Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization
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Hiromi Kurokawa aff001; Hiromu Ito aff002; Masahiko Terasaki aff003; Daisuke Matano aff003; Atsushi Taninaka aff004; Hidemi Shigekawa aff004; Hirofumi Matsui aff001
Působiště autorů:
Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
aff001; Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
aff002; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
aff003; Faculty of Pure and Applied Sciences, University of Tsukuba, Ibaraki, Japan
aff004
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222074
Souhrn
Photodynamic therapy (PDT) is a cancer therapy that capitalizes on cancer-specific porphyrin accumulation. We have investigated this phenomenon to propose the following three conclusions: 1) the mechanism underlying this phenomenon is closely related to both nitric oxide (NO) and heme carrier protein-1 (HCP-1), 2) NO inactivates ferrochelatase, and thus, the intracellular porphyrin levels in the cells are increased by the administration of an NO donor after 5-aminolevulinic acid treatment, 3) HCP-1 transports not only heme but also other porphyrins. Since NO stabilizes hypoxia-inducible factor (HIF)-1α, resulting in the upregulation of heme biosynthesis, HCP-1 expression can be increased by HIF-1α stabilization. In this study, we determined whether NO regulates HCP-1 expression by stabilizing HIF-1α expression. For this purpose, rat gastric cancer cell line RGK36 was treated with L-arginine or N6-(1-iminoethyl)-L-lysine (L-NIL). L-arginine treatment increased the intracellular NO concentration, and both HCP-1 and HIF-1α expression, while L-NIL treatment decreased them. Cytotoxicity of PDT was enhanced by L-arginine, following intracellular hemato-porphyrin dihydrochloride (HpD) accumulation. Both Cytotoxicity of PDT and HpD accumulation were decreased by L-NIL. The HCP-1 and HIF-1α expression, intracellular HpD accumulation and PDT cytotoxicity were decreased by 2-methoxyestradiol, which is a HIF-1α inhibitor. Moreover, these phenomena were not increased by a combination of both L-arginine and 2-Me. Thus, HCP-1 can be a downstream target of HIF-1α. These effects were also induced in the human gastric cancer cell line MKN45. Taken together, we conclude that HCP-1 expression is regulated by NO via HIF-1α stabilization.
Klíčová slova:
Biology and life sciences – Biochemistry – Neurochemistry – Neurochemicals – Nitric oxide – Proteins – Post-translational modification – Heme – Neuroscience – Toxicology – Cytotoxicity – Physical sciences – Chemistry – Chemical compounds – Organic compounds – Porphyrins – Organic chemistry – Medicine and health sciences – Pathology and laboratory medicine – Oncology – Cancer treatment – Cancers and neoplasms – Gastrointestinal tumors – Gastric cancer – Engineering and technology – Equipment – Optical equipment – Lasers – Research and analysis methods – Electrophoretic techniques – Gel electrophoresis
Zdroje
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