Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016


Autoři: Claire von Mollendorf aff001;  Sophie La Vincente aff001;  Mukhchuluun Ulziibayar aff003;  Bujinlkham Suuri aff003;  Dashtseren Luvsantseren aff003;  Dorj Narangerel aff004;  John de Campo aff001;  Margaret de Campo aff001;  Cattram Nguyen aff001;  Sodbayar Demberelsuren aff006;  Tuya Mungun aff003;  E. Kim Mulholland aff001
Působiště autorů: New Vaccines, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Vic., Australia aff001;  Department of Paediatrics, The University of Melbourne, Parkville, Australia aff002;  National Center of Communicable Diseases (NCCD), Ministry of Health, Ulaanbaatar, Mongolia aff003;  Ministry of Health, Ulaanbaatar, Mongolia aff004;  Department of Radiology, The University of Melbourne, Parkville, Australia aff005;  Expanded Programme on Immunization, World Health Organization, Ulaanbaatar, Mongolia aff006;  Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, England, United Kingdom aff007
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222423

Souhrn

Background

Respiratory diseases, including pneumonia, are the second largest cause of under-five mortality in Mongolia and the most common cause of childhood hospitalization. However information regarding the contribution of Streptococcus pneumoniae to pneumonia causation in Mongolia is limited. We aimed to describe the epidemiology of hospitalized children aged 2–59 months with pneumonia, enrolled into a surveillance program in the period prior to pneumococcal conjugate vaccine (PCV) introduction, in Mongolia.

Methods

An expanded pneumonia surveillance program enrolled children, who met the surveillance case definition, at participating hospitals, between April 2015 and May 2016. Cumulative incidence rates were calculated by district for all pneumonia endpoints using district specific denominators from the Mongolian Health Department census for 2016. Socio-economic and disease-associated factors were compared between districts using chi-squared tests.

Results

A total of 4318 eligible children with pneumonia were enrolled over the 14 month period. Overall the incidence for all-cause pneumonia in children aged 12–59 months was 31.8 per 1000 population; children aged 2–11 months had an almost four-fold higher incidence than children aged 12–59 months.

Differences were found between districts with regards to housing type, fuel used for cooking, hospital admission practices and the proportions of severe and primary endpoint pneumonia.

Discussion

This study shows a high burden of pneumonia in children aged 2–59 months in Mongolia prior to PCV introduction. Rates differed somewhat by district and age group and were influenced by a number of socio-economic factors. It will be important to consider these differences and risk factors when assessing the impact of PCV introduction.

Klíčová slova:

Medicine and health sciences – Pulmonology – Pneumonia – Epidemiology – Medical risk factors – Infectious diseases – Infectious disease control – Vaccines – Conjugate vaccines – Health care – Health care facilities – Hospitals – People and places – Geographical locations – Asia – Mongolia – Population groupings – Age groups – Physical sciences – Chemistry – Chemical elements – Oxygen – Earth sciences – Geography – Human geography – Housing – Social sciences – Human geography – Housing


Zdroje

1. Sonego M, Pellegrin MC, Becker G, Lazzerini M. Risk factors for mortality from acute lower respiratory infections (ALRI) in children under five years of age in low and middle-income countries: a systematic review and meta-analysis of observational studies. PLoS One. 2015;10(1):e0116380. doi: 10.1371/journal.pone.0116380 25635911; PubMed Central PMCID: PMC4312071.

2. Walker CL, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. Lancet. 2013;381(9875):1405–16. doi: 10.1016/S0140-6736(13)60222-6 23582727.

3. Centre for Health Development. Health Indicators 2016. Ulaanbaater 2016.

4. Jadambaa A, Spickett J, Badrakh B, Norman RE. The impact of the environment on health in Mongolia: a systematic review. Asia Pac J Public Health. 2015;27(1):45–75. doi: 10.1177/1010539514545648 25113526.

5. O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, McCall N, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet. 2009;374(9693):893–902. doi: 10.1016/S0140-6736(09)61204-6 19748398.

6. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008;86(5):408–16. doi: 10.2471/BLT.07.048769 18545744; PubMed Central PMCID: PMC2647437.

