Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality

Autoři: Julián Benito-León aff001;  Israel Contador aff004;  Saturio Vega aff005;  Alberto Villarejo-Galende aff001;  Félix Bermejo-Pareja aff003
Působiště autorů: Department of Neurology, University Hospital “12 de Octubre”, Madrid, Spain aff001;  Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain aff002;  Department of Medicine, Complutense University, Madrid, Spain aff003;  Department of Basic Psychology, Psychobiology and Methodology of Behavioural Sciences, University of Salamanca, Salamanca, Spain aff004;  Arévalo Health Center, Arévalo, Ávila, Spain aff005;  Clinical Research Unit (I+12), University Hospital “12 de Octubre”, Madrid, Spain aff006
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222505


Alzheimer disease (AD) mortality risk in a large cohort of subjects treated or not with non-steroidal anti-inflammatory drugs (NSAIDs) is unknown. Our objective was to determine whether NSAIDs use is associated with decreased risk of AD mortality. In this prospective, population-based study (Neurological Disorders in Central Spain [NEDICES]) of 5,072 people without AD (aged 65 years and older), sociodemographic, comorbidity factors, and current medications were recorded at baseline. Community-dwelling older adults were followed for a median of 12.7 years, after which the death certificates of deceased participants were examined. 2,672 (52.7%) of 5,072 participants died, including 504 (18.9%) NSAIDs users and 2,168 (81.1%) non-users. Of the 2,672 deceased participants, 113 (4.2%) had AD as a cause of death (8 [1.6%] among NSAIDs users and 105 [4.8%] among non-users, chi-square = 10.70, p = 0.001). In an unadjusted Cox model, risk of AD mortality was decreased in NSAIDs users (hazard ratio [HR] for AD mortality = 0.35, 95% confidence interval [CI] 0.17–0.72, p = 0.004) when compared to non-users. After adjusting for numerous demographic factors and co-morbidities, the HR for AD mortality in NSAIDs users was 0.29, 95% CI 0.12–0.73, p = 0.009. Stratified analyses showed a significantly decreased risk of AD mortality with aspirin, whereas non-aspirin NSAIDs only showed a statistical trend toward significance in the adjusted Cox regression models. NSAIDs use was associated with 71% decreased risk of AD mortality in older adults. Our results support the hypothesis that NSAIDs use is a protective factor of developing AD.

Klíčová slova:

Medicine and health sciences – Pharmacology – Drugs – Analgesics – NSAIDs – Pain management – Mental health and psychiatry – Dementia – Alzheimer's disease – Neurology – Neurodegenerative diseases – Cognitive neurology – Cerebrovascular diseases – Vascular medicine – Blood pressure – Hypertension – Primary hypertension – Secondary hypertension – Biology and life sciences – Neuroscience – Cognitive science – Cognitive neuroscience – Social sciences – Sociology – Education – Educational attainment


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