Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland


Autoři: Jakub Dworzański aff001;  Bartłomiej Drop aff002;  Ewa Kliszczewska aff003;  Małgorzata Strycharz-Dudziak aff004;  Małgorzata Polz-Dacewicz aff003
Působiště autorů: Masovian Specialist Hospital, Radom, Poland aff001;  Department of Information Technology and Medical Statistics, Medical University of Lublin, Lublin, Poland aff002;  Department of Virology, Medical University of Lublin, Lublin, Poland aff003;  Chair and Department of Conservative Dentistry with Endodontics, Medical University of Lublin, Lublin, Poland aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222607

Souhrn

A microbiota is a complex ecosystem of microorganisms consisting of bacteria, viruses, protozoa, and fungi living in different niches of the human body, which plays an essential role in many metabolic functions. Modifications in the microbiota composition can lead to several diseases, including metabolic disorders. The aim of this study was to analyze the prevalence of four viruses which can cause persistent infections–Epstein-Barr virus (EBV), human papillomavirus (HPV), cytomegalovirus (CMV), and herpes simplex virus type 1 (HSV-1) in patients with diabetes mellitus type 2 (DM2). Blood, saliva and oral swabs were collected from all the study participants. The nested-PCR technique was used to detect the viral DNA. DNA of at least one virus was detected in 71.1% of diabetic patients and in 30% of individuals without diabetes. In patients with diabetes EBV DNA was detected the most frequently (25.4%), followed by HPV– 19.1%, HSV– 10.4% and CMV– 5.2%. A higher percentage of EBV+HPV co-infection was found among men (30.8%). EBV DNA was statistically more often detected in patients living in rural areas (53.7%), while HPV (91.5%) and EBV+HPV co-infection (22.2%) prevailed among patients from urban areas. In patients with a DM2 history longer than 10 years viral infection was detected more frequently. The prevalence of EBV, HPV and the EBV+HPV co-infection was significantly higher in diabetic patients than in individuals without diabetes. The frequency of these infections depended on the duration of the disease (DM2).

Klíčová slova:

Co-infections – Cytomegalovirus infection – Diabetes mellitus – Epstein-Barr virus – Human papillomavirus infection – Microbiome – Herpes simplex virus – Viral persistence and latency


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PLOS One


2019 Číslo 9

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