Biology and life sciences – Organisms – Eukaryota – Animals – Vertebrates – Amniotes – Birds – Poultry – Evolutionary biology – Evolutionary systematics – Phylogenetics – Phylogenetic analysis – Evolutionary processes – Evolutionary rate – Organismal evolution – Microbial evolution – Viral evolution – Taxonomy – Genetics – Animal genetics – Bird genetics – Microbiology – Virology – Biochemistry – Glycobiology – Glycosylation – Proteins – Post-translational modification – Computer and information sciences – Data management – Research and analysis methods – Database and informatics methods – Bioinformatics – Sequence analysis


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