7. La Vincente SF, von Mollendorf C, Ulziibayar M, Satzke C, Dashtseren L, Fox KK, et al. Evaluation of a phased pneumococcal conjugate vaccine introduction in Mongolia using enhanced pneumonia surveillance and community carriage surveys: a study protocol for a prospective observational study and lessons learned. BMC Public Health. 2019;19(1):333. Epub 2019/03/23. doi: 10.1186/s12889-019-6639-y 30898094; PubMed Central PMCID: PMC6429832.

8. World Health Organization. Invasive Bacterial Vaccine Preventable Diseases Laboratory Network 2018 Available from: http://www.who.int/immunization/monitoring_surveillance/burden/laboratory/IBVPD/en/ (Accessed 27 November 2018).

9. Satzke C, Turner P, Virolainen-Julkunen A, Adrian PV, Antonio M, Hare KM, et al. Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group. Vaccine. 2013;32(1):165–79. Epub 2013/12/18. doi: 10.1016/j.vaccine.2013.08.062 24331112.

10. Cherian T, Mulholland EK, Carlin JB, Ostensen H, Amin R, de Campo M, et al. Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull World Health Organ. 2005;83(5):353–9. doi: /S0042-96862005000500011 15976876; PubMed Central PMCID: PMC2626240.

11. World Health Organization. IMCI integrated management of childhood illness. 2005. Available from: https://apps.who.int/iris/bitstream/handle/10665/42939/9241546441.pdf;jsessionid=02A6FF9DE8E4AF56D94A77AE0B9DEF51?sequence=1 (Accessed 20 Feb 2019).

12. Burmaa A, Kamigaki T, Darmaa B, Nymadawa P, Oshitani H. Epidemiology and impact of influenza in Mongolia, 2007–2012. Influenza Other Respir Viruses. 2014;8(5):530–7. doi: 10.1111/irv.12268 25043147; PubMed Central PMCID: PMC4181816.

13. National Influenza Center NCCD, Ministry of Health Mongolia. ILI surveillance report 2015/2016. Available from: http://www.flu.mn/eng/index.php?option=com_content&task=category&sectionid=5&id=51&Itemid=51 (Accessed 17 Sep 2017).

14. McAllister DA, Liu L, Shi T, Chu Y, Reed C, Burrows J, et al. Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis. Lancet Glob Health. 2019;7(1):e47–e57. Epub 2018/12/01. doi: 10.1016/S2214-109X(18)30408-X 30497986; PubMed Central PMCID: PMC6293057.

15. Magree HC, Russell FM, Sa'aga R, Greenwood P, Tikoduadua L, Pryor J, et al. Chest X-ray-confirmed pneumonia in children in Fiji. Bull World Health Organ. 2005;83(6):427–33. doi: /S0042-96862005000600010 15976893; PubMed Central PMCID: PMC2626254.

16. Gessner BD, Sutanto A, Linehan M, Djelantik IG, Fletcher T, Gerudug IK, et al. Incidences of vaccine-preventable Haemophilus influenzae type b pneumonia and meningitis in Indonesian children: hamlet-randomised vaccine-probe trial. Lancet. 2005;365(9453):43–52. doi: 10.1016/s0140-6736(04)17664-2 15643700.

17. Virkki R, Juven T, Rikalainen H, Svedstrom E, Mertsola J, Ruuskanen O. Differentiation of bacterial and viral pneumonia in children. Thorax. 2002;57(5):438–41. doi: 10.1136/thorax.57.5.438 11978922; PubMed Central PMCID: PMC1746322.

18. Andrade DC, Borges IC, Vilas-Boas AL, Fontoura MSH, Araujo-Neto CA, Andrade SC, et al. Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia. J Pediatr (Rio J). 2018;94(1):23–30. Epub 2017/07/03. doi: 10.1016/j.jped.2017.03.004 28668258.

19. Nascimento-Carvalho CM, Araujo-Neto CA, Ruuskanen O. Association between bacterial infection and radiologically confirmed pneumonia among children. Pediatr Infect Dis J. 2015;34(5):490–3. Epub 2015/04/17. doi: 10.1097/INF.0000000000000622 25879649.

20. Dagvadorj A, Ota E, Shahrook S, Baljinnyam Olkhanud P, Takehara K, Hikita N, et al. Hospitalization risk factors for children's lower respiratory tract infection: A population-based, cross-sectional study in Mongolia. Sci Rep. 2016;6:24615. doi: 10.1038/srep24615 27090182; PubMed Central PMCID: PMC4835771.


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2019 Číslo 9

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