Incidence of retinal vein occlusion with long-term exposure to ambient air pollution

Autoři: Han-Wei Zhang aff001;  Chao-Wen Lin aff004;  Victor C. Kok aff005;  Chun-Hung Tseng aff007;  Yuan-Pei Lin aff002;  Tsai-Chung Li aff008;  Fung-Chang Sung aff010;  Chi Pang Wen aff003;  Chao A. Hsiung aff003;  Chung Y. Hsu aff011
Působiště autorů: PhD Program for Aging, China Medical University, Taichung, Taiwan aff001;  Institute of Electrical Control Engineering, Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan aff002;  Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aff003;  Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan aff004;  Disease Informatics Research Group, Asia University Taiwan, Taichung, Taiwan aff005;  Department of Internal Medicine, Kuang Tien General Hospital, Taichung, Taiwan aff006;  Department of Neurology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan aff007;  Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan aff008;  Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan aff009;  Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan aff010;  Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan aff011
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222895


This study aimed to investigate whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among the population of Taiwan. A retrospective cohort study involving 855,297 people was conducted. Cox proportional hazards regression analysis fitted the multiple pollutant models for two targeted pollutants, including total hydrocarbons (THC), nonmethane hydrocarbons (NMHC) were used, and the risk of RVO was estimated. The chi-squared test and one-way analysis of variance were used to test differences in demographics and comorbidity distribution among tertiles of the targeted pollutants. Before controlling for multiple pollutants, hazard ratios for the overall population were 19.88 (95% CI: 17.56–22.50) at 0.51-ppm increases in THC and 4.33 (95% CI: 3.97–4.73) at 0.27-ppm increases in NMHC. The highest adjusted hazard ratios for different multiple pollutant models of each targeted pollutant were statistically significant (all p values were ≤0.05) for all patients at 29.67 (95% CI: 25.57–34.42) for THC and 16.24 (95% CI: 14.14–18.65) for NMHC. Our findings suggest that long-term exposure to THC and NMHC contribute to RVO development.

Klíčová slova:

Air pollution – Cerebrovascular diseases – Hydrocarbons – Medical risk factors – Particulates – Taiwan – Pollutants – Retinal vessels


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