Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study

Autoři: Helmut Ellemunter aff001;  Gratiana Steinkamp aff001
Působiště autorů: Cystic Fibrosis (CF) Centre at the Medical University of Innsbruck, Innsbruck, Austria aff001;  Clinical Research and Medical Scientific Writing, Schwerin, Germany aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0221673


Comparing the efficacy of inhaled antibiotics can be difficult in small groups of patients with cystic fibrosis and mild lung disease. In a feasibility study we compared Aztreonam lysine for inhalation solution (AZLI; Cayston®) to standard inhaled antibiotic therapy in patients with cystic fibrosis and near normal spirometry. To detect treatment responses we used both lung clearance index (LCI) and forced expiratory volume in one second (FEV1). At baseline, median FEV1 was 87% pred. and median LCI was 8.6 (upper limit of normal: 7.0). After 4 weeks, LCI improved by -0.36 after AZLI and deteriorated by +0.12 after tobramycin treatment (p = 0.039). No significant differences between treatments (p = 0.195) were observed using FEV1. These results suggest that lung clearance index can be used to detect treatment induced changes in subjects with mild lung disease.

Klíčová slova:

Medicine and health sciences – Pharmacology – Drugs – Clinical genetics – Genetic diseases – Autosomal recessive diseases – Cystic fibrosis – Pulmonology – Respiratory infections – Respiration – Inhalation – Respiratory physiology – Pathology and laboratory medicine – Pathogens – Biology and life sciences – Microbiology – Microbial control – Antimicrobials – Antibiotics – Medical microbiology – Microbial pathogens – Bacterial pathogens – Pseudomonas aeruginosa – Developmental biology – Fibrosis – Physiology – Physiological processes – Organisms – Bacteria – Pseudomonas – Biochemistry – Proteins – Amino acids – Basic amino acids – Lysine – Research and analysis methods – Bioassays and physiological analysis – Respiratory analysis – Spirometry – Physical sciences – Chemistry – Chemical compounds – Organic compounds – Organic chemistry


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2019 Číslo 9